scholarly journals Short Communication: Viral Genetic Linkage Analysis Among Black Men Who Have Sex With Men (HIV Prevention Trials Network 061)

2019 ◽  
Vol 35 (5) ◽  
pp. 434-436
Author(s):  
Julia Kobe ◽  
Octavious Talbot ◽  
Iris Chen ◽  
Susan H. Eshleman ◽  
Vanessa Cummings ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Linkage Analysis ◽  
Black Men ◽  
Genetic Linkage ◽  
Short Communication ◽  
Genetic Linkage Analysis ◽  
Prevention Trials ◽  
Sex With Men

scholarly journals Development of a Black Caucus within the HIV Prevention Trials Network (HPTN): Representing the Perspectives of Black Men Who Have Sex with Men (MSM)

2020 ◽  
Vol 17 (3) ◽  
pp. 871 ◽  
Author(s):  
Christopher Watson ◽  
Leo Wilton ◽  
Jonathan Lucas ◽  
Lawrence Bryant ◽  
Gregory Victorianne ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Hiv Prevention ◽  
Black Men ◽  
The United States ◽  
Black Msm ◽  
Black Caucus ◽  
Prevention Trials ◽  
Hiv Clinical Trials ◽  
Sex With Men

Black men who have sex with men (MSM) have disproportionate HIV disease burden in the United States. Black MSM have been underrepresented in biomedical research, including HIV clinical trials, due to a myriad of socio-structural, socio-cultural, and psychosocial factors. The HIV Prevention Trials Network (HPTN) 061, a feasibility study of a multi-component HIV prevention intervention for Black MSM in six US cities, incorporated the development and implementation of a Black Caucus as a culturally grounded model for the integration of Black MSM in clinical trials and research in HPTN. Based on a qualitative methodological approach, we describe the formation and implementation of the Black Caucus from the perspective of Black MSM key community stakeholders. Three major themes emerged from the qualitative narratives: (1) the role of the Black Caucus in shaping the HPTN, (2) how the Black Caucus addresses the needs of Black MSM communities pertaining to the influence of race and sexual identity, and (3) socio-cultural needs of Black MSM. These findings have implications for the provision of culturally congruent expertise, community engagement, cultural mistrust, recruitment and retention of Black MSM in HIV clinical trials, culturally-relevant study design and implementation, and the role of developing Black MSM prevention researchers.

scholarly journals Sexual Risk Behaviors Among Black Men Who Have Sex With Men Who Also Report Having Sex With Transgender Partners: Analysis of HIV Prevention Trials Network (HPTN) 061 Study

2017 ◽  
Vol 29 (5) ◽  
pp. 418-431 ◽  
Author(s):  
Grace (Chela) Hall ◽  
Alicia Young ◽  
Chloe Krakauer ◽  
Christopher Chauncey Watson ◽  
Vanessa Cummings ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Sexual Risk ◽  
Black Men ◽  
Risk Behaviors ◽  
Sexual Risk Behaviors ◽  
Prevention Trials ◽  
Sex With Men

scholarly journals Incidence and Correlates of Sexually Transmitted Infections Among Black Men Who Have Sex With Men Participating in the HIV Prevention Trials Network 073 Preexposure Prophylaxis Study

2019 ◽  
Vol 69 (9) ◽  
pp. 1597-1604 ◽  
Author(s):  
Lisa B Hightow-Weidman ◽  
Manya Magnus ◽  
Geetha Beauchamp ◽  
Christopher B Hurt ◽  
Steve Shoptaw ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Sexually Transmitted Infections ◽  
Black Men ◽  
Sexual Behaviors ◽  
Nucleic Acid Amplification ◽  
Sexually Transmitted ◽  
Preexposure Prophylaxis ◽  
Centered Care ◽  
Prevention Trials ◽  
Sex With Men

Abstract Background The HIV Prevention Trials Network (HPTN) Study 073 (HPTN 073) assessed the feasibility, acceptability, and safety of preexposure prophylaxis (PrEP) for black men who have sex with men (BMSM). The purpose of this analysis was to characterize the relationship between PrEP uptake and use and incident sexually transmitted infections (STIs) among participants enrolled in HPTN 073. Methods A total of 226 human immunodeficiency virus (HIV)–uninfected BMSM were enrolled in 3 US cities; all participants received client-centered care coordination (C4) and were offered daily oral PrEP. Participants were followed for 12 months with STI testing (rectal and urine nucleic acid amplification test for gonorrhea and chlamydia, rapid plasma reagin for syphilis) conducted at baseline, week 26, and week 52. Logistic regression was used to examine associations between STI incidence and PrEP uptake. Generalized estimating equations were used to evaluate associations between age, PrEP acceptance, sexual behaviors, and incident STIs. Results Baseline STI prevalence was 14.2%. Men aged <25 years were more likely to have a baseline STI (25.3% vs 6.7%; odds ratio [OR], 4.39; 95% confidence interval [CI:, 1.91, 10.11). Sixty participants (26.5%) acquired ≥1 STI during follow-up; the incidence rate was 34.2 cases per 100 person-years (95% CI, 27.4, 42.9). In adjusted analyses, baseline STI diagnosis (OR, 4.23; 95% CI, 1.82, 9.87; P < .001) and additional C4 time (OR, 1.03; 95% CI, 1.00, 1.06; P = .027) were associated with having an incident STI. STI incidence was not associated with PrEP acceptance or adherence. Conclusions While we found higher rates of STIs in younger BMSM, overall rates of STI were lower than in prior PrEP trials, with no increase over time. BMSM with STIs at PrEP initiation may require additional interventions that target STI acquisition risk. Clinical Trials Registration NCT01808352.

scholarly journals CXCR4-using HIV variants in a cohort of Black men who have sex with men: HIV Prevention Trials Network 061

2016 ◽  
Vol 17 (4) ◽  
pp. 158-164 ◽  
Author(s):  
Iris Chen ◽  
Wei Huang ◽  
Matthew B. Connor ◽  
Arne Frantzell ◽  
Vanessa Cummings ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Black Men ◽  
Prevention Trials ◽  
Sex With Men

scholarly journals Correlates of HIV Acquisition in a Cohort of Black Men Who Have Sex with Men in the United States: HIV Prevention Trials Network (HPTN) 061

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e70413 ◽  
Author(s):  
Beryl A. Koblin ◽  
Kenneth H. Mayer ◽  
Susan H. Eshleman ◽  
Lei Wang ◽  
Sharon Mannheimer ◽  
...  
Keyword(s):  
United States ◽  
Hiv Prevention ◽  
Black Men ◽  
The United States ◽  
Prevention Trials ◽  
Sex With Men ◽  
Hiv Acquisition

Genetic Linkage Analysis of the Carpal Tunnel Syndrome

1985 ◽  
Vol 35 (5) ◽  
pp. 288-291 ◽  
Author(s):  
R.S. Sparkes ◽  
M.A. Spence ◽  
N.L. Gottlieb ◽  
R.G. Gray ◽  
M. Crist ◽  
...  
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Linkage Analysis ◽  
Carpal Tunnel ◽  
Genetic Linkage ◽  
Genetic Linkage Analysis ◽  
Tunnel Syndrome

scholarly journals The sumLINK statistic for genetic linkage analysis in the presence of heterogeneity

2009 ◽  
Vol 33 (7) ◽  
pp. 628-636 ◽  
Author(s):  
G. B. Christensen ◽  
S. Knight ◽  
N. J. Camp
Keyword(s):  
Linkage Analysis ◽  
Genetic Linkage ◽  
Genetic Linkage Analysis

scholarly journals 295 GENETIC LINKAGE ANALYSIS AND META ANALYSIS OF STIMULATED CYTOKINE LEVELS IN DUTCH FAMILY BASED STUDIES

2007 ◽  
Vol 15 ◽  
pp. C164
Author(s):  
S.D. Bos ◽  
H. Putter ◽  
D. Posthuma ◽  
M. Kloppenburg ◽  
A. Seymour ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Genetic Linkage ◽  
Meta Analysis ◽  
Genetic Linkage Analysis ◽  
Cytokine Levels ◽  
Family Based ◽  
Dutch Family
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