scholarly journals Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Via Oxidative Stress and Iron−Sulfur Cluster Biogenesis Deficit

2020 ◽  
Vol 33 (17) ◽  
pp. 1191-1208 ◽  
Author(s):  
Wisna Novera ◽  
Zheng-Wei Lee ◽  
Dawn Sijin Nin ◽  
Melvin Zi-Yu Dai ◽  
Shabana Binte Idres ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Ovarian Clear Cell Carcinoma ◽  
Iron Sulfur Cluster ◽  
Sulfur Cluster ◽  
Iron Sulfur

scholarly journals Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant

2016 ◽  
Vol 50 (4) ◽  
pp. 414-425 ◽  
Author(s):  
Yasushi Yamada ◽  
Tsutomu Miyamoto ◽  
Hiroyasu Kashima ◽  
Hisanori Kobara ◽  
Ryoichi Asaka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Carcinoma Cells ◽  
Lipocalin 2 ◽  
Ovarian Clear Cell Carcinoma ◽  
Cd44 Variant

Abstract PR08: HNF1β confers resistance to oxidative stress of ovarian clear cell carcinoma

2013 ◽  
Author(s):  
Yasuaki Amano ◽  
Ken Yamaguchi ◽  
Masaki Mandai ◽  
Noriomi Matsumura ◽  
Junzo Hamanishi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Ovarian Clear Cell Carcinoma

HNF1B contributes to resistance to oxidative stress through modification of metabolism in ovarian clear cell carcinoma

2014 ◽  
Vol 133 ◽  
pp. 87
Author(s):  
K. Yamaguchi ◽  
Y. Amano ◽  
N. Matsumura ◽  
M. Mandai ◽  
K. Abiko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Ovarian Clear Cell Carcinoma

Hypoxia-inducible Factor-1α Suppression in Ovarian Clear-cell Carcinoma Cells by Silibinin Administration

2020 ◽  
Vol 40 (12) ◽  
pp. 6791-6798
Author(s):  
MARIKO MIYAZAWA ◽  
MASANORI YASUDA ◽  
MASAKI MIYAZAWA ◽  
NAOKI OGANE ◽  
TOMOMI KATOH ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Hypoxia Inducible Factor ◽  
Carcinoma Cells ◽  
Ovarian Clear Cell Carcinoma ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Targeting FXYD2 by cardiac glycosides potently blocks tumor growth in ovarian clear cell carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (39) ◽  
pp. 62925-62938 ◽  
Author(s):  
I-Ling Hsu ◽  
Cheng-Yang Chou ◽  
Yi-Ying Wu ◽  
Jia-En Wu ◽  
Chen-Hsien Liang ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Cell Carcinoma ◽  
Cardiac Glycosides ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Ovarian Clear Cell Carcinoma

scholarly journals Mismatch repair deficiency is associated with specific morphologic features and frequent loss of ARID1A expression in ovarian clear cell carcinoma

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Huijuan Ge ◽  
Yaoxin Xiao ◽  
Guangqi Qin ◽  
Yanzi Gu ◽  
Xu Cai ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Tumor Infiltrating Lymphocytes ◽  
Tissue Microarrays ◽  
Ovarian Clear Cell Carcinoma ◽  
Repair Deficiency ◽  
Ovarian Epithelial Carcinoma ◽  
Histological Characteristics ◽  
Infiltrating Lymphocytes

Abstract Background Ovarian clear cell carcinoma (OCCC) is the second subtype of ovarian epithelial carcinoma reported to be closely related to Lynch syndrome (LS). ARID1A mutation is an important pathogenetic mechanism in OCCC that leads to loss of ARID1A expression in approximately half of OCCCs. However, the correlation of MMR status and ARID1A deficiency is unclear. The current study aimed to identify the clinical and histopathological characteristics of OCCC associated with dMMR and to further explore the association between dMMR and ARID1A deficiency. Methods A cohort of 176 primary OCCC patients was enrolled and review included histological characteristics (nuclear atypia, necrosis, mitosis, stromal hyalinization, and background precursors) and host inflammatory response (tumor-infiltrating lymphocytes, peritumoral lymphocytes, intratumoral stromal inflammation and plasma cell infiltration). Immunohistochemical staining of MLH1, PMS2, MSH2, MSH6 and ARID1A was performed using tissue microarrays. Results dMMR was detected in 10/176 tumors (6 %), followed by MSH2/MSH6 (6/176), MLH1/PMS2 (3/176), and MSH6 (1/176). The average age of patients with dMMR was younger than that of patients with intact MMR (46 y vs. 53 y). Tumors with diffuse intratumoral stromal inflammation remained significantly associated after multivariate analysis. ARID1A expression was absent in 8 patients with dMMR (8/10), which is a significantly higher frequency than that observed in patients with intact MMR (80 % vs. 43.2 %). Conclusions Our study indicates that diffuse intratumoral stromal inflammation of OCCCs is associated with dMMR, with loss of MSH2/MSH6 expression being most frequent. dMMR is strongly associated with the loss of ARID1A expression in OCCC.

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