Subtype B and Subtype C HIV Type 1 Recombinants in the Northeastern State of Manipur, India

2005 ◽  
Vol 21 (2) ◽  
pp. 152-157 ◽  
Author(s):  
Srikanth P. Tripathy ◽  
Smita S. Kulkarni ◽  
Sushama D. Jadhav ◽  
Kalpana D. Agnihotri ◽  
Abhay J. Jere ◽  
...  
Keyword(s):  
Subtype C ◽  
Subtype B ◽  
Northeastern State ◽  
Hiv Type 1

Prediction of HIV Type 1 Subtype C Tropism by Genotypic Algorithms Built From Subtype B Viruses

2010 ◽  
Vol 53 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Stéphanie Raymond ◽  
Pierre Delobel ◽  
Maud Mavigner ◽  
Laurent Ferradini ◽  
Michelle Cazabat ◽  
...  
Keyword(s):  
Subtype C ◽  
Subtype B ◽  
Hiv Type 1

scholarly journals Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
S. Sinha ◽  
H. Ahmad ◽  
R. C. Shekhar ◽  
N. Kumar ◽  
L. Dar ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Resistance Mutations ◽  
Subtype C ◽  
Hiv Drug Resistance ◽  
Northern India ◽  
Subtype B ◽  
Hiv Type 1 ◽  
Hiv 1

Objective. The increased use of antiretroviral therapy (ART) has reduced the morbidity and mortality associated with HIV, adversely leading to the emergence of HIV drug resistance (HIVDR). In this study we aim to evaluate the prevalence of HIVDR mutations in ART-naive HIV-1 infected patients from northern India.Design. Analysis was performed using Viroseq genotyping system based on sequencing of entire protease and two-thirds of the Reverse Transcriptase (RT) region ofpolgene.Results. Seventy three chronic HIV-1 infected ART naïve patients eligible for first line ART were enrolled from April 2006 to August 2008. In 68 patients DNA was successfully amplified and sequencing was done. 97% of HIV-1 strains belonged to subtype C, and one each to subtype A1 and subtype B. The overall prevalence of primary DRMs was 2.9% [2/68, 95% confidence interval (CI), 0.3%–10.2%]. One patient had a major RT mutation M184V, known to confer resistance to lamivudine, and another had a major protease inhibitor (PI) mutation D30N that imparts resistance to nelfinavir.Conclusion. Our study shows that primary HIVDR mutations have a prevalence of 2.9% among ART-naive chronic HIV-1 infected individuals.

scholarly journals Efficiencies of Four Versions of the AMPLICOR HIV-1 MONITOR Test for Quantification of Different Subtypes of Human Immunodeficiency Virus Type 1

1999 ◽  
Vol 37 (1) ◽  
pp. 110-116 ◽  
Author(s):  
K. Triques ◽  
J. Coste ◽  
J. L. Perret ◽  
C. Segarra ◽  
E. Mpoudi ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Viral Load ◽  
Pcr Primers ◽  
Load Test ◽  
Subtype C ◽  
Subtype B ◽  
Immunodeficiency Virus ◽  
Subtype A ◽  
Hiv 1

Three versions of a commercial human immunodeficiency virus (HIV) type 1 (HIV-1) load test (the AMPLICOR HIV-1 MONITOR Test versions 1.0, 1.0+, and 1.5; Roche Diagnostics, Branchburg, N.J.) were evaluated for their ability to detect and quantify HIV-1 RNA of different genetic subtypes. Plasma samples from 96 patients infected with various subtypes of HIV-1 (55 patients infected with subtype A, 9 with subtype B, 21 with subtype C, 2 with subtype D, 7 with subtype E, and 2 with subtype G) and cultured virus from 29 HIV-1 reference strains (3 of subtype A, 6 of subtype B, 5 of subtype C, 3 of subtype D, 8 of subtype E, 3 of subtype F, and 1 of subtype G) were tested. Detection of subtypes A and E was significantly improved with versions 1.0+ and 1.5 compared to that with version 1.0, whereas detection of subtypes B, C, D, and G was equivalent with the three versions. Versions 1.0, 1.0+, and 1.5 detected 65, 98, and 100% of the subtype A-infected samples from patients, respectively, and 71, 100, and 100% of the subtype E-infected samples from patients, respectively. Version 1.5 yielded a significant increase in viral load for samples infected with subtypes A and E (greater than 1 log10 HIV RNA copies/ml). For samples infected with subtype B, C, and D and tested with version 1.5, only a slight increase in viral load was observed (<0.5 log10). We also evaluated a prototype automated version of the test that uses the same PCR primers as version 1.5. The results with the prototype automated test were highly correlated with those of the version 1.5 test for all subtypes, but were lower overall. The AMPLICOR HIV-1 MONITOR Test, version 1.5, yielded accurate measurement of the HIV load for all HIV-1 subtypes tested, which should allow the test to be used to assess disease prognosis and response to antiretroviral treatment in patients infected with a group M HIV-1 subtype.

Phylogenetic Analysis of Multiple Heterosexual Transmission Events Involving Subtype B of HIV Type 1

2001 ◽  
Vol 17 (8) ◽  
pp. 689-695 ◽  
Author(s):  
Anna Hayman ◽  
Timothy Moss ◽  
Graham Simmons ◽  
Catherine Arnold ◽  
Edward C. Holmes ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Heterosexual Transmission ◽  
Subtype B ◽  
Hiv Type 1

Susceptibility to Etravirine of HIV Type 1 Subtype C Isolates from Nevirapine/Efavirenz-Experienced Patients: Comparative Interpretation of ANRS and STANFORD Algorithms

2012 ◽  
Vol 28 (12) ◽  
pp. 1793-1797 ◽  
Author(s):  
Delphine Anquetil ◽  
Alaka Deshpande ◽  
Drissa Zongo ◽  
Laurent Le Bihan ◽  
Patricia Recordon Pinson ◽  
...  
Keyword(s):  
Subtype C ◽  
Hiv Type 1

Differential Prevalence of HIV Type 1 Subtype B and CRF01_AE among Different Sexual Transmission Groups in Tokyo, Japan, as Revealed by Subtype-Specific PCR

2003 ◽  
Vol 19 (11) ◽  
pp. 1057-1063 ◽  
Author(s):  
Shingo Kato ◽  
Yuki Saito ◽  
Rie Tanaka ◽  
Yoshiyuki Hiraishi ◽  
Naoto Kitamura ◽  
...  
Keyword(s):  
Sexual Transmission ◽  
Specific Pcr ◽  
Subtype B ◽  
Hiv Type 1

scholarly journals Molecular Epidemiology Reveals Long‐Term Changes in HIV Type 1 Subtype B Transmission in Switzerland

2010 ◽  
Vol 201 (10) ◽  
pp. 1488-1497 ◽  
Author(s):  
Roger D. Kouyos ◽  
Viktor von Wyl ◽  
Sabine Yerly ◽  
Jürg Böni ◽  
Patrick Taffé ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Subtype B ◽  
Long Term Changes ◽  
Hiv Type 1
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