scholarly journals Short Communication: Atazanavir-Based Therapy Is Associated with Higher Hepatitis C Viral Load in HIV Type 1-Infected Subjects with Untreated Hepatitis C

2013 ◽  
Vol 29 (2) ◽  
pp. 223-225 ◽  
Author(s):  
Antonio Rivero-Juarez ◽  
Jose A. Mira ◽  
Ignacio Santos-Gil ◽  
Luis F. Lopez-Cortes ◽  
Jose A Girón-Gonzalez ◽  
...  
2015 ◽  
Author(s):  
Fouzia Ashraf ◽  
Dalaq Aiysha ◽  
Muhammad Tajamal ◽  
Shahzeb Shahzeb Javed ◽  
Saamia Saamia Tahir ◽  
...  

Background: Coinfection, bacterial or viral origin, in HIV infected individuals remains to be the only leading cause of deaths. This study was designed to analyze received plasma samples and plasma samples of referred patients for HIV testing to detect HIV and HCV mono and co-infection by real time PCR and finding co-relation of viral load of both viruses. Highlight and magnify the hidden coinfection, prior to seroconversion, of HIV type-1 and Hepatitis C Virus in received samples. Methods: Analyses were based on randomly selected 78 patients’ stored plasmas. Plasma samples were tested for both, HIV-type 1 and HCV viral RNA by real time PCR. Statistical formulas were used to identify men and the inter quartile range of patients age. The data were analyzed by IBM SPSS Statistics 21 (SPSS Inc., Chicago, IL). Study variables include gender, age and viral loads of HIV type-1 and HCV. Pearson correlation was used to evaluate any correlation in study variables. Result: Prevalence of HCV was 10.3%, HIV-type 1 was 19.2% and their co-infection was 37.2 percent. Thirty three percent individuals had no infection of both viruses. Gender based distribution showed that 74.4% (58/78) sample population was male. The mono-infection and co-infection was higher in males (39.7%) and highest viral load too. There was a positive correlation (CI= 95%) between the two variables; HIV and HCV viral loads, as r = 0.736, n=29, p= 0.001. Conclusion: Prevalence of HIV type-1 and HCV mono-infection and co-infection was higher among males as compared to females. Increased viral load was also evident among male co-infected individuals. This study proved the emergence of HCV coinfection in HIV infected individuals, and a need for on time diagnosis and treatment. I


2012 ◽  
Vol 28 (10) ◽  
pp. 1301-1304 ◽  
Author(s):  
Viviane K. Alves-Sousa ◽  
Shirley C.V. Komninakis ◽  
Giovana L. Baggio-Zappia ◽  
Aline J. Barbosa ◽  
Nathália P. Mantovani ◽  
...  

2013 ◽  
Vol 29 (1) ◽  
pp. 84-88 ◽  
Author(s):  
John N.S. Gregson ◽  
Leticia Kuri-Cervantes ◽  
Christopher M. Mela ◽  
Brian G. Gazzard ◽  
Mark Bower ◽  
...  

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Ramadan A. Mahmoud ◽  
Abdel-Azeem M. El-Mazary ◽  
Ashraf Khodeary

Background. Frequent blood transfusions in thalassemia major children expose them to the risk of transfusion-transmitted infections (TTIs). The aim of this study was to estimate the prevalence of hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), and cytomegalovirus (CMV) in thalassemic children attending the Pediatrics Departments of both Sohag and Minia Universities of Upper Egypt, during the period from May 2014 to May 2015.Methods. Serum samples were screened for hepatitis B surface antigen (HBsAg), anti-HCV, anti-CMV, and anti-HIV type 1 and type 2 using the Vitek Immunodiagnostic Assay System.Results. The frequencies of anti-HCV, HBsAg, anti-CMV, and anti-HIV type 1 and type 2 were found to be 37.11%, 4.12%, 4.12%, 0.00%, and 0.00%, respectively. Seropositivity for anti-HCV, HBsAg, and anti-CMV increased with increasing age of the patients, duration of the disease, serum ferritin level (ng/mL), and liver enzymes (U/L), while it was not significantly associated with gender, frequency of blood transfusion, or the status of splenectomy operation (P>0.05).Conclusion. The frequency of TTIs, especially HCV, is considerably high among Egyptian children with thalassemia major. It is therefore important to implement measures to improve blood transfusion screening, such as polymerase chain reaction, in order to reduce TTIs from blood donor units.


1999 ◽  
Vol 123 (11) ◽  
pp. 1011-1014
Author(s):  
Frederick S. Nolte

Abstract Quantitative human immunodeficiency virus (HIV) type 1 RNA tests have been essential tools in increasing our understanding of HIV pathogenesis and antiretroviral therapy. The plasma HIV RNA level is among the most powerful predictive tests in modern medicine for disease progression and has rapidly become the standard of practice for guiding clinicians in initiating, monitoring, and changing antiretroviral therapy. In this article the scientific rationale and clinical indications for viral load testing in HIV infection are reviewed.


1997 ◽  
Vol 13 (4) ◽  
pp. 327-335 ◽  
Author(s):  
S.M. BRUISTEN ◽  
P.H.J. FRISSEN ◽  
P. VAN SWIETEN ◽  
P.R. HARRIGAN ◽  
I. KINGHORN ◽  
...  

2004 ◽  
Vol 20 (8) ◽  
pp. 816-818 ◽  
Author(s):  
Emanuele Nicastri ◽  
Loredana Sarmati ◽  
Gabriella D'Ettorre ◽  
Saverio G. Parisi ◽  
Lucia Palmisano ◽  
...  

2008 ◽  
Vol 24 (9) ◽  
pp. 1133-1138 ◽  
Author(s):  
Maria Mercedes Santoro ◽  
Massimo Ciccozzi ◽  
Claudia Alteri ◽  
Stefania Montieri ◽  
Ivailo Alexiev ◽  
...  

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