Chemokine Coreceptor Usage Among HIV-1 Drug-Naive Patients Residing in the Rural Eastern Cape, South Africa

2020 ◽  
Vol 36 (8) ◽  
pp. 688-696
Author(s):  
Tennison Onoriode Digban ◽  
Benson Chucks Iweriebor ◽  
Uchechukwu U. Nwodo ◽  
Anthony Ifeanyi Okoh ◽  
Larry Chikwelu Obi
Keyword(s):  
South Africa ◽  
Coreceptor Usage ◽  
Eastern Cape ◽  
Drug Naïve ◽  
Hiv 1

HIV-1 drug resistance surveillance among parturient women on anti-retroviral therapy in the Eastern Cape, South Africa: Implications for elimination of mother-to-child transmission

2019 ◽  
Vol 117 ◽  
pp. 89-95 ◽  
Author(s):  
Oladele Vincent Adeniyi ◽  
Chikwelu Larry Obi ◽  
Daniel Ter Goon ◽  
Benson Iweriebor ◽  
Anthony Idowu Ajayi ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Eastern Cape ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Mother To Child ◽  
Hiv 1

scholarly journals Coreceptor Usage, Diversity, and Divergence in Drug-Naive and Drug-Exposed Individuals from Malawi, Infected with HIV-1 Subtype C for More Than 20 Years

2014 ◽  
Vol 30 (10) ◽  
pp. 975-983 ◽  
Author(s):  
Ishla Seager ◽  
Simon A. Travers ◽  
Michael D. Leeson ◽  
Amelia C. Crampin ◽  
Neil French ◽  
...  
Keyword(s):  
Coreceptor Usage ◽  
Subtype C ◽  
Drug Naïve ◽  
Hiv 1

Molecular Genetics and the Incidence of Transmitted Drug Resistance Among Pre-Treatment HIV-1 Infected Patients in the Eastern Cape, South Africa

2019 ◽  
Vol 17 (5) ◽  
pp. 335-342
Author(s):  
Tennison Onoriode Digban ◽  
Benson Chucks Iweriebor ◽  
Larry Chikwelu Obi ◽  
Uchechuwku Nwodo ◽  
Anthony Ifeanyi Okoh
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Transmitted Drug Resistance ◽  
Eastern Cape ◽  
Resistance Mutations ◽  
Subtype C ◽  
Drug Resistance Mutations ◽  
Combined Antiretroviral Therapy ◽  
Pre Treatment ◽  
Hiv 1

Background: Transmitted drug resistance (TDR) remains a significant threat to Human immunodeficiency virus (HIV) infected patients that are not exposed to antiretroviral treatment. Although, combined antiretroviral therapy (cART) has reduced deaths among infected individuals, emergence of drug resistance is gradually on rise. Objective: To determine the drug resistance mutations and subtypes of HIV-1 among pre-treatment patients in the Eastern Cape of South Africa. Methods: Viral RNA was extracted from blood samples of 70 pre-treatment HIV-1 patients while partial pol gene fragment amplification was achieved with specific primers by RT-PCR followed by nested PCR and positive amplicons were sequenced utilizing ABI Prism 316 genetic sequencer. Drug resistance mutations (DRMs) analysis was performed by submitting the generated sequences to Stanford HIV drug resistance database. Results: Viral DNA was successful for 66 (94.3%) samples of which 52 edited sequences were obtained from the protease and 44 reverse transcriptase sequences were also fully edited. Four major protease inhibitor (PI) related mutations (I54V, V82A/L, L76V and L90M) were observed in seven patients while several other minor and accessory PIs were also identified. A total of 11(25.0%) patients had NRTIs related mutations while NNRTIs were observed among 14(31.8%) patients. K103N/S, V106M and M184V were the most common mutations identified among the viral sequences. Phylogenetic analysis of the partial pol gene indicated all sequences clustered with subtype C. Conclusions: This study indicates that HIV-1 subtype C still predominates and responsible for driving the epidemic in the Eastern Cape of South Africa with slow rise in the occurrence of transmitted drug resistance.

HIV-1 Subtype C Reverse Transcriptase Sequences from Drug-Naive Pregnant Women in South Africa

2002 ◽  
Vol 18 (8) ◽  
pp. 605-610 ◽  
Author(s):  
Candice Pillay ◽  
Helba Bredell ◽  
James McIntyre ◽  
Glenda Gray ◽  
Lynn Morris
Keyword(s):  
South Africa ◽  
Reverse Transcriptase ◽  
Pregnant Women ◽  
Subtype C ◽  
Drug Naïve ◽  
Hiv 1

Genetic Characterization of HIV-1 Subtype A1/C/D/B/K Unique Recombinant Form from Eastern Cape, South Africa

2020 ◽  
Author(s):  
Oladele Vincent Adeniyi ◽  
Chikwelu Larry Obi ◽  
Daniel Ter Goon ◽  
Benson Iweriebor ◽  
Wezile Chitha ◽  
...  
Keyword(s):  
South Africa ◽  
Genetic Characterization ◽  
Recombinant Form ◽  
Eastern Cape ◽  
Unique Recombinant Form ◽  
Hiv 1

Analyses of HIV‐1 integrase gene sequences among treatment‐naive patients in the Eastern Cape, South Africa

2020 ◽  
Vol 92 (8) ◽  
pp. 1165-1172
Author(s):  
Tennison Onoriode Digban ◽  
Benson Chucks Iweriebor ◽  
Larry Chikwelu Obi ◽  
Uchechuwku Nwodo ◽  
Anthony Ifeanyi Okoh
Keyword(s):  
South Africa ◽  
Eastern Cape ◽  
Gene Sequences ◽  
Integrase Gene ◽  
Treatment Naïve ◽  
Hiv 1

scholarly journals The PTAP sequence duplication in HIV-1 subtype C Gag p6 in drug-naive subjects of India and South Africa

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Shilpee Sharma ◽  
Shambhu G. Aralaguppe ◽  
Melissa-Rose Abrahams ◽  
Carolyn Williamson ◽  
Clive Gray ◽  
...  
Keyword(s):  
South Africa ◽  
Subtype C ◽  
Drug Naïve ◽  
Hiv 1
Sign in / Sign up

Export Citation Format

Share Document