Prevalence and Association of Perianal and Intra-Anal Warts with Composite High-Grade Squamous Intraepithelial Lesions Among Gay and Bisexual Men: Baseline Data from the Study of the Prevention of Anal Cancer

2020 ◽  
Vol 34 (10) ◽  
pp. 436-443
Author(s):  
Sian L. Goddard ◽  
David J. Templeton ◽  
Kathy Petoumenos ◽  
Fengyi Jin ◽  
Richard J. Hillman ◽  
...  
Keyword(s):  
Anal Cancer ◽  
Gay And Bisexual Men ◽  
Baseline Data ◽  
High Grade ◽  
Bisexual Men ◽  
Squamous Intraepithelial Lesions ◽  
Anal Warts ◽  
And Bisexual ◽  
Intraepithelial Lesions

The performance of human papillomavirus biomarkers in predicting anal high-grade squamous intraepithelial lesions in gay and bisexual men

AIDS ◽  
2017 ◽  
Vol 31 (9) ◽  
pp. 1303-1311 ◽  
Author(s):  
Fengyi Jin ◽  
Jennifer M. Roberts ◽  
Andrew E. Grulich ◽  
Isobel M. Poynten ◽  
Dorothy A. Machalek ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Gay And Bisexual Men ◽  
High Grade ◽  
Bisexual Men ◽  
Squamous Intraepithelial Lesions ◽  
And Bisexual ◽  
Intraepithelial Lesions

The Natural History of Anal High-grade Squamous Intraepithelial Lesions in Gay and Bisexual Men

2020 ◽  
Author(s):  
I Mary Poynten ◽  
Fengyi Jin ◽  
Jennifer M Roberts ◽  
David J Templeton ◽  
Carmella Law ◽  
...  
Keyword(s):  
Natural History ◽  
Gay And Bisexual Men ◽  
Hiv Positive ◽  
High Grade ◽  
Bisexual Men ◽  
Squamous Intraepithelial Lesions ◽  
History Of ◽  
And Bisexual ◽  
Intraepithelial Lesions

Abstract Background Gay and bisexual men (GBM) are disproportionately affected by anal cancer. Prevention is hindered by incomplete understanding of the natural history of its precursor, anal high-grade squamous intraepithelial lesions (HSIL). Methods The Study of the Prevention of Anal Cancer, conducted between 2010 and 2018, enrolled human immunodeficiency virus (HIV)-positive and HIV-negative GBM aged ≥35 years. Anal cytology and high-resolution anoscopy (HRA) were performed at baseline and 3 annual visits. A composite HSIL diagnosis (cytology ± histology) was used. Cytological high-grade squamous intraepithelial lesions (cHSIL) incidence and clearance rates were calculated with 95% confidence intervals (CIs). Predictors were calculated using Cox regression with hazard ratios (HRs) and 95% CIs. Results Among 617 men, 220 (35.7%) were HIV-positive, median age 49 years. And 124 incident cHSIL cases occurred over 1097.3 person-years (PY) follow-up (11.3, 95% CI 9.5–13.5 per 100 PY). Significant bivariate predictors of higher incidence included age <45 years (HR 1.64, 95% CI 1.11–2.41), HIV positivity (HR 1.43, 95% CI .99–2.06), prior SIL diagnosis (P-trend < .001) and human papillomavirus (HPV)16 (HR 3.39, 2.38–4.84). Over 695.3 PY follow-up, 153 HSIL cleared (clearance 22.0, 95% CI 18.8–25.8 per 100 PY). Predictors were age < 45 years (HR 1.52, 1.08–2.16), anal intraepithelial neoplasia (AIN)2 rather than AIN3 (HR 1.79, 1.29–2.49), smaller lesions (HR 1.62, 1.11–2.36) and no persistent HPV16 (HR 1.72, 1.23–2.41). There was 1 progression to cancer (incidence 0.224, 95% CI .006–1.25 per 100 PY). Conclusion These data strongly suggest that not all anal HSIL detected in screening requires treatment. Men with persistent HPV16 were less likely to clear HSIL and are more likely to benefit from effective HSIL treatments.

scholarly journals Anal Cancer Prevention Perspectives Among Foreign-Born Latino HIV-Infected Gay and Bisexual Men

2018 ◽  
Vol 25 (1) ◽  
pp. 107327481878036 ◽  
Author(s):  
Alexis M. Koskan ◽  
Madeline Fernandez-Pineda
Keyword(s):  
Cancer Screening ◽  
Secondary Prevention ◽  
Anal Cancer ◽  
Pap Smear ◽  
Gay And Bisexual Men ◽  
Bisexual Men ◽  
Foreign Born ◽  
Primary And Secondary Prevention ◽  
And Bisexual ◽  
Anal Cancer Screening

This study explores understanding of primary and secondary prevention of anal cancer among human immunodeficiency virus (HIV)-infected foreign-born Latino gay and bisexual men (GBM). Between August 2015 and December 2016, researchers conducted 33 in-depth, semi-structured interviews with HIV-infected foreign-born Latino GBM. Interview questions sought to determine participants’ knowledge and perceived barriers and facilitators to primary and secondary prevention of anal cancer. Researchers analyzed interview transcripts using a qualitative content analysis approach. For primary prevention, men reported a lack of knowledge about the human papillomavirus (HPV) vaccine. However, for secondary prevention, roughly 60% of participants had previously screened for anal dysplasia via anal Papanicolaou (Pap) smear. However, participants reported willingness to screen, and provider recommendation was the most common screening facilitator. Men reported stigma related to their HIV status, sexual orientation, and anal Pap smear procedures as anal cancer screening barriers. Participants reported willingness to use a self-screening anal Pap smear test if it was commercially available. Health providers continue to be the leading source of health information. Therefore, provider recommendation for HPV vaccination and anal cancer screening among age-eligible foreign-born Latino HIV-infected GBM is critical. More work is needed to destigmatize HIV and sexual orientation to influence positive health behaviors among this population. Future intervention research could test the effects of provider-led interventions and also media campaigns aimed at influencing HPV vaccine uptake and anal cancer screening among this population.

scholarly journals Progression of anal high‐grade squamous intraepithelial lesions to invasive anal cancer among HIV‐infected men who have sex with men

2013 ◽  
Vol 134 (5) ◽  
pp. 1147-1155 ◽  
Author(s):  
J. Michael Berry ◽  
Naomi Jay ◽  
Ross D. Cranston ◽  
Teresa M. Darragh ◽  
Elizabeth A. Holly ◽  
...  
Keyword(s):  
Anal Cancer ◽  
High Grade ◽  
Squamous Intraepithelial Lesions ◽  
Sex With Men ◽  
Intraepithelial Lesions
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