CD4+ T Cell Recovery and Hepatitis B Virus Coinfection in HIV-Infected Patients from Côte d'Ivoire Initiating Antiretroviral Therapy

2018 ◽  
Vol 34 (5) ◽  
pp. 439-445
Author(s):  
Laura Houghtaling ◽  
Raoul Moh ◽  
Mariama Abdou Chekaraou ◽  
Delphine Gabillard ◽  
Xavier Anglaret ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Hepatitis B ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Cd4 T Cell ◽  
Cell Recovery ◽  
Cote D’Ivoire ◽  
B Virus

scholarly journals Hepatitis B Virus Prevalence and Vaccination in Men Who Have Sex With Men in West Africa (CohMSM ANRS 12324—Expertise France)

2019 ◽  
Vol 6 (7) ◽  
Author(s):  
Ter Tiero Elias Dah ◽  
Clotilde Couderc ◽  
Alou Coulibaly ◽  
Malan Jean-Baptiste kouamé ◽  
Mawuényégan Kouamivi Agboyibor ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
West Africa ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Hbv Infection ◽  
Cote D’Ivoire ◽  
B Virus ◽  
Hbv Prevalence ◽  
Sex With Men

AbstractBackgroundAlthough men who have sex with men (MSM) are at high risk of hepatitis B virus (HBV) infection, they do not have access to vaccination in West Africa, which is a highly endemic region. We investigated HBV prevalence and associated factors, as well as acceptability and difficulties of vaccination in MSM enrolled in an operational research program in Burkina Faso, Côte d’Ivoire, Mali, and Togo.MethodsWe followed up 779 MSM in 2015–2018. Participants who were negative for both hepatitis B surface antigen (HBsAg) and antibodies (anti-HBs) at enrollment were offered HBV vaccination. Factors associated with HBV infection were identified using logistic regression models.ResultsOverall, HBV prevalence was 11.2% (95% confidence interval [CI], 9.0%–13.6%). It was lower in Togo than in Côte d’Ivoire (2.7% vs 17.3%; adjusted odds ratio [aOR], 0.12; 95% CI, 0.02–0.28) and higher in participants with 6+ recent male sexual partners (21.0% vs 9.3%; aOR, 1.48; 95% CI, 1.12–1.97). Of 528 participants eligible for vaccination, 484 (91.7%) were willing to be vaccinated and received at least 1 dose (ranging from 68.2% in Abidjan to 96.4% in Bamako; P < .001). Of the latter, 390 (80.6%) received 3 or 4 doses. The proportion of participants for whom the minimum required time between each dose was respected ranged from 10.9% in Bamako to 88.6% in Lomé (P < .001).ConclusionsMSM in West Africa should be targeted more for HBV screening and vaccination. Although vaccination is well accepted by MSM, greater training of health care workers and education of MSM are required.

scholarly journals The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection

2009 ◽  
Vol 83 (19) ◽  
pp. 9652-9662 ◽  
Author(s):  
Shinichi Asabe ◽  
Stefan F. Wieland ◽  
Pratip K. Chattopadhyay ◽  
Mario Roederer ◽  
Ronald E. Engle ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Viral Spread ◽  
B Virus ◽  
T Cell Priming ◽  
Kinetics Of

ABSTRACT The impact of virus dose on the outcome of infection is poorly understood. In this study we show that, for hepatitis B virus (HBV), the size of the inoculum contributes to the kinetics of viral spread and immunological priming, which then determine the outcome of infection. Adult chimpanzees were infected with a serially diluted monoclonal HBV inoculum. Unexpectedly, despite vastly different viral kinetics, both high-dose inocula (1010 genome equivalents [GE] per animal) and low-dose inocula (10° GE per animal) primed the CD4 T-cell response after logarithmic spread was detectable, allowing infection of 100% of hepatocytes and requiring prolonged immunopathology before clearance occurred. In contrast, intermediate (107 and 104 GE) inocula primed the T-cell response before detectable logarithmic spread and were abruptly terminated with minimal immunopathology before 0.1% of hepatocytes were infected. Surprisingly, a dosage of 101 GE primed the T-cell response after all hepatocytes were infected and caused either prolonged or persistent infection with severe immunopathology. Finally, CD4 T-cell depletion before inoculation of a normally rapidly controlled inoculum precluded T-cell priming and caused persistent infection with minimal immunopathology. These results suggest that the relationship between the kinetics of viral spread and CD4 T-cell priming determines the outcome of HBV infection.

scholarly journals Effect of HIV Infection and Antiretroviral Therapy on Hepatitis B Virus (HBV)–Specific T Cell Responses in Patients Who Have Resolved HBV Infection

2005 ◽  
Vol 191 (7) ◽  
pp. 1169-1179 ◽  
Author(s):  
R. Monica Lascar ◽  
A. Ross Lopes ◽  
Richard J. Gilson ◽  
Claire Dunn ◽  
Ruth Johnstone ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Hepatitis B ◽  
Hiv Infection ◽  
T Cell Responses ◽  
Hbv Infection ◽  
Cell Responses ◽  
B Virus

scholarly journals Hepatitis B virus-specific CD4 T cell immunity after liver transplantation for chronic hepatitis B

2009 ◽  
Vol 15 (3) ◽  
pp. 292-299 ◽  
Author(s):  
Ying Luo ◽  
Chung Mau Lo ◽  
Cindy K. Cheung ◽  
George K. Lau ◽  
John Wong
Keyword(s):  
Liver Transplantation ◽  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
T Cell Immunity ◽  
Cd4 T Cell ◽  
Cell Immunity ◽  
B Virus

scholarly journals Hepatitis B virus (HBV)-derived DRB1*0101-restricted CD4 T-cell epitopes help in the development of HBV-specific CD8+ T cells in vivo

Vaccine ◽  
2010 ◽  
Vol 28 (22) ◽  
pp. 3818-3826 ◽  
Author(s):  
Florence Bayard ◽  
Silvina Malmassari ◽  
Qiang Deng ◽  
Yu-Chun Lone ◽  
Marie-Louise Michel
Keyword(s):  
T Cells ◽  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Cd8 T Cells ◽  
Cd4 T Cell ◽  
T Cell Epitopes ◽  
B Virus
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