scholarly journals Increasing HIV-1 Drug Resistance Between 2010 and 2012 in Adults Participating in Population-Based HIV Surveillance in Rural KwaZulu-Natal, South Africa

2016 ◽  
Vol 32 (8) ◽  
pp. 763-769 ◽  
Author(s):  
Justen Manasa ◽  
Siva Danaviah ◽  
Richard Lessells ◽  
Muna Elshareef ◽  
Frank Tanser ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Population Based ◽  
Hiv Surveillance ◽  
Kwazulu Natal ◽  
Hiv 1

scholarly journals Rates of virological suppression and drug resistance in adult HIV-1-positive patients attending primary healthcare facilities in KwaZulu-Natal, South Africa

2017 ◽  
Vol 72 (11) ◽  
pp. 3141-3148 ◽  
Author(s):  
Gillian M Hunt ◽  
E. Kainne Dokubo ◽  
Simbarashe Takuva ◽  
Tulio de Oliveira ◽  
Johanna Ledwaba ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Primary Healthcare ◽  
Virological Suppression ◽  
Healthcare Facilities ◽  
Kwazulu Natal ◽  
Hiv 1

scholarly journals Rates of virological suppression and drug resistance in adult HIV-1-positive patients attending primary healthcare facilities in KwaZulu-Natal, South Africa

2017 ◽  
Vol 72 (11) ◽  
pp. 3222-3222
Author(s):  
Gillian M Hunt ◽  
E Kainne Dokubo ◽  
Simbarashe Takuva ◽  
Tulio de Oliveira ◽  
Johanna Ledwaba ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Primary Healthcare ◽  
Virological Suppression ◽  
Healthcare Facilities ◽  
Kwazulu Natal ◽  
Hiv 1

scholarly journals Prevalence of HIV-1 Drug Resistance among Women Screening for HIV Prevention Trials in KwaZulu-Natal, South Africa (MTN-009)

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e59787 ◽  
Author(s):  
Urvi M. Parikh ◽  
Photini Kiepiela ◽  
Shayhana Ganesh ◽  
Kailazarid Gomez ◽  
Stephanie Horn ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Hiv Prevention ◽  
Kwazulu Natal ◽  
Prevention Trials ◽  
Hiv 1

scholarly journals Prevalence of HIV‐1 Drug Resistance after Failure of a First Highly Active Antiretroviral Therapy Regimen in KwaZulu Natal, South Africa

2008 ◽  
Vol 46 (10) ◽  
pp. 1589-1597 ◽  
Author(s):  
Vincent C. Marconi ◽  
Henry Sunpath ◽  
Zhigang Lu ◽  
Michelle Gordon ◽  
Kofi Koranteng‐Apeagyei ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Therapy Regimen ◽  
Highly Active ◽  
Kwazulu Natal ◽  
Hiv 1

scholarly journals Drug Resistance and Viral Tropism in HIV-1 Subtype C-Infected Patients in KwaZulu-Natal, South Africa

2011 ◽  
Vol 58 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Ashika Singh ◽  
Henry Sunpath ◽  
Taryn N. Green ◽  
Nagavelli Padayachi ◽  
Keshni Hiramen ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Subtype C ◽  
Viral Tropism ◽  
Kwazulu Natal ◽  
Hiv 1

scholarly journals Correction: Prevalence of HIV-1 Drug Resistance among Women Screening for HIV Prevention Trials in KwaZulu-Natal, South Africa (MTN-009)

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
Author(s):  
Urvi M. Parikh ◽  
Photini Kiepiela ◽  
Shayhana Ganesh ◽  
Kailazarid Gomez ◽  
Stephanie Horn ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Hiv Prevention ◽  
Kwazulu Natal ◽  
Prevention Trials ◽  
Hiv 1

scholarly journals Acquired HIV drug resistance and virologic monitoring in a HIV hyper-endemic setting in KwaZulu-Natal Province, South Africa

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Benjamin Chimukangara ◽  
Richard J. Lessells ◽  
Lavanya Singh ◽  
Indra Grigalionyte ◽  
Nonhlanhla Yende-Zuma ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Sequence Data ◽  
Hiv Treatment ◽  
Close Monitoring ◽  
Second Line ◽  
First Line ◽  
Treatment Regimens ◽  
Kwazulu Natal ◽  
Hiv 1

Abstract Background Introduction of tenofovir (TDF) plus lamivudine (3TC) and dolutegravir (DTG) in first- and second-line HIV treatment regimens in South Africa warrants characterization of acquired HIV-1 drug resistance (ADR) mutations that could impact DTG-based antiretroviral therapy (ART). In this study, we sought to determine prevalence of ADR mutations and their potential impact on susceptibility to drugs used in combination with DTG among HIV-positive adults (≥ 18 years) accessing routine care at a selected ART facility in KwaZulu-Natal, South Africa. Methods We enrolled adult participants in a cross-sectional study between May and September 2019. Eligible participants had a most recent documented viral load (VL) ≥ 1000 copies/mL after at least 6 months on ART. We genotyped HIV-1 reverse transcriptase and protease genes by Sanger sequencing and assessed ADR. We characterized the effect of ADR mutations on the predicted susceptibility to drugs used in combination with DTG. Results From 143 participants enrolled, we obtained sequence data for 115 (80%), and 92.2% (95% CI 85.7–96.4) had ADR. The proportion with ADR was similar for participants on first-line ART (65/70, 92.9%, 95% CI 84.1–97.6) and those on second-line ART (40/44, 90.9%, 95% CI 78.3–97.5), and was present for the single participant on third-line ART. Approximately 89% (62/70) of those on first-line ART had dual class NRTI and NNRTI resistance and only six (13.6%) of those on second-line ART had major PI mutations. Most participants (82%) with first-line viraemia maintained susceptibility to Zidovudine (AZT), and the majority of them had lost susceptibility to TDF (71%) and 3TC (84%). Approximately two in every five TDF-treated individuals had thymidine analogue mutations (TAMs). Conclusions Susceptibility to AZT among most participants with first-line viraemia suggests that a new second-line regimen of AZT + 3TC + DTG could be effective. However, atypical occurrence of TAMs in TDF-treated individuals suggests a less effective AZT + 3TC + DTG regimen in a subpopulation of patients. As most patients with first-line viraemia had at least low-level resistance to TDF and 3TC, identifying viraemia before switch to TDF + 3TC + DTG is important to avoid DTG functional monotherapy. These findings highlight a need for close monitoring of outcomes on new standardized treatment regimens.

scholarly journals Surveillance of Transmitted HIV-1 Drug Resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005–2009

2012 ◽  
Vol 54 (suppl_4) ◽  
pp. S334-S338 ◽  
Author(s):  
G. M. Hunt ◽  
J. Ledwaba ◽  
A. E. Basson ◽  
J. Moyes ◽  
C. Cohen ◽  
...  
Keyword(s):  
South Africa ◽  
Drug Resistance ◽  
Kwazulu Natal ◽  
Hiv 1
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