Mitogen-Activated Protein Kinases in Mammalian Oxidative Stress Responses

2011 ◽  
Vol 15 (1) ◽  
pp. 205-218 ◽  
Author(s):  
Christopher Runchel ◽  
Atsushi Matsuzawa ◽  
Hidenori Ichijo
Keyword(s):  
Oxidative Stress ◽  
Protein Kinases ◽  
Stress Responses ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Oxidative Stress Responses

scholarly journals Neuroprotective Effects of Tetrahydrocurcumin against Glutamate-Induced Oxidative Stress in Hippocampal HT22 Cells

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 144 ◽  
Author(s):  
Chang-Hyun Park ◽  
Ji Hoon Song ◽  
Su-Nam Kim ◽  
Ji Hwan Lee ◽  
Hae-Jeung Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Protein Kinases ◽  
Apoptotic Cell ◽  
Curcuma Longa ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Ht22 Cells ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

In the central nervous system, glutamate is a major excitable neurotransmitter responsible for many cellular functions. However, excessive levels of glutamate induce neuronal cell death via oxidative stress during acute brain injuries as well as chronic neurodegenerative diseases. The present study was conducted to examine the effect of tetrahydrocurcumin (THC), a major secondary metabolite of curcumin, and its possible mechanism against glutamate-induced cell death. We prepared THC using curcumin isolated from Curcuma longa (turmeric) and demonstrated the protective effect of THC against glutamate-induced oxidative stress in HT22 cells. THC abrogated glutamate-induced HT22 cell death and showed a strong antioxidant effect. THC also significantly reduced intracellular calcium ion increased by glutamate. Additionally, THC significantly reduced the accumulation of intracellular oxidative stress induced by glutamate. Furthermore, THC significantly diminished apoptotic cell death indicated by annexin V-positive in HT22 cells. Western blot analysis indicated that the phosphorylation of mitogen-activated protein kinases including c-Jun N-terminal kinase, extracellular signal-related kinases 1/2, and p38 by glutamate was significantly diminished by treatment with THC. In conclusion, THC is a potent neuroprotectant against glutamate-induced neuronal cell death by inhibiting the accumulation of oxidative stress and phosphorylation of mitogen-activated protein kinases.

scholarly journals Mitogen-activated protein kinases are involved in hepatocanalicular dysfunction and cholestasis induced by oxidative stress

2016 ◽  
Vol 91 (6) ◽  
pp. 2391-2403 ◽  
Author(s):  
Flavia D. Toledo ◽  
Cecilia L. Basiglio ◽  
Ismael R. Barosso ◽  
Andrea C. Boaglio ◽  
Andrés E. Zucchetti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Kinases ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein

scholarly journals The Heat Shock Factor A4A Confers Salt Tolerance and Is Regulated by Oxidative Stress and the Mitogen-Activated Protein Kinases MPK3 and MPK6

2014 ◽  
Vol 165 (1) ◽  
pp. 319-334 ◽  
Author(s):  
Imma Pérez-Salamó ◽  
Csaba Papdi ◽  
Gábor Rigó ◽  
Laura Zsigmond ◽  
Belmiro Vilela ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Salt Tolerance ◽  
Protein Kinases ◽  
Heat Shock Factor ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein
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