scholarly journals Short Communication: Early Antiretroviral Therapy Is Associated with Better Viral Suppression and Less HIV Drug Resistance After Implementation of Universal Treatment in South Africa

2020 ◽  
Vol 36 (4) ◽  
pp. 297-299
Author(s):  
Jienchi Dorward ◽  
Paul K. Drain ◽  
Farzana Osman ◽  
Yukteshwar Sookrajh ◽  
Melendhran Pillay ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Viral Suppression ◽  
Short Communication ◽  
Hiv Drug Resistance ◽  
Universal Treatment

scholarly journals HIV drug resistance levels in adults failing first-line antiretroviral therapy in an urban and a rural setting in South Africa

HIV Medicine ◽  
2016 ◽  
Vol 18 (2) ◽  
pp. 104-114 ◽  
Author(s):  
TM Rossouw ◽  
M Nieuwoudt ◽  
J Manasa ◽  
G Malherbe ◽  
RJ Lessells ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Rural Setting ◽  
First Line ◽  
Hiv Drug Resistance

scholarly journals HIV Drug Resistance Mutations Detection by Next-Generation Sequencing during Antiretroviral Therapy Interruption in China

Pathogens ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 264
Author(s):  
Miaomiao Li ◽  
Shujia Liang ◽  
Chao Zhou ◽  
Min Chen ◽  
Shu Liang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Next Generation Sequencing ◽  
Antiretroviral Therapy ◽  
Detection Threshold ◽  
Next Generation ◽  
Resistance Mutations ◽  
Hiv Drug Resistance ◽  
Drug Resistance Mutations ◽  
Therapy Interruption ◽  
Generation Sequencing

Patients with antiretroviral therapy interruption have a high risk of virological failure when re-initiating antiretroviral therapy (ART), especially those with HIV drug resistance. Next-generation sequencing may provide close scrutiny on their minority drug resistance variant. A cross-sectional study was conducted in patients with ART interruption in five regions in China in 2016. Through Sanger and next-generation sequencing in parallel, HIV drug resistance was genotyped on their plasma samples. Rates of HIV drug resistance were compared by the McNemar tests. In total, 174 patients were included in this study, with a median 12 (interquartile range (IQR), 6–24) months of ART interruption. Most (86.2%) of them had received efavirenz (EFV)/nevirapine (NVP)-based first-line therapy for a median 16 (IQR, 7–26) months before ART interruption. Sixty-one (35.1%) patients had CRF07_BC HIV-1 strains, 58 (33.3%) CRF08_BC and 35 (20.1%) CRF01_AE. Thirty-four (19.5%) of the 174 patients were detected to harbor HIV drug-resistant variants on Sanger sequencing. Thirty-six (20.7%), 37 (21.3%), 42 (24.1%), 79 (45.4%) and 139 (79.9) patients were identified to have HIV drug resistance by next-generation sequencing at 20% (v.s. Sanger, p = 0.317), 10% (v.s. Sanger, p = 0.180), 5% (v.s. Sanger, p = 0.011), 2% (v.s. Sanger, p < 0.001) and 1% (v.s. Sanger, p < 0.001) of detection thresholds, respectively. K65R was the most common minority mutation, of 95.1% (58/61) and 93.1% (54/58) in CRF07_BC and CRF08_BC, respectively, when compared with 5.7% (2/35) in CRF01_AE (p < 0.001). In 49 patients that followed-up a median 10 months later, HIV drug resistance mutations at >20% frequency such as K103N, M184VI and P225H still existed, but with decreased frequencies. The prevalence of HIV drug resistance in ART interruption was higher than 15% in the survey. Next-generation sequencing was able to detect more minority drug resistance variants than Sanger. There was a sharp increase in minority drug resistance variants when the detection threshold was below 5%.

scholarly journals HIV drug resistance and antiretroviral therapy programs in Henan, China-authors’ reply

2020 ◽  
Vol 19 ◽  
pp. 100272
Author(s):  
Lulu Zuo ◽  
Jianru Qin ◽  
Qinggang Xu ◽  
Chiyu Zhang
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Hiv Drug Resistance

Evaluation of Acquired HIV Drug Resistance among People Living with HIV Who Have Taken Antiretroviral Therapy for 9–15 Months in 14 Triangular Clinics in Iran, 2015–2016

Intervirology ◽  
2018 ◽  
Vol 61 (6) ◽  
pp. 292-300 ◽  
Author(s):  
Minoo Mohraz ◽  
Katayoun Tayeri ◽  
Hengameh Namdari Tabar ◽  
Zahra Bayat Jozani ◽  
Leila Sadeghi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
People Living With Hiv ◽  
Hiv Drug Resistance ◽  
Living With Hiv

scholarly journals Patient-Initiated Repackaging of Antiretroviral Therapy, Viral Suppression and Drug Resistance

2017 ◽  
Vol 22 (5) ◽  
pp. 1671-1678
Author(s):  
Habib O. Ramadhani ◽  
Charles Muiruri ◽  
Venance P. Maro ◽  
Balthazar Nyombi ◽  
Michael Omondi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Viral Suppression

scholarly journals HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected Patients

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e54917 ◽  
Author(s):  
Hui Xing ◽  
Yuhua Ruan ◽  
Jingyun Li ◽  
Hong Shang ◽  
Ping Zhong ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Hiv Drug Resistance
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