Illumination with 630 nm Red Light Reduces Oxidative Stress and Restores Memory by Photo-Activating Catalase and Formaldehyde Dehydrogenase in SAMP8 Mice

2019 ◽  
Vol 30 (11) ◽  
pp. 1432-1449 ◽  
Author(s):  
Jingnan Zhang ◽  
Xiangpei Yue ◽  
Hongjun Luo ◽  
Wenjing Jiang ◽  
Yufei Mei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Red Light ◽  
Formaldehyde Dehydrogenase ◽  
Samp8 Mice

The Antioxidant Resveratrol from Polygonum Cuspidatum Reverses Memory Impairment and Brain Oxidative Stress in SAMP8 Mice

2011 ◽  
Vol 422 ◽  
pp. 470-473
Author(s):  
Gui Shan Liu ◽  
Ze Sheng Zhang ◽  
Bo Yang ◽  
Wei He
Keyword(s):  
Oxidative Stress ◽  
Learning And Memory ◽  
Open Field ◽  
Field Test ◽  
Memory Impairment ◽  
Open Field Test ◽  
Pharmacological Action ◽  
Age Related ◽  
Brain Oxidative Stress ◽  
Samp8 Mice

Resveratrol (RVT) is a phytoalexin polyphenolic compound found in various plants, including grapes, berries and peanuts. Recently, studies have documented various health benefits of resveratrol including cardiovascular and cancer-chemopreventive properties. The aim of the present study was to demonstrate the effects of resveratrol on the learning and memory impairment. The senescence-accelerated mice (SAM) were introgastric gavage administrated resveratrol (25,100mg/(kg•bw)) for 60 days. The learning and memory behavior was assessed using open-field test while the parameters of oxidative stress assessed were malondialdehyde (MDA) and superoxide dismutases (SOD).The results showed that resveratrol significantly improved the learning and memory ability in open-field test. Further investigation showed that resveratrol restored SOD levels, but decreased MDA level in the mouce brain. These results indicated that the pharmacological action of RVT may offer a novel therapeutic strategy for the treatment of age-related conditions.

scholarly journals Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress

2019 ◽  
Author(s):  
Alba Garcia-Just ◽  
Lluïsa Miró ◽  
Anna Pérez-Bosque ◽  
Concepció Amat ◽  
Javier Polo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Decline ◽  
Brain Tissue ◽  
Cognitive Performance ◽  
Dietary Supplementation ◽  
Low Grade ◽  
Anti Inflammatory ◽  
Samp8 Mice ◽  
And Oxidative Stress ◽  
Spray Dried

ABSTRACT Background Aging is characterized by chronic, low-grade inflammation that correlates with cognitive decline. Dietary supplementation with spray-dried porcine plasma (SDP) reduces immune activation in rodent models of inflammation and aging. Objective We investigated whether the anti-inflammatory properties of SDP could ameliorate age-related cognitive deterioration and preserve brain homeostasis in an aging mouse model of senescence. Methods Male senescence-accelerated prone 8 (SAMP8) mice were used. In Experiment 1, cognitive performance (n  = 10–14 mice/group) was analyzed by the novel object recognition test in 2-mo-old mice (2M group) and in mice fed a control diet or a diet supplemented with 8% SDP for 2 (4M-CTL and 4M-SDP groups) and 4 mo (6M-CTL and 6M-SDP groups). In Experiment 2, the permeability of the blood–brain barrier and junctional proteins in brain tissue was assessed, as well as synaptic density, oxidative stress markers, and inflammatory genes and proteins in mice from the 2M, 6M-CTL, and 6M-SDP groups ( n = 5–11). Statistical analyses included one-factor ANOVA followed by Fisher's posthoc test. Results 6M-SDP mice had better cognitive performance than 6M-CTL mice in both short-term (P = 0.024) and long-term (P = 0.017) memory tests. In brain tissue, 6M-SDP mice showed reduced brain capillary permeability (P = 0.034) and increased ZO1 and E-cadherin expression (both P <0.04) compared with 6M-CTL mice. SDP also prevented the NFκB activation observed in 6M-CTL mice (P = 0.002) and reduced Il6 expression and hydrogen peroxide concentration (both P <0.03) observed in 6M-CTL mice. SDP also increased the concentration of IL10 (P = 0.027), an anti-inflammatory cytokine correlated with memory preservation. Conclusions In senescent SAMP8 mice, dietary supplementation with SDP attenuated cognitive decline and prevented changes in brain markers of neuroinflammation and oxidative stress.

Effect of Growth Hormone Treatment on Pancreatic Inflammation, Oxidative Stress, and Apoptosis Related to Aging in SAMP8 Mice

2011 ◽  
Vol 14 (5) ◽  
pp. 501-512 ◽  
Author(s):  
Sara Cuesta ◽  
Roman Kireev ◽  
Cruz García ◽  
Katherine Forman ◽  
Elena Vara ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Samp8 Mice

Cerebrosides from Sea Cucumber Protect Against Oxidative Stress in SAMP8 Mice and PC12 Cells

2017 ◽  
Vol 20 (4) ◽  
pp. 392-402 ◽  
Author(s):  
Hongxia Che ◽  
Lei Du ◽  
Peixu Cong ◽  
Suyuan Tao ◽  
Ning Ding ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pc12 Cells ◽  
Sea Cucumber ◽  
Samp8 Mice

scholarly journals Autophagy upregulation and loss of NF-κB in oxidative stress-related immunodeficient SAMP8 mice

2009 ◽  
Vol 130 (11-12) ◽  
pp. 722-730 ◽  
Author(s):  
Beatriz Caballero ◽  
Ignacio Vega-Naredo ◽  
Verónica Sierra ◽  
David DeGonzalo-Calvo ◽  
Pablo Medrano-Campillo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Samp8 Mice

scholarly journals A Diet Rich in Olive Oil Phenolics Reduces Oxidative Stress in the Heart of SAMP8 Mice by Induction of Nrf2-Dependent Gene Expression

2012 ◽  
Vol 15 (1) ◽  
pp. 71-81 ◽  
Author(s):  
Banu Bayram ◽  
Beraat Ozcelik ◽  
Stefanie Grimm ◽  
Thomas Roeder ◽  
Charlotte Schrader ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Olive Oil ◽  
Samp8 Mice
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