Effects of Diesel Exhaust on Cardiovascular Function and Oxidative Stress

2018 ◽  
Vol 28 (9) ◽  
pp. 819-836 ◽  
Author(s):  
Simon J. Wilson ◽  
Mark R. Miller ◽  
David E. Newby
Keyword(s):  
Oxidative Stress ◽  
Diesel Exhaust ◽  
Cardiovascular Function ◽  
And Oxidative Stress

scholarly journals Seasonal Changes In Cardiovascular Function, Risk Factors, And Oxidative Stress Of Wildland Firefighters

2020 ◽  
Vol 52 (7S) ◽  
pp. 815-815
Author(s):  
Cassie Williamson-Reisdorph ◽  
Katie S. Christison ◽  
Shae C. Gurney ◽  
Kathryn G.S. Tiemessen ◽  
Joseph A. Sol ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Seasonal Changes ◽  
Cardiovascular Function ◽  
And Oxidative Stress

scholarly journals Diesel Exhaust Particles Synergistically Enhance Lung Injury and Oxidative Stress Induced by Bacterial Endotoxin

2006 ◽  
Vol 38 (3) ◽  
pp. 133-137 ◽  
Author(s):  
Toyoko Arimoto ◽  
Ken-ichiro Inoue ◽  
Rie Yanagisawa ◽  
Ronald P. Mason ◽  
Hirohisa Takano
Keyword(s):  
Oxidative Stress ◽  
Lung Injury ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Bacterial Endotoxin ◽  
Exhaust Particles ◽  
And Oxidative Stress

scholarly journals Short-term Diesel Exhaust Exposure Results in Neuroinflammation and White Matter Injury

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 640-640
Author(s):  
Krista Lamorie-Foote ◽  
Kristina Shkirkova ◽  
Qinghai Liu ◽  
Constantinos Sioutas ◽  
Todd Morgan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
White Matter ◽  
Corpus Callosum ◽  
Diesel Exhaust ◽  
Time Course ◽  
Ambient Air ◽  
White Matter Injury ◽  
Ambient Air Pollution ◽  
Diesel Exhaust Particulate ◽  
And Oxidative Stress

Abstract Ambient air pollution (AAP) exposure is associated with white matter injury and cognitive decline in older adults(Chen et al. 2020,Erickson et al. 2020). Neuroinflammation and oxidative stress may contribute to this white matter injury. Diesel exhaust particulate matter (DEP) is a neurotoxic component of AAP.This study characterizes the time course by which neuroinflammation/oxidative stress occurs and results in white matter injury following DE exposure in a murine model. DEP (Sigma) was re-aerosolized for exposure. Mice were exposed to 100 µg/m3 DEP or filtered air (FA) for 5 hours (n=8/group), 100 hours (n=6/group), or 200 hours (n=6/group). Immunohistochemical analysis of degraded myelin basic protein (dMBP), a marker of myelin damage, was performed. Neuroinflammation and oxidative stress were assessed by histological analysis of complement C5a, an anaphylatoxin, and 4-Hydroxynonenal (4-HNE), a marker of lipid peroxidation.dMBP integrated density was increased in the corpus callosum of DEP mice at 5 (p<0.01), 100 (p<0.01), and 200 hours (p<0.001) compared to FA mice.C5a integrated density was increased in the corpus callosum of DEP mice at 5 (p<0.01), 100 (p<0.01), and 200 hours (p<0.01) compared to FA mice. 4-HNE integrated density was increased in the corpus callosum of DEP mice at 5 (p<0.001), 100 (p=0.001), and 200 hours (p<0.001) compared to FA mice. Neuroinflammation and oxidative stress are upregulated with associated white matter injury in the corpus callosum after 5 hours of DEP exposure.Short-term DEP exposure activates inflammatory/oxidative stress pathways, which may contribute to the pathogenesis of white matter injury.Erickson et al. 2020,PMID:32182984; Chen et al. 2020,PMID:32669395.

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