Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

2009 ◽  
Vol 11 (10) ◽  
pp. 2409-2427 ◽  
Author(s):  
Célio X.C. Santos ◽  
Leonardo Y. Tanaka ◽  
João Wosniak ◽  
Francisco R.M. Laurindo
Keyword(s):  
Reactive Oxygen Species ◽  
Endoplasmic Reticulum ◽  
Electron Transport ◽  
Nadph Oxidase ◽  
Unfolded Protein Response ◽  
Reactive Oxygen Species Generation ◽  
Oxygen Species ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals Interplay between the unfolded protein response and reactive oxygen species: a dynamic duo

2018 ◽  
Vol 69 (14) ◽  
pp. 3333-3345 ◽  
Author(s):  
Rengin Ozgur ◽  
Baris Uzilday ◽  
Yuji Iwata ◽  
Nozomu Koizumi ◽  
Ismail Turkan
Keyword(s):  
Reactive Oxygen Species ◽  
Unfolded Protein Response ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane.

1997 ◽  
Vol 8 (9) ◽  
pp. 1805-1814 ◽  
Author(s):  
J S Cox ◽  
R E Chapman ◽  
P Walter
Keyword(s):  
Endoplasmic Reticulum ◽  
Unfolded Protein Response ◽  
Secretory Pathway ◽  
Lipid Synthesis ◽  
Secretory Proteins ◽  
Endoplasmic Reticulum Membrane ◽  
Yeast Saccharomyces Cerevisiae ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

The endoplasmic reticulum (ER) is a multifunctional organelle responsible for production of both lumenal and membrane components of secretory pathway compartments. Secretory proteins are folded, processed, and sorted in the ER lumen and lipid synthesis occurs on the ER membrane itself. In the yeast Saccharomyces cerevisiae, synthesis of ER components is highly regulated: the ER-resident proteins by the unfolded protein response and membrane lipid synthesis by the inositol response. We demonstrate that these two responses are intimately linked, forming different branches of the same pathway. Furthermore, we present evidence indicating that this coordinate regulation plays a role in ER biogenesis.

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