HIV-1 Genetic Diversity and Transmitted Drug Resistance Among Recently Infected Individuals at Men Who Have Sex with Men Sentinel Surveillance Points in Hebei Province, China

2015 ◽  
Vol 31 (10) ◽  
pp. 1038-1045 ◽  
Author(s):  
Xinli Lu ◽  
Xianjiang Kang ◽  
Suliang Chen ◽  
Hongru Zhao ◽  
Yongjian Liu ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Sentinel Surveillance ◽  
Hebei Province ◽  
Transmitted Drug Resistance ◽  
Sex With Men ◽  
Hiv 1

HIV‐1 genetic diversity and transmitted drug resistance among newly diagnosed HIV‐1 individuals in Jiangmen, China

2020 ◽  
Vol 92 (12) ◽  
pp. 3209-3218
Author(s):  
Xin Guan ◽  
Min Han ◽  
Zhiju Li ◽  
Lihua Wang ◽  
Donghe Zhang ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Transmitted Drug Resistance ◽  
Newly Diagnosed ◽  
Hiv 1

HIV-1 genetic diversity and recombinant forms among men who have sex with men at a sentinel surveillance site in Xi'an City, China

2020 ◽  
Vol 81 ◽  
pp. 104257
Author(s):  
Wenhui Chang ◽  
Mengyan Zhang ◽  
Qiang Ren ◽  
Yangfan Zou ◽  
Lifang Dong ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Sentinel Surveillance ◽  
Surveillance Site ◽  
Sex With Men ◽  
Xi’An City ◽  
Hiv 1

Moderate prevalence of transmitted drug resistance and high HIV-1 genetic diversity in patients from Mato Grosso State, Central Western Brazil

2011 ◽  
Vol 83 (8) ◽  
pp. 1301-1307 ◽  
Author(s):  
Adriana Santarém Ferreira ◽  
Ludimila Paula Vaz Cardoso ◽  
Mariane Martins de Araújo Stefani
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Transmitted Drug Resistance ◽  
Mato Grosso ◽  
Hiv 1

HIV-1 transmitted drug resistance and genetic diversity among patients from Piauí State, Northeast Brazil

2015 ◽  
Vol 87 (5) ◽  
pp. 798-806 ◽  
Author(s):  
Maria Edileuza Soares Moura ◽  
Mônica Nogueira da Guarda Reis ◽  
Yanna Andressa Ramos Lima ◽  
Kelsen Dantas Eulálio ◽  
Ludimila Paula Vaz Cardoso ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Transmitted Drug Resistance ◽  
Northeast Brazil ◽  
Hiv 1

scholarly journals Sentinel Surveillance of HIV-1 Transmitted Drug Resistance, Acute Infection and Recent Infection

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e25281 ◽  
Author(s):  
Hong-Ha M. Truong ◽  
Timothy A. Kellogg ◽  
Willi McFarland ◽  
Brian Louie ◽  
Jeffrey D. Klausner ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Acute Infection ◽  
Sentinel Surveillance ◽  
Transmitted Drug Resistance ◽  
Recent Infection ◽  
Hiv 1

Alarming rate of transmitted drug resistance mutations and genetic diversity in newly HIV-1-infected patients in Benin

2020 ◽  
Author(s):  
Edmond Tchiakpe ◽  
Rene K Keke ◽  
Nicole Vidal ◽  
Clément Ahoussinou ◽  
Olga Sekpe ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Resistance Rate ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
High Genetic Diversity ◽  
Drug Resistance Mutations ◽  
Primary Drug Resistance ◽  
Hiv 1 ◽  
Primary Drug

Abstract BackgroundSeventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV naïve patients and HIV-1 genetic diversity were investigated in Benin.Methods353 plasma samples were collected between October and December 2017 in nineteen facilities care in Benin from HIV-1 positive and ARV naive individuals. Pol (protease + partial RT) region was amplified and sequenced in 248 samples.ResultsDrug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with predominance of mutations directed to NNRTIs drugs (24/248; 10%).Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV naïve patients.ConclusionsOur study showed a high primary drug resistance rate and a complex genetic diversity. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

scholarly journals Epidemiological and Molecular Characteristics of HIV-1 Infection in a Sample of Men Who Have Sex With Men in Brazil: Phylogeography of Major Subtype B and F1 Transmission Clusters

2020 ◽  
Vol 11 ◽  
Author(s):  
Ágabo Macêdo da Costa e Silva ◽  
Mônica Nogueira da Guarda Reis ◽  
Thaís Augusto Marinho ◽  
Nara Rúbia de Freitas ◽  
Sheila Araújo Teles ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Reverse Transcriptase ◽  
The State ◽  
Enzyme Linked Immunosorbent Assay ◽  
Molecular Characteristics ◽  
Resistance Mutations ◽  
Subtype B ◽  
Sex With Men ◽  
Hiv 1

This study describes human immunodeficiency virus 1 (HIV-1) prevalence, associated factors, viral genetic diversity, transmitted drug resistance (TDR), and acquired drug resistance mutations (DRM) among a population of 522 men who have sex with men (MSM) recruited by the respondent-driven sampling (RDS) method, in Goiânia city, the capital of the State of Goiás, Central-Western Brazil. All serum samples were tested using a four-generation enzyme-linked immunosorbent assay (ELISA), and reactive samples were confirmed by immunoblotting. Plasma RNA or proviral DNA was extracted, and partial polymerase (pol) gene including the protease/reverse transcriptase (PR/RT) region was amplified and sequenced. HIV-1 subtypes were identified by phylogenetic inference and by bootscan analysis. The time and location of the ancestral strains that originated the transmission clusters were estimated by a Bayesian phylogeographic approach. TDR and DRM were identified using the Stanford databases. Overall, HIV-1 prevalence was 17.6% (95% CI: 12.6–23.5). Self-declared black skin color, receptive anal intercourse, sex with drug user partner, and history of sexually transmitted infections were factors associated with HIV-1 infection. Of 105 HIV-1-positive samples, 78 (74.3%) were sequenced and subtyped as B (65.4%), F1 (20.5%), C (3.8%), and BF1 (10.3%). Most HIV-1 subtype B sequences (67%; 34 out of 51) branched within 12 monophyletic clusters of variable sizes, which probably arose in the State of Goiás between the 1980s and 2010s. Most subtype F1 sequences (n = 14, 88%) branched in a single monophyletic cluster that probably arose in Goiás around the late 1990s. Among 78 samples sequenced, three were from patients under antiretroviral therapy (ART); two presented DRM. Among 75 ART-naïve patients, TDR was identified in 13 (17.3%; CI 95%: 9.6–27.8). Resistance mutations to non-nucleoside reverse transcriptase inhibitors (NNRTI) predominated (14.7%), followed by nucleoside reverse transcriptase inhibitor (NRTI) mutations (5.3%) and protease inhibitor (PI) mutations (1.3%). This study shows a high prevalence of HIV-1 associated with sexual risk behaviors, high rate of TDR, and high genetic diversity driven by the local expansion of different subtype B and F1 strains. These findings can contribute to the understanding about the dissemination and epidemiological and molecular characteristics of HIV-1 among the population of MSM living away from the epicenter of epidemics in Brazil.

HIV-1 Genetic Diversity and Transmitted Drug Resistance Mutations in Female Sex Workers from a Brazilian Municipality in the Amazon Region

2020 ◽  
Vol 36 (2) ◽  
pp. 99-100 ◽  
Author(s):  
Luana Mota da Costa ◽  
Paula Cristina R. Frade ◽  
Lucinaldo da Silva Blandtt ◽  
Gláucia C. Silva-Oliveira ◽  
Luiz Fernando A. Machado ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Sex Workers ◽  
Female Sex Workers ◽  
Amazon Region ◽  
Transmitted Drug Resistance ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Female Sex ◽  
Hiv 1

scholarly journals Increase in HIV-1-transmitted drug resistance among ART-naïve youths at the China-Myanmar border during 2009 ~ 2017

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yibo Ding ◽  
Min Chen ◽  
Jibao Wang ◽  
Yuecheng Yang ◽  
Yi Feng ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Reverse Transcriptase ◽  
Cd4 Count ◽  
Transmitted Drug Resistance ◽  
Subtype C ◽  
Reverse Transcriptase Inhibitors ◽  
Recombination Hotspots ◽  
Subtype B ◽  
Sex With Men ◽  
Hiv 1

Abstract Background HIV-transmitted drug resistance (TDR) is found in antiretroviral therapy (ART)-naïve populations infected with HIV-1 with TDR mutations and is important for guiding future first- and second-line ART regimens. We investigated TDR and its effect on CD4 count in ART-naïve youths from the China-Myanmar border near the Golden Triangle to better understand TDR and effectively guide ART. Methods From 2009 to 2017, 10,832 HIV-1 infected individuals were newly reported along the Dehong border of China, 573 ART-naïve youths (16 ~ 25 y) were enrolled. CD4 counts were obtained from whole blood samples. HIV pol gene sequences were amplified from RNA extracted from plasma. The Stanford REGA program and jpHMM recombination prediction tool were used to determine genotypes. TDR mutations (TDRMs) were analyzed using the Stanford Calibrated Population Resistance tool. Results The most common infection route was heterosexuals (70.51%), followed by people who inject drugs (PWID, 19.20%) and men who have sex with men (MSM) (8.90%). The distribution of HIV genotypes mainly included the unique recombinant form (URF) (44.08%), 38.68% were CRFs, 13.24% were subtype C and 4.04% were subtype B. The prevalence of TDR increased significantly from 2009 to 2017 (3.48 to 9.48%) in ART-naïve youths (4.00 to 13.16% in Burmese subjects, 3.33 to 5.93% in Chinese subjects), and the resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs), nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs), and protease inhibitors (PIs) were 3.49, 2.62, and 0.52%, respectively. Most (94.40%, n = 34) of HIV-1-infected patients with TDRM had mutation that conferred resistance to a single drug class. The most common mutations Y181I/C and K103N, were found in 7 and 9 youths, respectively. The mean CD4 count was significantly lower among individuals with TDRMs (373/mm3 vs. 496/mm3, p = 0.013). Conclusions The increase in the prevalence of HIV-1 TDR increase and a low CD4 count of patients with TDRMs in the China-Myanmar border suggests the need for considering drug resistance before initiating ART in HIV recombination hotspots.

scholarly journals Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xianwu Pang ◽  
Hui Wei ◽  
Jinghua Huang ◽  
Qin He ◽  
Kailing Tang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
High Risk ◽  
Hiv Transmission ◽  
Transmitted Drug Resistance ◽  
Related Factors ◽  
Effective Strategies ◽  
Route Of Transmission ◽  
Sex With Men ◽  
Hiv 1

AbstractThe prevalence of HIV-1 in Guangxi is very high, and the rate of HIV-1 infection among men who have sex with men (MSM) has been increasing. Therefore, it is necessary to explore the patterns and risk factors of HIV transmission in Guangxi. For this purpose, individuals diagnosed with HIV-1 during 2013–2018 in Guangxi were recruited. Phylogenetic relationship, transmission clusters, and genotypic drug resistance analyses were performed based on HIV-1 pol sequences. Related factors were analysed to assess for their association with HIV-1 transmission. CRF07_BC (50.4%) and CRF01_AE (33.4%) were found to be the predominant subtypes. The analysed 1633 sequences (50.15%, Guangxi; 49.85%, other provinces) were segregated into 80 clusters (size per cluster, 2–704). We found that 75.3% of the individuals were in three clusters (size ˃ 100), and 73.8% were high-risk spreaders (links ≥ 4). Infection time, marital status, and subtype were significantly associated with HIV-1 transmission. Additionally, 80.2% of recent infections were linked to long-term infections, and 46.2% were linked to other provinces. A low level of transmitted drug resistance was detected (4.8%). Our findings indicated superclusters and high-risk HIV-1 spreaders among the MSM in Guangxi. Effective strategies blocking the route of transmission should be developed.

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