GPx2 Counteracts PGE2 Production by Dampening COX-2 and mPGES-1 Expression in Human Colon Cancer Cells

2008 ◽  
Vol 10 (9) ◽  
pp. 1491-1500 ◽  
Author(s):  
Antje Banning ◽  
Simone Florian ◽  
Stefanie Deubel ◽  
Sophie Thalmann ◽  
Katrin Müller-Schmehl ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Pge2 Production ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Cox 2 ◽  
Human Colon Cancer Cells

scholarly journals Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation

2017 ◽  
Vol 23 (7) ◽  
pp. 1171 ◽  
Author(s):  
Hsi-Hsien Hsu ◽  
Ming-Cheng Chen ◽  
Cecilia Hsuan Day ◽  
Yueh-Min Lin ◽  
Shin-Yi Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prostaglandin E2 ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Cox 2 ◽  
Human Colon Cancer Cells

Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway

2012 ◽  
Vol 90 (4) ◽  
pp. 521-531 ◽  
Author(s):  
Jun Ha ◽  
Li Zhao ◽  
Qing Zhao ◽  
Jing Yao ◽  
Bin-Bin Zhu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Synergistic Effect ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Oroxylin A ◽  
Human Colon Cancer ◽  
Cox 2 ◽  
Human Colon Cancer Cells ◽  
Ht 29

5-Fluorouracil (5-FU) is a principal drug for the treatment of colorectal cancer. Due to its low response and high toxicity, synergistic effects of 5-FU in combination with other drugs have been widely researched. This study investigated whether oroxylin A improved the sensitivity of HT-29 human colon cancer cells to 5-FU. A correlation between COX-2 inhibition by oroxylin A and a synergistic effect of 5-FU on the growth of HT-29 cells was observed, and a COX-2 pathway for this effect was recognized; oroxylin A evidently elevated the level of reactive oxygen species in HT-29 cells, which subsequently inhibited COX-2 expression and enhanced the susceptibility of HT-29 cells to 5-FU. Likely also related to COX-2 inhibition, oroxylin A decreased PGE2 levels in HT-29 cells. The synergistic effect of 5-FU induced by oroxylin A was also found in the suppression of Bcl-2 and in the activation of P53, Bax, PARP, and procaspase-3 proteins in HT-29 cells. Ultimately, a combination of 5-FU with oroxylin A significantly reduced the growth of HT-29 tumors in nude mice compared with treatment with 5-FU or oroxylin A alone. In conclusion, a combination of 5-FU and oroxylin A has a significant synergistic effect in the inhibition of HT-29 cell proliferation in vitro and controls HT-29 tumor growth in vivo. This synergistic effect may be mainly related to COX-2 inhibition by oroxylin A in HT-29 cells.

scholarly journals n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE 2 induced ERK-1 and -2 and HIF-1α induction pathway

2004 ◽  
Vol 25 (12) ◽  
pp. 2303-2310 ◽  
Author(s):  
Gabriella Calviello ◽  
Fiorella Di Nicuolo ◽  
Simona Gragnoli ◽  
Elisabetta Piccioni ◽  
Simona Serini ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Vegf Expression ◽  
Human Colon Cancer ◽  
Cox 2 ◽  
Human Colon Cancer Cells
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