CD8+T Cell Supernatants of HIV Type 1-Infected Individuals Have Opposite Effects on Long Terminal Repeat-Mediated Transcription in T Cells and Monocytes

1997 ◽  
Vol 13 (1) ◽  
pp. 71-77 ◽  
Author(s):  
KAREN F.T. COPELAND ◽  
JONATHAN G. LEITH ◽  
PAULA J. McKAY ◽  
KENNETH L. ROSENTHAL
Keyword(s):  
T Cells ◽  
T Cell ◽  
Long Terminal Repeat ◽  
Cd8 T Cell ◽  
Terminal Repeat ◽  
Hiv Type 1

X Irradiation-Induced Transcription from the HIV Type 1 Long Terminal Repeat

1995 ◽  
Vol 11 (1) ◽  
pp. 41-43 ◽  
Author(s):  
E. FAURE ◽  
C. CAVARD ◽  
A. ZIDER ◽  
J.-P. GUILLET ◽  
M. RESBEUT ◽  
...  
Keyword(s):  
Long Terminal Repeat ◽  
Terminal Repeat ◽  
X Irradiation ◽  
Hiv Type 1

scholarly journals B cells modulate T cells so as to favour T helper type 1 and CD8+T-cell responses in the acute phase of Trypanosoma cruzi infection

Immunology ◽  
2007 ◽  
Vol 122 (4) ◽  
pp. 584-595 ◽  
Author(s):  
Fabiola Cardillo ◽  
Edilberto Postol ◽  
Jorge Nihei ◽  
Luiz S. Aroeira ◽  
Auro Nomizo ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
B Cells ◽  
Trypanosoma Cruzi ◽  
Cd8 T Cell ◽  
T Helper ◽  
Cell Responses ◽  
Cruzi Infection ◽  
Helper Type

Subtype-Specific Sequence Variation of the HIV Type 1 Long Terminal Repeat and Primer-Binding Site

2000 ◽  
Vol 16 (5) ◽  
pp. 499-504 ◽  
Author(s):  
Michel P. De Baar ◽  
Anthony De Ronde ◽  
Benjamin Berkhout ◽  
Marion Cornelissen ◽  
Karin H.M. Van Der Horn ◽  
...  
Keyword(s):  
Long Terminal Repeat ◽  
Binding Site ◽  
Sequence Variation ◽  
Terminal Repeat ◽  
Primer Binding Site ◽  
Specific Sequence ◽  
Hiv Type 1

scholarly journals Type 1 diabetes progression is associated with loss of CD3+CD56+ regulatory T cells that control CD8+ T-cell effector functions

2020 ◽  
Vol 2 (2) ◽  
pp. 142-152 ◽  
Author(s):  
Giuseppe Terrazzano ◽  
Sara Bruzzaniti ◽  
Valentina Rubino ◽  
Marianna Santopaolo ◽  
Anna Teresa Palatucci ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Regulatory T Cells ◽  
Cd8 T Cell ◽  
Effector Functions ◽  
Diabetes Progression ◽  
Cell Effector

scholarly journals Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

2012 ◽  
Vol 209 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Ken T. Coppieters ◽  
Francesco Dotta ◽  
Natalie Amirian ◽  
Peter D. Campbell ◽  
Thomas W.H. Kay ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Direct Proof ◽  
Hla Class I ◽  
Cd8 T Cell ◽  
Class I ◽  
Β Cell ◽  
Cell Reactivity

A direct association of islet-autoreactive T cells with β cell destruction in human pancreatic islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known about disease progression after diagnosis. Frozen pancreas samples were obtained from 45 cadaveric T1D donors with disease durations ranging from 1 wk to >50 yr, 14 nondiabetic controls, 5 nondiabetics with islet autoantibodies, 2 cases of gestational diabetes, and 6 T2D patients. Sections were systematically analyzed for the presence of insulin-sufficient β cells, CD8+ insulitic lesions, and HLA class I hyperexpression. Finally, consecutive sections from HLA-A2–expressing individuals were probed for CD8 T cell reactivity against six defined islet autoantigens associated with T1D by in situ tetramer staining. Both single and multiple CD8 T cell autoreactivities were detected within individual islets in a subset of patients up to 8 yr after clinical diagnosis. Pathological features such as HLA class I hyperexpression and insulitis were specific for T1D and persisted in a small portion of the patients with longstanding disease. Insulitic lesions consistently presented in a multifocal pattern with varying degrees of infiltration and β cell loss across affected organs. Our observations provide the first direct proof for islet autoreactivity within human islets and underscore the heterogeneous and chronic disease course.

Replication of HIV Type 1 in Rabbit Cell Lines Is Not Limited by Deficiencies intat, rev, or Long Terminal Repeat Function

1995 ◽  
Vol 11 (12) ◽  
pp. 1487-1493 ◽  
Author(s):  
SUNGAE CHO ◽  
THOMAS J. KINDT ◽  
TONG-MAO ZHAO ◽  
SANSANA SAWASDIKOSOL ◽  
BISHOP F. HAGUE
Keyword(s):  
Long Terminal Repeat ◽  
Cell Lines ◽  
Terminal Repeat ◽  
Hiv Type 1

scholarly journals Short Communication: CD8+ T Cell Polyfunctionality Profiles in Progressive and Nonprogressive Pediatric HIV Type 1 Infection

2011 ◽  
Vol 27 (9) ◽  
pp. 1005-1012 ◽  
Author(s):  
Christina F. Thobakgale ◽  
Hendrik Streeck ◽  
Nompumelelo Mkhwanazi ◽  
Zenele Mncube ◽  
Lungile Maphumulo ◽  
...  
Keyword(s):  
T Cell ◽  
Short Communication ◽  
Cd8 T Cell ◽  
Pediatric Hiv ◽  
Hiv Type 1
Sign in / Sign up

Export Citation Format

Share Document