scholarly journals Identification of Michael Acceptor-Centric Pharmacophores with Substituents That Yield Strong Thioredoxin Reductase Inhibitory Character Correlated to Antiproliferative Activity

2013 ◽  
Vol 19 (11) ◽  
pp. 1149-1165 ◽  
Author(s):  
Fei-Fei Gan ◽  
Kamila K. Kaminska ◽  
Hong Yang ◽  
Chin-Yee Liew ◽  
Pay-Chin Leow ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Thioredoxin Reductase ◽  
Michael Acceptor

Thioredoxin reductase inhibition by antitumor quinols: a quinol pharmacophore effect correlating to antiproliferative activity

2008 ◽  
Vol 22 (6) ◽  
pp. 2072-2083 ◽  
Author(s):  
Eng‐Hui Chew ◽  
Jun Lu ◽  
Tracey D. Bradshaw ◽  
Arne Holmgren
Keyword(s):  
Antiproliferative Activity ◽  
Thioredoxin Reductase

GALLIC ACID HYDRAZONES: ‘IN SILICO’ INHIBITION OF THIOREDOXIN REDUCTASE

2021 ◽  
Author(s):  
Jovica Branković ◽  
◽  
Vesna Milovanović ◽  
Zorica D. Petrović ◽  
Vladimir P. Petrović
Keyword(s):  
Gallic Acid ◽  
Antiproliferative Activity ◽  
Inhibitory Activity ◽  
In Silico ◽  
Thioredoxin Reductase ◽  
The Other ◽  
Redox Equilibrium ◽  
Other Hand ◽  
Thioredoxin System

Gallic hydrazones, as gallic acid derivatives, are known as pharmacophores of numerous multipotent agents. Among them, antiproliferative activity is one of the most important. On the other hand, thioredoxin reductase (TrxR1) is a part of the thioredoxin system, one of the most important systems responsible for maintaining the redox equilibrium inside the cell. It is overexpressed in different forms of tumors. Bearing this in mind, TrxR1 is a valid target for the development of compounds with potential antiproliferative activity. For this purpose, eight gallic acid-based hydrazones are selected and examined in silico for their potential inhibitory activity towards TrxR1.

Water soluble palladium(ii) and platinum(ii) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

2020 ◽  
Vol 44 (15) ◽  
pp. 5762-5773 ◽  
Author(s):  
Tatiyana V. Serebryanskaya ◽  
Mikhail A. Kinzhalov ◽  
Vladimir Bakulev ◽  
Georgii Alekseev ◽  
Anastasiya Andreeva ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antiproliferative Activity ◽  
Water Soluble ◽  
Solution Behavior ◽  
Antitumor Potential ◽  
Acyclic Diaminocarbene

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.

In vitro and in vivo antiproliferative activity of arucanolide isolated from Calea pinnatifida

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
G Marchetti ◽  
K Silva ◽  
A Ruiz ◽  
I Sousa ◽  
S Tinti ◽  
...  
Keyword(s):  
Antiproliferative Activity

Selective antiproliferative activity of spinasterol from Physospemum verticillatum against A549 and COR-L23 cancer cells

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
R Tundis ◽  
B Deguin ◽  
MR Loizzo ◽  
M Bonesi ◽  
S Michel ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Antiproliferative Activity

Sesquiterpenes from Neurolaena lobata with antiproliferative activity

2017 ◽  
Author(s):  
A Vasas ◽  
I Lajter ◽  
P Forgó ◽  
N Kúsz ◽  
N Bózsity ◽  
...  
Keyword(s):  
Antiproliferative Activity
Sign in / Sign up

Export Citation Format

Share Document