Differential Effects of P-Class Versus Other CpG Oligodeoxynucleotide Classes on the Impaired Innate Immunity of Plasmacytoid Dendritic Cells in HIV Type 1 Infection

2010 ◽  
Vol 26 (2) ◽  
pp. 161-171 ◽  
Author(s):  
Norbert Donhauser ◽  
Martin Helm ◽  
Kathrin Pritschet ◽  
Philipp Schuster ◽  
Moritz Ries ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Class Versus ◽  
Differential Effects ◽  
Cpg Oligodeoxynucleotide ◽  
Hiv Type 1

scholarly journals Monocyte‐Derived Dendritic Cells from HIV Type 1–Infected Individuals Show Reduced Ability to Stimulate T Cells and Have Altered Production of Interleukin (IL)–12 and IL‐10

2009 ◽  
Vol 199 (12) ◽  
pp. 1862-1871 ◽  
Author(s):  
Sandrine Buisson ◽  
Adel Benlahrech ◽  
Brian Gazzard ◽  
Frances Gotch ◽  
Peter Kelleher ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Hiv Type 1

scholarly journals CD4 Binding Affinity Determines Human Immunodeficiency Virus Type 1-Induced Alpha Interferon Production in Plasmacytoid Dendritic Cells

2008 ◽  
Vol 82 (17) ◽  
pp. 8900-8905 ◽  
Author(s):  
Sabrina Haupt ◽  
Norbert Donhauser ◽  
Chawaree Chaipan ◽  
Philipp Schuster ◽  
Bridget Puffer ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Dendritic Cells ◽  
Binding Affinity ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Plasmacytoid Dendritic Cells ◽  
Type I ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Plasmacytoid dendritic cells (PDC) are major producers of type I interferons (IFN) in response to human immunodeficiency virus type 1 (HIV-1) infection. To better define the underlying mechanisms, we studied the magnitude of alpha IFN (IFN-α) induction by recombinant viruses containing changes in the Env protein that impair or disrupt CD4 binding or expressing primary env alleles with differential coreceptor tropism. We found that the CD4 binding affinity but not the viral coreceptor usage is critical for the attachment of autofluorescing HIV-1 to PDC and for subsequent IFN-α induction. Our results illustrate the importance of the gp120-CD4 interaction in determining HIV-1-induced immune stimulation via IFN-α production.

scholarly journals Human Immunodeficiency Virus Type 1 Activates Plasmacytoid Dendritic Cells and Concomitantly Induces the Bystander Maturation of Myeloid Dendritic Cells

2004 ◽  
Vol 78 (10) ◽  
pp. 5223-5232 ◽  
Author(s):  
Jean-François Fonteneau ◽  
Marie Larsson ◽  
Anne-Sophie Beignon ◽  
Kelli McKenna ◽  
Ida Dasilva ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Dendritic Cells ◽  
T Cell ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Plasmacytoid Dendritic Cells ◽  
Myeloid Dendritic Cells ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT In this study, we analyzed the phenotypic and physiological consequences of the interaction of plasmacytoid dendritic cells (pDCs) with human immunodeficiency virus type 1 (HIV-1). pDCs are one cellular target of HIV-1 and respond to the virus by producing alpha/beta interferon (IFN-α/β) and chemokines. The outcome of this interaction, notably on the function of bystander myeloid DC (CD11c+ DCs), remains unclear. We therefore evaluated the effects of HIV-1 exposure on these two DC subsets under various conditions. Blood-purified pDCs and CD11c+ DCs were exposed in vitro to HIV-1, after which maturation markers, cytokine production, migratory capacity, and CD4 T-cell stimulatory capacity were analyzed. pDCs exposed to different strains of infectious or even chemically inactivated, nonreplicating HIV-1 strongly upregulated the expression of maturation markers, such as CD83 and functional CCR7, analogous to exposure to R-848, a synthetic agonist of toll-like receptor-7 and -8. In addition, HIV-1-activated pDCs produced cytokines (IFN-α and tumor necrosis factor alpha), migrated in response to CCL19 and, in coculture, matured CD11c+ DCs, which are not directly activated by HIV. pDCs also acquired the ability to stimulate naïve CD4+ T cells, albeit less efficiently than CD11c+ DCs. This HIV-1-induced maturation of both DC subsets may explain their disappearance from the blood of patients with high viral loads and may have important consequences on HIV-1 cellular transmission and HIV-1-specific T-cell responses.

Plasmacytoid dendritic cells—virus experts of innate immunity

2005 ◽  
Vol 17 (4) ◽  
pp. 253-261 ◽  
Author(s):  
Winfried Barchet ◽  
Marina Cella ◽  
Marco Colonna
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells

scholarly journals Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

2012 ◽  
Vol 12 (4) ◽  
pp. 558-570 ◽  
Author(s):  
Marlène Dreux ◽  
Urtzi Garaigorta ◽  
Bryan Boyd ◽  
Elodie Décembre ◽  
Josan Chung ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Dendritic Cells ◽  
Short Range ◽  
Plasmacytoid Dendritic Cells ◽  
Viral Rna ◽  
Infected Cells
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