scholarly journals Inability to Detect Human T Cell Lymphotropic Virus Type 2-Specific Antibodies in a Patient Coinfected with HIV-1, Human T Cell Lymphotropic Virus Type 1, Human T Cell Lymphotropic Virus Type 2, and Hepatitis C Virus

2014 ◽  
Vol 30 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Adele Caterino-de-Araujo ◽  
Mariana Cavalheiro Magri ◽  
Neuza Satomi Sato ◽  
Helena Kaminami Morimoto ◽  
Luis Fernando de Macedo Brigido ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Virus Type ◽  
Specific Antibodies ◽  
Human T Cell ◽  
Hiv 1

scholarly journals Influence of human t-cell lymphotropic virus type 1 (HTLV-1) Infection on laboratory parameters of patients with chronic hepatitis C virus

2009 ◽  
Vol 51 (6) ◽  
pp. 325-329 ◽  
Author(s):  
Daniela Fernandes Cardoso ◽  
Fernando Vieira de Souza ◽  
Luiz Augusto M. Fonseca ◽  
Alberto José da Silva Duarte ◽  
Jorge Casseb
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Virus Type ◽  
Demographic Data ◽  
Laboratory Parameters ◽  
Hcv Genotype ◽  
Cell Counts ◽  
Human T Cell

Hepatitis C virus (HCV) and human T-cell lymphotropic virus type 1 (HTLV-1) share routes of transmission and some individuals have dual infection. Although some studies point to a worse prognosis of hepatitis C virus in patients co-infected with HTLV-1, the interaction between these two infections is poorly understood. This study evaluated the influence of HTLV-1 infection on laboratory parameters in chronic HCV patients. Twelve HTLV-1/HCV-coinfected patients were compared to 23 patients infected only with HCV, in regard to demographic data, risk factors for viral acquisition, HCV genotype, presence of cirrhosis, T CD4+ and CD8+ cell counts and liver function tests. There was no difference in regard to age, gender, alcohol consumption, smoking habits, HCV genotype or presence of cirrhosis between the groups. Intravenous drug use was the most common risk factor among individuals co-infected with HTLV-1. These patients showed higher TCD8+ counts (p = 0.0159) and significantly lower median values of AST and ALT (p = 0.0437 and 0.0159, respectively). In conclusion, we have shown that HCV/HTLV-1 co-infected patients differs in laboratorial parameters involving both liver and immunological patterns. The meaning of these interactions in the natural history of these infections is a matter that deserves further studies.

scholarly journals Comparative study of impulsiveness and risk behaviors among infected individuals with hepatitis C virus and human T-cell lymphotropic virus type 1

2020 ◽  
Vol 19 (2) ◽  
pp. 166-171 ◽  
Author(s):  
Ricardo Henrique-Araújo ◽  
Lucas C. Quarantini ◽  
Mychelle Morais-de-Jesus ◽  
Ana Paula Jesus-Nunes ◽  
Adriana Dantas-Duarte ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Comparative Study ◽  
Risk Behaviors ◽  
Virus Type ◽  
Human T Cell

scholarly journals Hepatitis C virus and human T-cell lymphotropic virus type 1 co-infection: impact on liver disease, virological markers, and neurological outcomes

2017 ◽  
Vol 57 ◽  
pp. 116-122 ◽  
Author(s):  
Otávio M. Espíndola ◽  
Alexandre G. Vizzoni ◽  
Elisabeth Lampe ◽  
Maria José Andrada-Serpa ◽  
Abelardo Q.C. Araújo ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
T Cell ◽  
Virus Type ◽  
Neurological Outcomes ◽  
Human T Cell

scholarly journals Quality of life, risk behaviors and depression among carriers of hepatitis C virus and human T-cell lymphotropic virus type 1: a comparative study

2019 ◽  
Vol 23 (4) ◽  
pp. 224-230
Author(s):  
Ricardo Henrique-Araújo ◽  
Lucas C. Quarantini ◽  
André C. Caribé ◽  
Felipe C. Argolo ◽  
Ana Paula Jesus-Nunes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Comparative Study ◽  
Risk Behaviors ◽  
Virus Type ◽  
Human T Cell

scholarly journals Iatrogenic Transmission of Human T Cell Lymphotropic Virus Type 1 and Hepatitis C Virus through Parenteral Treatment and Chemoprophylaxis of Sleeping Sickness in Colonial Equatorial Africa

2010 ◽  
Vol 51 (7) ◽  
pp. 777-784 ◽  
Author(s):  
Jacques Pépin ◽  
Annie‐Claude Labbé ◽  
Fleurie Mamadou‐Yaya ◽  
Pascal Mbélesso ◽  
Sylvestre Mbadingaï ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Virus Type ◽  
Sleeping Sickness ◽  
Parenteral Treatment ◽  
Equatorial Africa ◽  
Human T Cell ◽  
Iatrogenic Transmission

scholarly journals Differences in the Ability of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Tax To Inhibit p53 Function

2000 ◽  
Vol 74 (15) ◽  
pp. 6866-6874 ◽  
Author(s):  
Renaud Mahieux ◽  
Cynthia A. Pise-Masison ◽  
Paul F. Lambert ◽  
Christophe Nicot ◽  
Laura De Marchis ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
P53 Protein ◽  
State Level ◽  
Functional Difference ◽  
Reporter Plasmid ◽  
Virus Infected Cell ◽  
Human T Cell

ABSTRACT We have analyzed the functional activity of the p53 tumor suppressor in human T-cell lymphotropic virus type 2 (HTLV-2)-transformed cells. Abundant levels of the p53 protein were detected in both HTLV-2A and -2B virus-infected cell lines. The p53 was functionally inactive, however, both in transient-transfection assays using a p53 reporter plasmid and in induction of p53-responsive genes in response to gamma irradiation. We further investigated HTLV-2A Tax and HTLV-2B Tax effects on p53 activity. Interestingly, although Tax-2A and -2B inactivate p53, the Tax-2A protein appears to inhibit p53 function less efficiently than either Tax-1 or Tax-2B. In transient-cotransfection assays, Tax-1 and Tax-2B inactivated p53 by 80%, while Tax2A reduced p53 activity by 20%. In addition, Tax-2A does not increase the steady-state level of cellular p53 as well as Tax-1 or -2B does in the same assays. Cotransfection assays demonstrated that Tax-2A could efficiently transactivate CREB-responsive promoters to the same level as Tax-1 and Tax-2B, indicating that the protein was functional. This report provides evidence of the first functional difference between the HTLV-2A and -2B subtypes. This comparison of the action of HTLV-1 and HTLV-2 Tax proteins on p53 function will provide important insights into the mechanism of HTLV transformation.

scholarly journals Influence of Human T Cell Lymphotropic Virus Type 2 Coinfection on Virological and Immunological Parameters in HIV Type 1–Infected Patients

2007 ◽  
Vol 44 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Sylvina Bassani ◽  
Mariola Lopez ◽  
Carlos Toro ◽  
Victoria Jimenez ◽  
Jose M. Sempere ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Immunological Parameters ◽  
Human T Cell ◽  
Hiv Type 1

scholarly journals Preexisting Infection with Human T-Cell Lymphotropic Virus Type 2 neither Exacerbates nor Attenuates Simian Immunodeficiency Virus SIVmac251 Infection in Macaques

2010 ◽  
Vol 84 (6) ◽  
pp. 3043-3058 ◽  
Author(s):  
Shari N. Gordon ◽  
Anna R. Weissman ◽  
Valentina Cecchinato ◽  
Claudio Fenizia ◽  
Zhong-Min Ma ◽  
...  
Keyword(s):  
T Cell ◽  
Simian Immunodeficiency Virus ◽  
Virus Type ◽  
Rhesus Macaques ◽  
T Cell Response ◽  
Lymphoid Tissues ◽  
Human T Cell ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Coinfection with human T-cell lymphotropic virus type 2 (HTLV-2) and human immunodeficiency virus type 1 (HIV-1) has been reported to have either a slowed disease course or to have no effect on progression to AIDS. In this study, we generated a coinfection animal model and investigated whether HTLV-2 could persistently infect macaques, induce a T-cell response, and impact simian immunodeficiency virus SIVmac251-induced disease. We found that inoculation of irradiated HTLV-2-infected T cells into Indian rhesus macaques elicited humoral and T-cell responses to HTLV-2 antigens at both systemic and mucosal sites. Low levels of HTLV-2 provirus DNA were detected in the blood, lymphoid tissues, and gastrointestinal tracts of infected animals. Exposure of HTLV-2-infected or naïve macaques to SIVmac251 demonstrated comparable levels of SIVmac251 viral replication, similar rates of mucosal and peripheral CD4+ T-cell loss, and increased T-cell proliferation. Additionally, neither the magnitude nor the functional capacity of the SIV-specific T-cell-mediated immune response was different in HTLV-2/SIVmac251 coinfected animals versus SIVmac251 singly infected controls. Thus, HTLV-2 targets mucosal sites, persists, and importantly does not exacerbate SIVmac251 infection. These data provide the impetus for the development of an attenuated HTLV-2-based vectored vaccine for HIV-1; this approach could elicit persistent mucosal immunity that may prevent HIV-1/SIVmac251 infection.

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