New Trends of Primary Drug Resistance Among HIV Type 1-Infected Men Who Have Sex with Men in Liaoning Province, China

2011 ◽  
Vol 27 (10) ◽  
pp. 1047-1053 ◽  
Author(s):  
Bin Zhao ◽  
Xiaoxu Han ◽  
Di Dai ◽  
Jing Liu ◽  
Haibo Ding ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Liaoning Province ◽  
Primary Drug Resistance ◽  
Hiv Type 1 ◽  
Sex With Men ◽  
Primary Drug

Prevalence of Primary Drug Resistance-Associated Mutations Among HIV Type 1 Vertically Infected Children in Belo Horizonte, Brazil

2010 ◽  
Vol 26 (2) ◽  
pp. 229-232 ◽  
Author(s):  
F.G.F. Ferreira ◽  
J.A. Pinto ◽  
F.M. Kakehasi ◽  
S. Cleto ◽  
U. Tupinambás ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Primary Drug Resistance ◽  
Hiv Type 1 ◽  
Belo Horizonte ◽  
Primary Drug

The emergence of HIV-1 primary drug resistance genotypes among treatment-naïve men who have sex with men in high-prevalence areas in China

2012 ◽  
Vol 158 (4) ◽  
pp. 839-844 ◽  
Author(s):  
Juan Yang ◽  
Hui Xing ◽  
Jianli Niu ◽  
Lingjie Liao ◽  
Yuhua Ruan ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Primary Drug Resistance ◽  
High Prevalence ◽  
Treatment Naïve ◽  
Sex With Men ◽  
Hiv 1 ◽  
Primary Drug

Genetic Diversity and Drug Resistance of HIV-1 CRF55_01B in Guangdong, China

2020 ◽  
Vol 18 (3) ◽  
pp. 210-218
Author(s):  
Guolong Yu ◽  
Yan Li ◽  
Xuhe Huang ◽  
Pingping Zhou ◽  
Jin Yan ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Reverse Transcriptase ◽  
Phylogenetic Analyses ◽  
Resistance Mutations ◽  
Protease Inhibition ◽  
Subtype B ◽  
Primary Drug Resistance ◽  
Hiv 1 ◽  
Primary Drug

Background: HIV-1 CRF55_01B was first reported in 2013. At present, no report is available regarding this new clade’s polymorphisms in its functionally critical regions protease and reverse transcriptase. Objective: To identify the diversity difference in protease and reverse transcriptase between CRF55_01B and its parental clades CRF01_AE and subtype B; and to investigate CRF55_01B’s drug resistance mutations associated with the protease inhibition and reverse transcriptase inhibition. Methods: HIV-1 RNA was extracted from plasma derived from a MSM population. The reverse transcription and nested PCR amplification were performed following our in-house PCR procedure. Genotyping and drug resistant-associated mutations and polymorphisms were identified based on polygenetic analyses and the usage of the HIV Drug Resistance Database, respectively. Results: A total of 9.24 % of the identified CRF55_01B sequences bear the primary drug resistance. CRF55_01B contains polymorphisms I13I/V, G16E and E35D that differ from those in CRF01_AE. Among the 11 polymorphisms in the RT region, seven were statistically different from CRF01_AE’s. Another three polymorphisms, R211K (98.3%), F214L (98.3%), and V245A/E (98.3 %.), were identified in the RT region and they all were statistically different with that of the subtype B. The V179E/D mutation, responsible for 100% potential low-level drug resistance, was found in all CRF55_01B sequences. Lastly, the phylogenetic analyses demonstrated 18 distinct clusters that account for 35% of the samples. Conclusions: CRF55_01B’s pol has different genetic diversity comparing to its counterpart in CRF55_01B’s parental clades. CRF55_01B has a high primary drug resistance presence and the V179E/D mutation may confer more vulnerability to drug resistance.

scholarly journals Primary drug resistance in antiretroviral-naïve injection drug users

2009 ◽  
Vol 13 (5) ◽  
pp. 577-583 ◽  
Author(s):  
Harout K. Tossonian ◽  
Jesse D. Raffa ◽  
Jason Grebely ◽  
Mark Viljoen ◽  
Annabel Mead ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Primary Drug Resistance ◽  
Primary Drug

scholarly journals Low Prevalence of Transmitted HIV Type 1 Drug Resistance Among Antiretroviral-Naive Adults in a Rural HIV Clinic in Kenya

2013 ◽  
Vol 29 (1) ◽  
pp. 129-135 ◽  
Author(s):  
Amin S. Hassan ◽  
Shalton M. Mwaringa ◽  
Clare A. Obonyo ◽  
Helen M. Nabwera ◽  
Eduard J. Sanders ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Hiv Type 1 ◽  
Low Prevalence
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