Ferric Iron and Cobalt (III) Compounds to Safely Decrease Hydrogen Sulfide in the Body?

2013 ◽  
Vol 19 (5) ◽  
pp. 510-516 ◽  
Author(s):  
Andry Van de Louw ◽  
Philippe Haouzi
Keyword(s):  
Hydrogen Sulfide ◽  
Ferric Iron ◽  
The Body

scholarly journals Fighting Oxidative Stress with Sulfur: Hydrogen Sulfide in the Renal and Cardiovascular Systems

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 373
Author(s):  
Joshua J. Scammahorn ◽  
Isabel T. N. Nguyen ◽  
Eelke M. Bos ◽  
Harry Van Goor ◽  
Jaap A. Joles
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Sulfide ◽  
Redox Status ◽  
The Body ◽  
Therapeutic Interventions ◽  
Oxygen Species ◽  
Enzymatic Production ◽  
Age Related ◽  
Anti Oxidant ◽  
Enzymatic Pathways

Hydrogen sulfide (H2S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration and cysteine catabolism pathways can occur in the kidneys and blood vessels. Furthermore, non-enzymatic pathways are present throughout the body. In the renal and cardiovascular system, H2S plays an important role in maintaining the redox status at safe levels by promoting scavenging of reactive oxygen species (ROS). H2S also modifies cysteine residues on key signaling molecules such as keap1/Nrf2, NFκB, and HIF-1α, thereby promoting anti-oxidant mechanisms. Depletion of H2S is implicated in many age-related and cardiorenal diseases, all having oxidative stress as a major contributor. Current research suggests potential for H2S-based therapies, however, therapeutic interventions have been limited to studies in animal models. Beyond H2S use as direct treatment, it could improve procedures such as transplantation, stem cell therapy, and the safety and efficacy of drugs including NSAIDs and ACE inhibitors. All in all, H2S is a prime subject for further research with potential for clinical use.

scholarly journals Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Mingzhe Liu ◽  
Lingyun Wu ◽  
Sabine Montaut ◽  
Guangdong Yang
Keyword(s):  
Prostate Cancer ◽  
Hydrogen Sulfide ◽  
Cancer Cells ◽  
Current Knowledge ◽  
Cancer Therapeutics ◽  
The Body ◽  
Health Concern ◽  
Diallyl Disulfide ◽  
Castration Resistant Prostate Cancer ◽  
Prostate Cancer Cells

Hydrogen sulfide (H2S) was originally considered toxic at elevated levels; however just in the past decade H2S has been proposed to be an important gasotransmitter with various physiological and pathophysiological roles in the body. H2S can be generated endogenously from L-cysteine by multiple enzymes, including cystathionine gamma-lyase, cystathionine beta-synthase, and 3-mercaptopyruvate sulfurtransferase in combination with cysteine aminotransferase. Prostate cancer is a major health concern and no effective treatment for prostate cancers is available. H2S has been shown to inhibit cell survival of androgen-independent, androgen-dependent, and antiandrogen-resistant prostate cancer cells through different mechanisms. Various H2S-releasing compounds, including sulfide salts, diallyl disulfide, diallyl trisulfide, sulforaphane, and other polysulfides, also have been shown to inhibit prostate cancer growth and metastasis. The expression of H2S-producing enzyme was reduced in both human prostate cancer tissues and prostate cancer cells. Androgen receptor (AR) signaling is indispensable for the development of castration resistant prostate cancer, and H2S was shown to inhibit AR transactivation and contributes to antiandrogen-resistant status. In this review, we summarized the current knowledge of H2S signaling in prostate cancer and described the molecular alterations, which may bring this gasotransmitter into the clinic in the near future for developing novel pharmacological and therapeutic interventions for prostate cancer.

scholarly journals Production of Hydrogen Sulfide by Fermentation in Rumen and Its Impact on Health and Production of Animals

Processes ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1169
Author(s):  
Ali Mujtaba Shah ◽  
Jian Ma ◽  
Zhisheng Wang ◽  
Rui Hu ◽  
Xueying Wang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Animal Health ◽  
Rumen Fermentation ◽  
Intestinal Wall ◽  
Vital Role ◽  
The Body ◽  
Sulfide Concentration ◽  
Production Of Hydrogen

Hydrogen sulfide is a Janus-faced molecule with many beneficial and toxic effects on the animal health. In ruminants, rumen fermentation plays a vital role in the digestion and absorption of nutrients. During rumen fermentation, the production of hydrogen sulfide can occur, and it can be rapidly absorbed into the body of the animals through the intestinal wall. If the production of hydrogen sulfide concentration is higher in the rumen, it can cause a toxic effect on ruminants known as poliomyelitis. The production of hydrogen sulfide depends on the population of sulfate-reducing bacteria in the rumen. In rodents, H2S maintains the normal physiology of the gastrointestinal tract and also improves the healing of the chronic gastric ulcer. In the gut, H2S regulates physiological functions such as inflammation, ischemia–reperfusion injury and motility. In this review article, we summarize the toxicity occurrence in the body of animals due to high levels of hydrogen sulfide production and also recent progress in the studies of physiological function of H2S in the gut, with a special emphasis on bacteria-derived H2S is discussed in this review.

scholarly journals The content of gas transmitters in umbilical cord blood and blood of newborns born to mothers with preeclampsia

2021 ◽  
Vol 66 (4) ◽  
pp. 53-57
Author(s):  
I. G. Popova ◽  
O. G. Sitnikova ◽  
S. B. Nazarov ◽  
G. N. Kuzmenko ◽  
M. M. Klychevа ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Life Support ◽  
Venous Blood ◽  
The Body ◽  
Control Group ◽  
Control Groups ◽  
And Control

To assess endothelial function in the newborns born to mothers with preeclampsia and without preeclampsia the scientists assessed the content of nitricoxide and hydrogen sulfide in the umbilical and venous blood of these children. The main group consisted of 80 women with moderate preeclampsia and their80 newborns; the control group included 50 children born to women without preeclampsia. The authors studied the content of nitric oxide by determining the totalnitrates and nitrites (NOx), hydrogen sulfide in mixed cord blood collected within 30 minutes after delivery, and venous blood taken from newborns on the 1-3rd day of life. Umbilical cord blood demonstrated no significant differences in the content of NO xand hydrogen sulfide in newborns of the main and control groups. However, in general, the study of umbilical cord blood revealed a relationship between the concentration of hydrogen sulfide and the possibility of developing intraventricular hemorrhagein a newborn of the main and control groups. In the venous blood there was a significant increase in the content of NOx and hydrogen sulfide in newborns born to mothers with preeclampsia. It may cause vasodilation asa compensatory reaction of the body during the period of postnatal adaptation of the child’s body, aimed at life support.

scholarly journals Intravaginal use of clindamycin phosphate in therapy of bacterial vaginosis: peculiarities of pharmacokinetics depending on the level of hydrogen sulfide in the organism (literature review)

2020 ◽  
Vol 24 (4) ◽  
pp. 726-731
Author(s):  
D. I. Grebeniuk ◽  
I. V. Taran ◽  
O. A. Nazarchuk
Keyword(s):  
Hydrogen Sulfide ◽  
Bacterial Vaginosis ◽  
Background Level ◽  
Potential Effect ◽  
Preclinical Study ◽  
The Body ◽  
Pharmacological Properties ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Clindamycin Phosphate ◽  
Physiological Processes

Annotation. The article provides an overview of modern literature data on the problems of bacterial vaginosis, its therapy with clindamycin, the pharmacokinetics of this pharmacological drug, and the potential effect of the background level of hydrogen sulfide in the body on the pharmacokinetics of drugs. From PubMed, ScienceDirect, UpToDate databases, 50 sources were selected that met the conditions of the query: the latest publications (for the last 5 years), or the latest publications on this issue (regardless of age). The wide and diverse influence of endogenous hydrogen sulfide on the course of biochemical and physiological processes in the body prompts the study of its potential modulating effect on the pharmacological properties of drugs. A preclinical study of the pharmacokinetics and pharmacodynamics of drugs (in particular, clindamycin) will further optimize therapeutic regimens taking into account the level of hydrogen sulfide in the body, as well as create the preconditions for the development of new effective pharmaceutical compositions of antibiotics and hydrogen sulfide donors.

scholarly journals Determination of ammonia and hydrogen sulfide emissions from a commercial dairy farm with an exercise yard and the health-related impact for residents

2020 ◽  
Vol 27 (30) ◽  
pp. 37684-37698 ◽  
Author(s):  
Chuandong Wu ◽  
Fan Yang ◽  
Marlon Brancher ◽  
Jiemin Liu ◽  
Chen Qu ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Health Risk ◽  
Body Mass ◽  
Dairy Farm ◽  
The Body ◽  
Ammonia Emission ◽  
Emission Rates ◽  
Contour Lines ◽  
Health Related ◽  
Fence Line

Abstract Airborne emissions from concentrated animal feeding operations (CAFOs) have the potential to pose a risk to human health and the environment. Here, we present an assessment of the emission, dispersion, and health-related impact of ammonia and hydrogen sulfide emitted from a 300-head, full-scale dairy farm with an exercise yard in Beijing, China. By monitoring the referred gas emissions with a dynamic flux chamber for seven consecutive days, we examined their emission rates. An annual hourly emission time series was constructed on the basis of the measured emission rates and a release modification model. The health risk of ammonia and hydrogen sulfide emissions around the dairy farm was then determined using atmospheric dispersion modeling and exposure risk assessment. The body mass-related mean emission factors of ammonia and hydrogen sulfide were 2.13 kg a−1 AU−1 and 24.9 g a−1 AU−1, respectively (one animal unit (AU) is equivalent to 500 kg body mass). A log-normal distribution fitted well to ammonia emission rates. Contour lines of predicted hourly mean concentrations of ammonia and hydrogen sulfide were mainly driven by the meteorological conditions. The concentrations of ammonia and hydrogen sulfide at the fence line were below 10 μg m−3 and 0.04 μg m−3, respectively, and were 2–3 orders of magnitude lower than the current Chinese air quality standards for such pollutants. Moreover, the cumulative non-carcinogenic risks (HI) of ammonia and hydrogen sulfide were 4 orders of magnitudes lower than the acceptable risk levels (HI = 1). Considering a health risk criterion of 1E-4, the maximum distance from the farm fence line to meet this criterion was nearly 1000 m towards north-northeast. The encompassed area of the contour lines of the ambient concentration of ammonia is much larger than that of hydrogen sulfide. However, the contour lines of the ammonia health risk are analogous to those of hydrogen sulfide. In general, the ammonia and hydrogen sulfide emissions from the dairy farm are unlikely to cause any health risks for the population living in the neighborhood.

Bioavailability of Iron and Cyanide from 59Fe-and 14C-Labelled Hexacyanoferrates(II) in Rats

1990 ◽  
Vol 45 (6) ◽  
pp. 681-690 ◽  
Author(s):  
Peter Nielsen ◽  
Bernd Dresow ◽  
Roland Fischer ◽  
Hellmuth C. Heinrich
Keyword(s):  
Oral Administration ◽  
Prussian Blue ◽  
Ferrous Iron ◽  
Intestinal Tract ◽  
Ferric Iron ◽  
The Body ◽  
Female Rats ◽  
Exhaled Air ◽  
Severe Nuclear Accident

Abstract “Soluble” (KFeIII[FeII(CN )6]) and “insoluble Prussian blue” (FeIII4[FeII(CN)6]3 labelled with 59Fe either in the ferric (FeIII) or ferro (FeII) position and 14C in the cyanide group were synthesized and administered intraperitoneally or orally to adult female rats with normal body iron stores. Following i.p. injection of KFe[Fe(CN)6], the colloidal complex is disintegrated into ferric iron and hexacyanoferrate(II) anion almost completely. About 96% of the ferric iron was retained in the body. Nearly 90% of both ferrous iron and cyanide were excreted with the urine within 7 days after i.p. injection, indicating that most of the undissociated hexacyanoferrate(II) anion ([Fe(CN)6]4-) was excreted through the kidney. Only 9% of the ferrous iron from [Fe(CN)6]4- was found mainly in carcass, liver and gut. As the 59Fe/14C-ratios in organs were found close to 1.0, the dissociation of the hexacyanoferrate(II) anion can only be small in vivo. No detectable 14CO2-activity (< 0.01 %) was monitored in the breath of rats after i.p. injection of the 14C-labelled KFe[Fe(CN)6], also indicating that no significant amounts of cyanide were released after parenteral administration. After oral administration of the soluble and insoluble Prussian blue, 0 .3 -0 .7% of the ferric iron was absorbed and retained mainly in carcass, liver and blood. Only 0.06-0.18% of the ferrous iron was absorbed and mostly excreted with the urine (0.05-0.15%), so that only 0.01-0.03% of the oral ferrous 59Fe was retained in the body after 7- 10 days. Very small fractions of 14C-label from the 14CN-group of the soluble and insoluble hexacyanoferrate(II) were observed in the exhaled air (0.04-0.08% of the oral dose). From the 14CO2-exhalation, the 14Curine excretion and the distribution of iron in blood and organs it can be concluded that the hexacyanoferrate(II) moiety disintegrated only to a small extent in the intestinal tract after oral administration. From a dose of 36 mg hexacyanoferrate(II)/kg, an amount of free (non complex bound) cyanide can be calculated which is in maximum two orders of magnitude below the LD100-level. Thus, the very low bioavailability of iron and cyanide from hexacyanoferrate(II) compounds after oral application is demonstrated in rats. In the case of a severe nuclear accident, appropriate doses of “soluble” and “insoluble” Prussian blue can be used as safe and effective antidote against radiocaesium contamination.

scholarly journals Role of hydrogen sulfide and polysulfides in neurological diseases: focus on protein S-Persulfidation

2020 ◽  
Vol 18 ◽  
Author(s):  
Hai-Jian Sun ◽  
Zhi-Yuan Wu ◽  
Xiao-Wei Nie ◽  
Jin-Song Bian
Keyword(s):  
Hydrogen Sulfide ◽  
Protein Modification ◽  
Neurological Diseases ◽  
Protein S ◽  
The Body ◽  
Memory Decline ◽  
Target Proteins ◽  
Therapeutic Development ◽  
The Central Nervous System

: Hydrogen sulfide (H2S) and hydrogen polysulfides are recognized as important signaling molecules that are generated physiologically in the body, including the central nervous system (CNS). Studies have shown that these two molecules are involved in cytoprotection against oxidative stress and inflammatory response. In the brain system, H2S and polysulfides exert multiple functions in both health and diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington's disease (HD), memory decline, and glioma. Mechanistically, S-Persulfidation (also known as S-sulfuration or S-sulfhydration) of target proteins is believed to be a fundamental mechanism that underlies H2S-regulated signaling pathways. Cysteine S-Persulfidation is an important paradigm of post-translational protein modification in the process of H2S signaling. This model is established as a critical redox mechanism to regulate numerous biological functions, especially in H2S-mediated neuroprotection and neurogenesis. Although the current research of S-Persulfidation is still in its infancy, accumulative evidence suggests that protein S-Persulfidation may share similar characteristics with protein S-nitrosylation. In this review, we will provide a comprehensive insight into the S-Persulfidation biology of H2S and polysulfides in neurological ailments and presume potential avenues for therapeutic development in these disorders based on S-Persulfidation of target proteins.

The body wall of Halicryptus spinulosus (Priapulida) — ultrastructure and changes induced by hydrogen sulfide

Hydrobiologia ◽  
1992 ◽  
Vol 230 (3) ◽  
pp. 219-230 ◽  
Author(s):  
Hans Heinrich Janssen ◽  
Rolf Oeschger
Keyword(s):  
Hydrogen Sulfide ◽  
Body Wall ◽  
The Body

scholarly journals THE EFFECT OF DIFFERENT LEVELS OF THE BODY SATURATION WITH HYDROGEN SULFIDE ON THE TOXICITY OF LINCOSAMIDES

2021 ◽  
Vol 2 (1) ◽  
pp. 132
Author(s):  
I. V. Taran ◽  
N. I. Voloshchuk ◽  
D. I. Grebeniuk ◽  
M. S. Lozinska ◽  
O. A. Nazarchuk
Keyword(s):  
Hydrogen Sulfide ◽  
The Body ◽  
Different Levels
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