The Relationship of Post-traumatic Stress Disorder and Depression to Antiretroviral Medication Adherence in Persons with HIV

2008 ◽  
Vol 22 (4) ◽  
pp. 313-321 ◽  
Author(s):  
Ana Maria Vranceanu ◽  
Steven A. Safren ◽  
Minyi Lu ◽  
William M. Coady ◽  
Paul R. Skolnik ◽  
...  
Keyword(s):  
Medication Adherence ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Antiretroviral Medication ◽  
Antiretroviral Medication Adherence ◽  
Post Traumatic ◽  
Relationship Of ◽  
The Relationship

Neuroticism and post-traumatic stress disorder: a prospective investigation

2012 ◽  
Vol 43 (8) ◽  
pp. 1697-1702 ◽  
Author(s):  
N. Breslau ◽  
L. Schultz
Keyword(s):  
Young Adults ◽  
Major Depression ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
History Of ◽  
Post Traumatic ◽  
Relationship Of ◽  
The Relationship

BackgroundNeuroticism has been consistently correlated with the post-traumatic stress disorder (PTSD) response to traumatic events. Interpretation of these findings is limited by the retrospective nature of these findings: neuroticism was measured after the trauma had occurred. The prospective association of neuroticism with PTSD has not been examined (the relationship of neuroticism with PTSD symptoms was examined in a few prospective studies). We evaluate prospectively the relationship of neuroticism, measured at baseline, with the cumulative occurrence of PTSD during the subsequent 10 years, using data from a longitudinal epidemiological study of young adults.MethodA sample of 1007 young adults randomly selected from the membership of a large health maintenance organization in southeast Michigan was assessed at baseline and followed up at 3, 5 and 10 years later. We conducted a series of multinomial logistic regressions to estimate the relative risk (RR) of exposure to trauma and PTSD by neuroticism at baseline, adjusting for history of major depression (n = 990).ResultsDuring the 10-year follow-up, 50.2% of the sample experienced traumatic events and 5.2% developed PTSD. Neuroticism score at baseline increased significantly the RR of PTSD response to trauma. Additional analysis revealed that, among persons with history of major depression at baseline, RR for PTSD associated with neuroticism was equal to the null value of 1, but was increased significantly among those with no history of major depression.ConclusionsThe results confirm the role of neuroticism as diathesis in the PTSD response to traumatic experiences.

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