Nitro-Fatty Acids: Formation, Redox Signaling, and Therapeutic Potential

2013 ◽  
Vol 19 (11) ◽  
pp. 1257-1265 ◽  
Author(s):  
Andrés Trostchansky ◽  
Lucía Bonilla ◽  
Lucía González-Perilli ◽  
Homero Rubbo
Keyword(s):  
Fatty Acids ◽  
Therapeutic Potential ◽  
Redox Signaling

scholarly journals Furanoid F-Acid F6 Uniquely Induces NETosis Compared to C16 and C18 Fatty Acids in Human Neutrophils

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 144 ◽  
Author(s):  
Meraj Khan ◽  
Cecil Pace-Asciak ◽  
Jassim Al-Hassan ◽  
Mohammad Afzal ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Therapeutic Potential ◽  
Lipid Fraction ◽  
Arabian Gulf ◽  
Dienoic Acid ◽  
Neutrophil Extracellular Trap ◽  
Gas Chromatography Mass Spectrometry ◽  
Human Neutrophils ◽  
Long Chain

Various biomolecules induce neutrophil extracellular trap (NET) formation or NETosis. However, the effect of fatty acids on NETosis has not been clearly established. In this study, we focused on the NETosis-inducing ability of several lipid molecules. We extracted the lipid molecules present in Arabian Gulf catfish (Arius bilineatus, Val) skin gel, which has multiple therapeutic activities. Gas chromatography–mass spectrometry (GC-MS) analysis of the lipid fraction-3 from the gel with NETosis-inducing activity contained fatty acids including a furanoid F-acid (F6; 12,15-epoxy-13,14-dimethyleicosa-12,14-dienoic acid) and common long-chain fatty acids such as palmitic acid (PA; C16:0), palmitoleic acid (PO; C16:1), stearic acid (SA; C18:0), and oleic acid (OA; C18:1). Using pure molecules, we show that all of these fatty acids induce NETosis to different degrees in a dose-dependent fashion. Notably, F6 induces a unique form of NETosis that is rapid and induces reactive oxygen species (ROS) production by both NADPH oxidase (NOX) and mitochondria. F6 also induces citrullination of histone. By contrast, the common fatty acids (PA, PO, SA, and OA) only induce NOX-dependent NETosis. The activation of the kinases such as ERK (extracellular signal-regulated kinase) and JNK (c-Jun N-terminal kinase) is important for long-chain fatty acid-induced NETosis, whereas, in F-acid-induced NETosis, Akt is additionally needed. Nevertheless, NETosis induced by all of these compounds requires the final chromatin decondensation step of transcriptional firing. These findings are useful for understanding F-acid- and other fatty acid-induced NETosis and to establish the active ingredients with therapeutic potential for regulating diseases involving NET formation.

Curcumin ameliorates protein expression changes involved in mitochondrial fatty acids metabolism in heart of mice fed a high-fructose diet

2020 ◽  
Author(s):  
Cecilia Gabriela Meléndez-Salcido ◽  
Katya Vargas-Ortiz ◽  
Oscar Gerardo Silva-Gaona ◽  
María Cristina León-García ◽  
Luz Arcelia Ortega-Hernández ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Beneficial Effect ◽  
Therapeutic Potential ◽  
Cardiometabolic Disease ◽  
Control Group ◽  
Standard Diet ◽  
High Fructose Diet ◽  
High Fructose ◽  
Fatty Acids Metabolism

Abstract Background: It has been proposed that curcumin modulates the gene expression of different signaling pathways, improve the fatty acids metabolism and exerts a potential beneficial effect on cardiometabolic disease, but this has not been thoroughly demonstrated. In the present study, we evaluated the effect of curcumin upon the expression of PPARα, CPT1, MCAD, VLCAD and ACAA2 in heart of mice fed a high-fructose diet (HFD). Methods: Twenty-four mice C57BL/6 were divided into four groups (n=6) and treated for 15 weeks. Control group (C) received standard diet (SD), Curcumin group (C+Cur), Fructose group (F) and Fructose with Curcumin group (F+Cur). The groups were treated with 0.75% w/w curcumin mixed in the SD and 30% w/v fructose in water, respectively. Heart proteins expression were analyzed by Western Blot. Results: Curcumin supplementation increased PPARα and ACAA2 expression and decreased CPT1 and MCAD expression in heart of mice fed a HFD. However, it did not modify the VLCAD expression. Conclusions: Curcumin regulated PPARα, CPT1 and MCAD expression and increased ACAA2 expression; suggesting a therapeutic potential in the prevention of alterations in mitochondrial fatty acids metabolism in heart of mice fed a HFD.

The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease

2011 ◽  
Vol 30 (1) ◽  
pp. 6-19 ◽  
Author(s):  
Haim Shapiro ◽  
Miryam Tehilla ◽  
Joelle Attal-Singer ◽  
Rafael Bruck ◽  
Rachel Luzzatti ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Therapeutic Potential ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Nonalcoholic Fatty Liver ◽  
Long Chain

scholarly journals Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators

2020 ◽  
Author(s):  
Debasis Mondal ◽  
Devin Narwani ◽  
Shahnawaz Notta ◽  
Dawood Ghaffar ◽  
Nikhil Mardhekar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Therapeutic Potential ◽  
Redox Signaling

Potentiation of polyunsaturated fatty acids anti-inflammatory action through redox signaling in fructose-treated endothelial cells

2021 ◽  
Vol 177 ◽  
pp. S79
Author(s):  
Bojana Mićić ◽  
Marina Nikolić ◽  
Gordana Tovilović Kovačević ◽  
Ana Teofilović ◽  
Ljupka Gligorovska ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Endothelial Cells ◽  
Polyunsaturated Fatty Acids ◽  
Redox Signaling ◽  
Anti Inflammatory ◽  
Inflammatory Action

Fatty acids and their therapeutic potential in neurological disorders

2016 ◽  
Vol 95 ◽  
pp. 75-84 ◽  
Author(s):  
Enie Lei ◽  
Kristina Vacy ◽  
Wah Chin Boon
Keyword(s):  
Fatty Acids ◽  
Neurological Disorders ◽  
Therapeutic Potential

scholarly journals Super Critical Fluid Extracted Fatty Acids from Withania somnifera Seeds Repair Psoriasis-Like Skin Lesions and Attenuate Pro-Inflammatory Cytokines (TNF-α and IL-6) Release

Biomolecules ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 185 ◽  
Author(s):  
Acharya Balkrishna ◽  
Pradeep Nain ◽  
Anshul Chauhan ◽  
Niti Sharma ◽  
Abhishek Gupta ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Inflammatory Cytokines ◽  
Withania Somnifera ◽  
Therapeutic Potential ◽  
Skin Lesions ◽  
Luciferase Reporter ◽  
Plant Parts ◽  
Tnf Α ◽  
Psoriatic Lesions ◽  
Pro Inflammatory Cytokines

(1) Background: Withania somnifera Dunal (Ashwagandha) is a widely used medicinal herb in traditional medicinal systems with extensive research on various plant parts. Surprisingly, seeds of W. somnifera have never been investigated for their therapeutic potential. (2) Methods: W. somnifera seeds were extracted for fatty acids (WSSO) using super critical fluid extraction, and was analyzed by gas chromatography. Its therapeutic potential in psoriasis-like skin etiologies was investigated using a 12-O tetradecanoyl phorbol 13-acetate (TPA)-induced psoriatic mouse model. Psoriatic inflammation along with psoriatic lesions and histopathological scores were recorded. WSSO was also tested on murine macrophage (RAW264.7), human epidermoid (A431), and monocytic (THP-1) cells, stimulated with TPA or lipo poly-saccharide (LPS) to induce pro-inflammatory cytokine (IL-6 and TNF-α) release. NFκB promoter activity was also measured by luciferase reporter assay. (3) Results: Topical application of WSSO with concurrent oral doses significantly reduced inflammation-induced edema, and repaired psoriatic lesions and associated histopathological scores. Inhibition of pro-inflammatory cytokines release was observed in WSSO-treated A431 and THP-1 cells, along with reduced NFκB expression. WSSO also inhibited reactive nitrogen species (RNS) in LPS-stimulated RAW264.7 cells. (4) Conclusion: Here we show that the fatty acids from W. somnifera seeds have strong anti-inflammatory properties, along with remarkable therapeutic potential on psoriasis-like skin etiologies.

scholarly journals The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer

2020 ◽  
Vol 11 ◽  
Author(s):  
Matthias Piesche ◽  
Jessica Roos ◽  
Benjamin Kühn ◽  
Jasmin Fettel ◽  
Nadine Hellmuth ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Therapeutic Potential ◽  
Michael Acceptor

scholarly journals Commercial and Therapeutic Potential of Plant-Based Fatty Acids

2018 ◽  
Author(s):  
Ana Paula de Souza e Silva ◽  
Wanessa Almeida da Costa ◽  
Marielba de Los Angeles Rodriguez Salazar ◽  
Priscila do Nascimento Bezerra ◽  
Flávia Cristina Seabra Pires ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Therapeutic Potential
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