scholarly journals Glutaredoxin1 Diminishes Amyloid Beta-Mediated Oxidation of F-Actin and Reverses Cognitive Deficits in an Alzheimer's Disease Mouse Model

2019 ◽  
Vol 31 (18) ◽  
pp. 1321-1338 ◽  
Author(s):  
Reddy Peera Kommaddi ◽  
Deepika Singh Tomar ◽  
Smitha Karunakaran ◽  
Deepti Bapat ◽  
Siddharth Nanguneri ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Beta ◽  
Cognitive Deficits ◽  
Mediated Oxidation

P1-033: Cognitive deficits and plaque deposition in a gene-targeted mouse model of Alzheimer's disease

2009 ◽  
Vol 5 (4S_Part_6) ◽  
pp. P181-P181
Author(s):  
John Ciallella ◽  
Heather Hain ◽  
Bryan Strenkowski ◽  
Michelle Hogga ◽  
Stacey Galvin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Cognitive Deficits ◽  
Plaque Deposition ◽  
Model Of Alzheimer’S Disease

scholarly journals Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease

Redox Biology ◽  
2017 ◽  
Vol 12 ◽  
pp. 843-853 ◽  
Author(s):  
Athanassios Fragoulis ◽  
Stephanie Siegl ◽  
Markus Fendt ◽  
Sandra Jansen ◽  
Ulf Soppa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Oral Administration ◽  
Cognitive Deficits ◽  
Model Of Alzheimer’S Disease

scholarly journals Functional and structural connectome properties in the 5XFAD transgenic mouse model of Alzheimer’s disease

2018 ◽  
Vol 2 (2) ◽  
pp. 241-258 ◽  
Author(s):  
Shelli R. Kesler ◽  
Paul Acton ◽  
Vikram Rao ◽  
William J. Ray
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mice ◽  
Transgenic Mouse ◽  
Amyloid Beta ◽  
Molecular Mechanisms ◽  
Diffusion Tensor ◽  
Transgenic Mouse Model ◽  
Structural Connectome

Neurodegeneration in Alzheimer’s disease (AD) is associated with amyloid-beta peptide accumulation into insoluble amyloid plaques. The five-familial AD (5XFAD) transgenic mouse model exhibits accelerated amyloid-beta deposition, neuronal dysfunction, and cognitive impairment. We aimed to determine whether connectome properties of these mice parallel those observed in patients with AD. We obtained diffusion tensor imaging and resting-state functional magnetic resonance imaging data for four transgenic and four nontransgenic male mice. We constructed both structural and functional connectomes and measured their topological properties by applying graph theoretical analysis. We compared connectome properties between groups using both binarized and weighted networks. Transgenic mice showed higher characteristic path length in weighted structural connectomes and functional connectomes at minimum density. Normalized clustering and modularity were lower in transgenic mice across the upper densities of the structural connectome. Transgenic mice also showed lower small-worldness index in higher structural connectome densities and in weighted structural networks. Hyper-correlation of structural and functional connectivity was observed in transgenic mice compared with nontransgenic controls. These preliminary findings suggest that 5XFAD mouse connectomes may provide useful models for investigating the molecular mechanisms of AD pathogenesis and testing the effectiveness of potential treatments.

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