scholarly journals Targeting of PP2Cδ By a Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer Progression In Vivo

2019 ◽  
Vol 30 (17) ◽  
pp. 1983-1998 ◽  
Author(s):  
Ke Wu ◽  
Xiaoting Yu ◽  
Zhimin Huang ◽  
Donghui Zhu ◽  
Xianghua Yi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Small Molecule ◽  
High Glucose ◽  
Breast Cancer Progression

scholarly journals Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo

2014 ◽  
Vol 9 (1) ◽  
pp. 282-294 ◽  
Author(s):  
Natalie Falkenberg ◽  
Nataša Anastasov ◽  
Ines Höfig ◽  
Ksenia Bashkueva ◽  
Katrin Lindner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression

LncRNA NEAT1 accelerates breast cancer progression through regulating miR-410-3p/ CCND1 axis

2020 ◽  
Vol 29 (2) ◽  
pp. 277-290
Author(s):  
Xuan Liu ◽  
Weirong Yao ◽  
Haiwei Xiong ◽  
Qiang Li ◽  
Yingliang Li
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Breast Cancer Cells ◽  
Breast Cancer Progression ◽  
Cell Counting ◽  
Luciferase Reporter ◽  
Cancer Tissues

BACKGROUND: Breast cancer is the most common malignant tumor and usually occurs in women. Studies have shown that lncRNA nuclear enriched abundant transcript 1 (NEAT1) contributes to breast cancer progression. This study intends to further investigate the molecular mechanism of NEAT1 in breast cancer. METHODS: The expression levels of NEAT1, miR-410-3p and Cyclin D1 (CCND1) were detected by quantitative real-time PCR (qRT-PCR) in breast cancer tissues and cells. Kaplan-Meier analysis and the log-rank test were performed to determine the relationship between NEAT1 and overall survival. Cell Counting Kit-8 (CCK-8) assay analyzed cell proliferation. Transwell assay was performed to examine cell migration and invasion. The protein levels of CCND1 and epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin, N-cadherin and Vimentin) were measured by western blot. The target relationship was predicted by bioinformatics analysis, and confirmed by luciferase reporter assay and RNA Immunoprecipitation (RIP) assay. Xenograft analysis was used to evaluate the tumor growth in vivo. RESULTS: NEAT1 and CCND1 were upregulated, while miR-410-3p was down-regulated in breast cancer tissues and cells. Higher NEAT1 expression level was associated with lower survival rate of breast cancer patients. Knockdown of miR-410-3p restored silenced NEAT1-mediated the inhibition of on proliferation, migration, invasion and EMT of breast cancer cells. In addition, NEAT1 regulated CCND1 expression by sponging miR-410-3p in breast cancer cells. NEAT1 knockdown blocked the tumor growth in vivo. CONCLUSION: NEAT1 induced breast cancer progression by regulating the miR-410-3p/CCND1 axis, indicating that NEAT1 may be a potential therapeutic target in breast cancer.

Salinomycin inhibits breast cancer progression via targeting HIF-1α/VEGF mediated tumor angiogenesis in vitro and in vivo

2019 ◽  
Vol 164 ◽  
pp. 326-335 ◽  
Author(s):  
Jayant Dewangan ◽  
Sonal Srivastava ◽  
Sakshi Mishra ◽  
Aman Divakar ◽  
Sadan Kumar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Tumor Angiogenesis ◽  
Breast Cancer Progression

scholarly journals Morphine Promotes Tumor Angiogenesis and Increases Breast Cancer Progression

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Sabrina Bimonte ◽  
Antonio Barbieri ◽  
Domenica Rea ◽  
Giuseppe Palma ◽  
Antonio Luciano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Mouse Model ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Cancer Cell Growth ◽  
Patients With Cancer ◽  
Human Breast Carcinoma Cells

Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Severalin vitroandin vivostudies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to better dissect the role of morphine in cancer cell growth and angiogenesis we performedin vitrostudies on ER-negative human breast carcinoma cells, MDA.MB231 andin vivostudies on heterotopic mouse model of human triple negative breast cancer, TNBC. We demonstrated that morphinein vitroenhanced the proliferation and inhibited the apoptosis of MDA.MB231 cells.In vivostudies performed on xenograft mouse model of TNBC revealed that tumours of mice treated with morphine were larger than those observed in other groups. Moreover, morphine was able to enhance the neoangiogenesis. Our data showed that morphine at clinical relevant doses promotes angiogenesis and increases breast cancer progression.

scholarly journals In vitro and in vivo effects of a nutrient mixture on breast cancer progression

2014 ◽  
Vol 44 (6) ◽  
pp. 1933-1944 ◽  
Author(s):  
M.W. ROOMI ◽  
T. KALINOVSKY ◽  
N.M. ROOMI ◽  
J. CHA ◽  
M. RATH ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
In Vivo Effects

scholarly journals In Vivo Investigation of Breast Cancer Progression by Use of an Internal Control

Neoplasia ◽  
2009 ◽  
Vol 11 (3) ◽  
pp. 220-227 ◽  
Author(s):  
John Baeten ◽  
Jodi Haller ◽  
Helen Shih ◽  
Vasilis Ntziachristos
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Internal Control ◽  
Breast Cancer Progression
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