scholarly journals Tax Gene Characterization of Human T-Lymphotropic Virus Type 1 Strains from Brazilian HIV-Coinfected Patients

2012 ◽  
Vol 28 (12) ◽  
pp. 1775-1778 ◽  
Author(s):  
Mariana Cavalheiro Magri ◽  
Luis Fernando de Macedo Brigido ◽  
Rosangela Rodrigues ◽  
Helena Kaminami Morimoto ◽  
Adele Caterino-de-Araujo
Keyword(s):  
Virus Type ◽  
Gene Characterization ◽  
T Lymphotropic Virus

Characterization of a B-cell immunodominant epitope of human T-lymphotropic virus type 1 (HTLV-I) envelope gp46

1992 ◽  
Vol 66 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Michael D. Lairmore ◽  
Donna L. Rudolph ◽  
Beverly D. Roberts ◽  
Charlene S. Dezzutti ◽  
Renu B. Lal
Keyword(s):  
B Cell ◽  
Virus Type ◽  
Immunodominant Epitope ◽  
T Lymphotropic Virus ◽  
Envelope Gp46

scholarly journals Human T-Lymphotropic Virus Type 1 Infection in a Patient with Arthritis in Mozambique: Molecular Characterization of Human T-Lymphotropic Virus Type 1 Isolate

2011 ◽  
Vol 27 (12) ◽  
pp. 1255-1257
Author(s):  
Adele Caterino-de-Araujo ◽  
Mariana Cavalheiro Magri ◽  
Emanuela Avelar Silva Costa ◽  
Rolanda Carmen Rafael Manuel
Keyword(s):  
Molecular Characterization ◽  
Virus Type ◽  
T Lymphotropic Virus

Drug Targets in Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection

2009 ◽  
Vol 9 (2) ◽  
pp. 159-171 ◽  
Author(s):  
Peter Boross ◽  
Peter Bagossi ◽  
Irene Weber ◽  
Jozsef Tozser
Keyword(s):  
Virus Type ◽  
Drug Targets ◽  
T Lymphotropic Virus

The Role of Human T-Lymphotropic Virus Type 1 (HTLV-1)-Infected Dendritic Cells in the Development of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

1999 ◽  
Vol 73 (6) ◽  
pp. 4575-4581 ◽  
Author(s):  
Masahiko Makino ◽  
Satoshi Shimokubo ◽  
Shin-Ichi Wakamatsu ◽  
Shuji Izumo ◽  
Masanori Baba
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Virus Type ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Normal Donor ◽  
Dependent Manner ◽  
T Lymphotropic Virus

ABSTRACT The development of human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is closely associated with the activation of T cells which are HTLV-1 specific but may cross-react with neural antigens (Ags). Immature dendritic cells (DCs), differentiated from normal donor monocytes by using recombinant granulocyte-macrophage colony-stimulating factor and recombinant interleukin-4, were pulsed with HTLV-1 in vitro. The pulsed DCs contained HTLV-1 proviral DNA and expressed HTLV-1 Gag Ag on their surface 6 days after infection. The DCs matured by lipopolysaccharides stimulated autologous CD4+ T cells and CD8+ T cells in a viral dose-dependent manner. However, the proliferation level of CD4+ T cells was five- to sixfold higher than that of CD8+ T cells. In contrast to virus-infected DCs, DCs pulsed with heat-inactivated virions activated only CD4+ T cells. To clarify the role of DCs in HAM/TSP development, monocytes from patients were cultured for 4 days in the presence of the cytokines. The expression of CD86 Ag on DCs was higher and that of CD1a Ag was more down-regulated than in DCs generated from normal monocytes. DCs from two of five patients expressed HTLV-1 Gag Ag. Furthermore, both CD4+ and CD8+ T cells from the patients were greatly stimulated by contact with autologous DCs pulsed with inactivated viral Ag as well as HTLV-1-infected DCs. These results suggest that DCs are susceptible to HTLV-1 infection and that their cognate interaction with T cells may contribute to the development of HAM/TSP.

Evaluation of iron, ferritin, copper, and ceruloplasmin along with proviral load in human T lymphotropic virus type 1–associated myelopathy

2021 ◽  
Author(s):  
Reza Boostani ◽  
Mina Khodabandeh ◽  
Seyyed Abdolrahim Rezaee ◽  
Houshang Rafatpanah ◽  
Sanaz Ahmadi Ghezeldasht ◽  
...  
Keyword(s):  
Virus Type ◽  
Proviral Load ◽  
T Lymphotropic Virus
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