Proteomics Analyses of Specific Protein Oxidation and Protein Expression in Aged Rat Brain and Its Modulation by L-Acetylcarnitine: Insights Into the Mechanisms of Action of This Proposed Therapeutic Agent for CNS Disorders Associated with Oxidative Stress

2006 ◽  
Vol 8 (3-4) ◽  
pp. 381-394 ◽  
Author(s):  
H. Fai Poon ◽  
Vittorio Calabrese ◽  
Menotti Calvani ◽  
D. Allan Butterfield
Keyword(s):  
Oxidative Stress ◽  
Protein Expression ◽  
Rat Brain ◽  
Protein Oxidation ◽  
Therapeutic Agent ◽  
Specific Protein ◽  
Mechanisms Of Action ◽  
Cns Disorders ◽  
Aged Rat

scholarly journals Effects of UVB-induced oxidative stress on protein expression and specific protein oxidation in normal human epithelial keratinocytes: a proteomic approach

2010 ◽  
Vol 8 (1) ◽  
pp. 13 ◽  
Author(s):  
Marzia Perluigi ◽  
Fabio Di Domenico ◽  
Carla Blarzino ◽  
Cesira Foppoli ◽  
Chiara Cini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Expression ◽  
Protein Oxidation ◽  
Specific Protein ◽  
Proteomic Approach ◽  
Normal Human

scholarly journals Isoflurane/nitrous oxide anesthesia induces increases in NMDA receptor subunit NR2B protein expression in the aged rat brain

2012 ◽  
Vol 1431 ◽  
pp. 23-34 ◽  
Author(s):  
Lana J. Mawhinney ◽  
Juan Pablo de Rivero Vaccari ◽  
Ofelia F. Alonso ◽  
Christopher A. Jimenez ◽  
Concepción Furones ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Nmda Receptor ◽  
Protein Expression ◽  
Rat Brain ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit ◽  
Aged Rat ◽  
Oxide Anesthesia

scholarly journals Overview of Salvia miltiorrhiza as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 857
Author(s):  
Inyong Jung ◽  
Hyerin Kim ◽  
Seongcheol Moon ◽  
Hyuk Lee ◽  
Bonglee Kim
Keyword(s):  
Oxidative Stress ◽  
Therapeutic Agent ◽  
Salvia Miltiorrhiza ◽  
Cerebrovascular Diseases ◽  
Mechanisms Of Action ◽  
Therapeutic Effects ◽  
Nervous System Diseases ◽  
Salvia Miltiorrhiza Bunge ◽  
Pubmed Central ◽  
Therapeutic Benefits

Salvia miltiorrhiza Bunge (S. miltiorrhiza) is a medicinal herb that has been used for the treatment for various diseases such as cardiovascular and cerebrovascular diseases in East Asia including Korea. Considering its extensive usage as a therapeutic agent for multiple diseases, there is a need to review previous research regarding its therapeutic benefits and their mechanisms. Therefore, we searched PubMed and PubMed Central for articles reporting its therapeutic effects on certain disease groups including cancers, cardiovascular, liver, and nervous system diseases. This review provides an overview of therapeutic benefits and targets of S. miltiorrhiza, including inflammation, fibrosis, oxidative stress, and apoptosis. The findings on multi-functional properties of S. miltiorrhiza discussed in this article support the efficacy of S. miltiorrhiza extract on various diseases, but also call for further research on the multiple mechanisms that mediate its therapeutic effects.

scholarly journals Attenuated transcriptional responses to oxidative stress in the aged rat brain

2002 ◽  
Vol 70 (3) ◽  
pp. 318-326 ◽  
Author(s):  
LiQi Tong ◽  
Tracy Toliver-Kinsky ◽  
Michael Edwards ◽  
David K. Rassin ◽  
Karin Werrbach-Perez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Transcriptional Responses ◽  
Aged Rat

Ellagic Acid: A Logical Lead for Drug Development?

2018 ◽  
Vol 24 (2) ◽  
pp. 106-122 ◽  
Author(s):  
Abolfazl Shakeri ◽  
Mohammad Reza Zirak ◽  
Amirhossein Sahebkar
Keyword(s):  
Oxidative Stress ◽  
Ellagic Acid ◽  
Therapeutic Agent ◽  
Biological Activities ◽  
Biological Properties ◽  
Mechanisms Of Action ◽  
Human Diseases ◽  
Pharmacological Properties ◽  
Naturally Occurring ◽  
The Subject

Background: Naturally occurring polyphenols are the subject of increasing attention due to their potent antioxidant activity and their marked effects on the prevention of various oxidative stress-associated diseases such as cancer. Ellagic acid (EA) is an herbal polyphenol that is structurally a condensed dimer of gallic acid. Methods: This review aims to provide a comprehensive and updated overview on the biological activities of EA and potential therapeutic applications. Results: EA is found in fruits and nuts, either in the combined form with hexahydroxydiphenic acid or in the bound form (ellagitannins). EA exhibits many biological properties such as antioxidant, anti-diabetic, anticancer and apoptosis-inducing activities. These biological and pharmacological properties are relevant to the treatment of several human diseases. Conclusion: Owing to its multiple mechanisms of action, EA represents a potential therapeutic agent against human diseases particularly cancer.

scholarly journals SIRT2 Protein Expression in Normal and Aged Rat Brain

2012 ◽  
Vol 16 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Chang Seok Oh M.S. ◽  
Eunju Lee M.D. ◽  
Young Soo Lee M.D.
Keyword(s):  
Protein Expression ◽  
Rat Brain ◽  
Aged Rat
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