Abrogation of Toll-Like Receptor 4 Mitigates Obesity-Induced Oxidative Stress, Proinflammation, and Insulin Resistance Through Metabolic Reprogramming of Mitochondria in Adipose Tissue

2020 ◽  
Vol 33 (2) ◽  
pp. 66-86 ◽  
Author(s):  
Hung-Yu Lin ◽  
Shao-Wen Weng ◽  
Feng-Chih Shen ◽  
Yen-Hsiang Chang ◽  
Wei-Shiung Lian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Adipose Tissue ◽  
Metabolic Reprogramming ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

2009 ◽  
Vol 10 (5) ◽  
pp. 419-429 ◽  
Author(s):  
Maziyar Saberi ◽  
Niels-Bjarne Woods ◽  
Carl de Luca ◽  
Simon Schenk ◽  
Juu Chin Lu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Hematopoietic Cell ◽  
Toll Like Receptor ◽  
High Fat ◽  
Toll Like Receptor 4 ◽  
Specific Deletion

scholarly journals TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation

2019 ◽  
Vol 20 (17) ◽  
pp. 4112 ◽  
Author(s):  
Amal Hasan ◽  
Nadeem Akhter ◽  
Areej Al-Roub ◽  
Reeby Thomas ◽  
Shihab Kochumon ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Human Monocytes ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Metabolic Inflammation ◽  
Tnf Α ◽  
Key Driver ◽  
Tlr4 Signaling Pathway

Elevated levels of IL-8 (CXCL8) in obesity have been linked with insulin resistance and type 2 diabetes (T2D). The mechanisms that lead to the profound production of IL-8 in obesity remains to be understood. TNF-α and saturated free fatty acids (FFAs) are increased in obese humans and correlate with insulin resistance. Hence, we sought to investigate whether the cooccurrence of TNF-α and FFAs led to increase the production of IL-8 by human monocytes. We found that co-stimulation of human monocytes with palmitate and TNF-α led to increased IL-8 production as compared to those stimulated with palmitate or TNF-α alone. The synergistic production of IL-8 by TNF-α/palmitate was suppressed by neutralizing anti- Toll like receptor 4 (TLR4) antibody and by genetic silencing of TLR4. Both MyD88-deficient and MyD88-competent cells responded comparably to TNF-α/Palmitate. However, TIR-domain-containing adapter-inducing interferon (TRIF) inhibition or interferon regulatory transcription factor 3 (IRF3) knockdown partly blocked the synergistic production of IL-8. Our human data show that increased adipose tissue TNF-α expression correlated positively with IL-8 expression (r = 0.49, P = 0.001). IL-8 and TNF-α correlated positively with macrophage markers including CD68, CD163 and CD86 in adipose tissue. These findings suggest that the signaling cross-talk between saturated fatty acid palmitate and TNF-α may be a key driver in obesity-associated chronic inflammation via an excessive production of IL-8.

scholarly journals Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging

Aging ◽  
2017 ◽  
Vol 9 (9) ◽  
pp. 1971-1982 ◽  
Author(s):  
Amiya K. Ghosh ◽  
Martin O’Brien ◽  
Theresa Mau ◽  
Raymond Yung
Keyword(s):  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Tissue Inflammation ◽  
Deficient Mice

scholarly journals Adipokines: mechanisms of metabolic and behavioral disorders

2018 ◽  
Vol 15 (3) ◽  
pp. 14-20
Author(s):  
Yassine Chahirou ◽  
Abdelhalim Mesfioui ◽  
Ali Ouichou ◽  
Aboubaker Hessni
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Behavioral Disorders ◽  
Health Problems ◽  
Endocrine Tissue ◽  
Physiological Functions ◽  
Relationship Of ◽  
The Relationship

Current studies show that metabolic and behavioral disorders represent severe health problems. Several questions arise about the molecular relationship of metabolic and behavioral disorders. This review will discuss the relationship of lipid metabolism and fructose consumption accompanied by an increase in weight as well as associated disorders: hypertension, insulin-resistance, oxidative stress and depression. Adipose tissue is considered as an endocrine tissue with intense secretory activities (metabolic and inflammatory). These adipokines are responsible for an alteration of several physiological functions. In this review we will try to understand how lipogenesis that causes dyslipidemia can influence insulin resistance, hypertension, oxidative stress, depression and the relationship between these various disorders.

scholarly journals Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 110
Author(s):  
Brisamar Estébanez ◽  
Alexandra L. Rodriguez ◽  
Nishant P. Visavadiya ◽  
Michael Whitehurst ◽  
María J. Cuevas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aerobic Training ◽  
Oxidative Stress Response ◽  
Pentraxin 3 ◽  
Elderly Adults ◽  
Nitrogen Species ◽  
Toll Like Receptor ◽  
Oxidative Stress Biomarkers ◽  
Toll Like Receptor 4 ◽  
Stress Biomarkers

Reactive oxygen and nitrogen species-mediated cellular aging has been linked to diseases such as atherothrombosis and cancer. Although pentraxin 3 (PTX3) is associated with aging-related diseases via TLR4-dependent anti-inflammatory effects, its relationship with oxidative stress in aging remains to be elucidated. Exercise is proposed as the key intervention for health maintenance in the elderly. This study aimed to examine the association of PTX3 levels with changes in oxidative stress in both plasma and peripheral blood mononuclear cells (PBMCs), following aerobic training in elderly adults. Nine trained and five controls participated in an eight-week aerobic training protocol. Enzyme-linked immunosorbent assay (ELISA) and Western blot analyses were used to determine PTX3, toll-like receptor 4 (TLR4), and levels of oxidative stress biomarkers [3-nitrotyrosine (3NT), 4-hydroxynonenal (4-HNE), glutathione (GSH), protein carbonyl (PC), reactive oxygen/ nitrogen species (ROS/RNS), and trolox equivalent antioxidant capacity (TEAC)] in plasma and/or PBMCs. Results showed a down-regulation of PTX3 expression in PBMCs following aerobic training, along with decreased PTX3/TLR4 ratios. Oxidative stress responses in PBMCs remained unchanged with the exercise protocol. Comparable levels of plasma PTX3 and oxidative stress biomarkers were observed in trained vs. control groups. No correlation was found between PTX3 and any oxidative stress biomarkers following training. These findings demonstrated the down-regulation of PTX3 and PTX3/TLR4 ratio, irrespective of oxidative stress response, in elderly adults following eight weeks of aerobic training.

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