scholarly journals Urine Liver-Type Fatty Acid-Binding Protein and Kidney Injury Molecule-1 in HIV-Infected Patients Receiving Combined Antiretroviral Treatment Based on Tenofovir

2014 ◽  
Vol 30 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Elżbieta Jabłonowska ◽  
Kamila Wójcik ◽  
Anna Piekarska
Keyword(s):  
Fatty Acid ◽  
Antiretroviral Treatment ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Kidney Injury ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Kidney Injury Molecule 1

scholarly journals Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury

2009 ◽  
Vol 296 (4) ◽  
pp. F669-F679 ◽  
Author(s):  
Eisei Noiri ◽  
Kent Doi ◽  
Kousuke Negishi ◽  
Tamami Tanaka ◽  
Yoshifumi Hamasaki ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Kidney Disease ◽  
Transgenic Mice ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Kidney Injury ◽  
Predictive Biomarker ◽  
Clinical Samples ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

In the development of novel therapeutic strategies for kidney disease, new renal biomarkers for early detection and accurate evaluation of renal injury are urgently required for both acute kidney injury (AKI) and chronic kidney disease (CKD). Fatty acid-binding protein 1 (FABP1) is expressed in renal proximal tubule cells and shed into urine in response to hypoxia caused by decreased peritubular capillary blood flow. To clarify the role of urinary FABP1 in kidney disease, we established human FABP1 transgenic mice and evaluated the responses of FABP1 to several AKI and CKD models. Moreover, there are accumulating clinical data that urinary FABP1 can detect human AKI earlier than serum creatinine and can distinguish the risk population for AKI. Investigation with “humanized” FABP1 transgenic mice and measurement of clinical samples allowed us to develop urinary FABP1 as a new renal biomarker. Further clinical studies are necessary to confirm the potential of urinary FABP1 for clinical application.

scholarly journals Performance of Urinary Liver-Type Fatty Acid–Binding Protein in Acute Kidney Injury: A Meta-analysis

2013 ◽  
Vol 61 (3) ◽  
pp. 430-439 ◽  
Author(s):  
Paweena Susantitaphong ◽  
Monchai Siribamrungwong ◽  
Kent Doi ◽  
Eisei Noiri ◽  
Norma Terrin ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Fatty Acid Binding ◽  
Acid Binding Protein
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