scholarly journals Short Communication: Broader T Cell Responses Directed Against Human Immunodeficiency Virus Type 1 in Infected Chinese Individuals Through Blood-Borne Transmission in Comparison with Mucosal Transmission

2013 ◽  
Vol 29 (1) ◽  
pp. 89-93
Author(s):  
Dongyan Zhou ◽  
Xin Zhang ◽  
Weihua Li ◽  
Xiaoning Xu ◽  
Nilu Goonetilleke ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Short Communication ◽  
T Cell Responses ◽  
Mucosal Transmission ◽  
Cell Responses ◽  
Immunodeficiency Virus

scholarly journals Potentially Exposed but Uninfected Individuals Produce Cytotoxic and Polyfunctional Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Which Can Be Defined to the Epitope Level

2008 ◽  
Vol 15 (11) ◽  
pp. 1745-1748 ◽  
Author(s):  
A. L. Erickson ◽  
C. B. Willberg ◽  
V. McMahan ◽  
A. Liu ◽  
S. P. Buchbinder ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Cytotoxic T Lymphocyte ◽  
T Cell Responses ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Sex With Men

ABSTRACT We measured CD8+ T-cell responses in 12 potentially exposed but uninfected men who have sex with men by using cytokine flow cytometry. Four of the individuals screened exhibited polyfunctional immune responses to human immunodeficiency virus type 1 Gag or Vif. The minimum cytotoxic T lymphocyte epitope was mapped in one Gag responder.

scholarly journals Detection of Antibody-Dependent Complement-Mediated Inactivation of both Autologous and Heterologous Virus in Primary Human Immunodeficiency Virus Type 1 Infection

2005 ◽  
Vol 79 (5) ◽  
pp. 2823-2830 ◽  
Author(s):  
Marlén M. I. Aasa-Chapman ◽  
Sophie Holuigue ◽  
Keith Aubin ◽  
MaiLee Wong ◽  
Nicola A. Jones ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
T Cell Responses ◽  
Igg Antibodies ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Specific CD8 T-cell responses to human immunodeficiency virus type 1 (HIV-1) are induced in primary infection and make an important contribution to the control of early viral replication. The importance of neutralizing antibodies in containing primary viremia is questioned because they usually arise much later. Nevertheless antienvelope antibodies develop simultaneously with, or even before, peak viremia. We determined whether such antibodies might control viremia by complement-mediated inactivation (CMI). In each of seven patients studied, antibodies capable of CMI appeared at or shortly after the peak in viremia, concomitantly with detection of virus-specific T-cell responses. The CMI was effective on both autologous and heterologous HIV-1 isolates. Activation of the classical pathway and direct viral lysis were at least partly responsible. Since immunoglobulin G (IgG)-antibodies triggered the CMI, specific memory B cells could also be induced by vaccination. Thus, consideration should be given to vaccination strategies that induce IgG antibodies capable of CMI.

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