Characterization of HIV Type 1 from Romanian Children: Lack of Correlation between V3 Loop Amino Acid Sequence and Syncytium Formation in MT-2 Cells

1995 ◽  
Vol 11 (5) ◽  
pp. 597-603 ◽  
Author(s):  
CAROL HOLM-HANSEN ◽  
DIETMAR GROTHUES ◽  
SIREN RUSTAD ◽  
BÅRD RØSOK ◽  
FLAVIA RODICA PASCU ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Syncytium Formation ◽  
V3 Loop ◽  
Hiv Type 1

Isolation and characterization of two new N-glycosidase type-1 ribosome-inactivating proteins, unrelated in amino-acid sequence, from Petrocoptis species

Planta ◽  
1994 ◽  
Vol 194 (4) ◽  
pp. 487-491 ◽  
Author(s):  
F. Javier Arias ◽  
M. Angeles Rojo ◽  
J. Miguel Ferreras ◽  
Rosario Iglesias ◽  
Raquel Muñoz ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Ribosome Inactivating Proteins ◽  
Isolation And Characterization

Characterization of V3 Loop Sequences from HIV Type 1 Subtype B in South Korea: Predominance of the GPGS Motif

1999 ◽  
Vol 15 (7) ◽  
pp. 681-686 ◽  
Author(s):  
Eun-Young Kim ◽  
Yeon-Sook Cho ◽  
Sung-Ho Maeng ◽  
Chun Kang ◽  
Jeong-Gu Nam ◽  
...  
Keyword(s):  
South Korea ◽  
V3 Loop ◽  
Subtype B ◽  
Hiv Type 1

Sequence Note: Characterization of V3 Loop of HIV Type 1 Spreading Rapidly among Injection Drug Users of Manipur, India: A Molecular Epidemiological Perspective

1996 ◽  
Vol 12 (16) ◽  
pp. 1571-1573 ◽  
Author(s):  
SAMIRAN PANDA ◽  
GUANGQIANG WANG ◽  
SWARUP SARKAR ◽  
CARLOS M. PEREZ ◽  
SEKHAR CHAKRABORTY ◽  
...  
Keyword(s):  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
V3 Loop ◽  
Hiv Type 1

Sequence Note: Genetic Characterization of the V3 Loop Sequences of 21 HIV Type 1 Spanish Isolates from Hemophilia Patients

1998 ◽  
Vol 14 (16) ◽  
pp. 1487-1490
Author(s):  
M. ORTIZ ◽  
A. BERNAL ◽  
V. JIMENEZ ◽  
M. MAGALLON ◽  
A. GARCIA-SAIZ
Keyword(s):  
Genetic Characterization ◽  
V3 Loop ◽  
Hiv Type 1

scholarly journals Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: the Ariel Project for the Prevention of Transmission of HIV from Mother to Infant

1999 ◽  
Vol 73 (5) ◽  
pp. 3975-3985 ◽  
Author(s):  
Cara C. Wilson ◽  
R. Clark Brown ◽  
Bette T. Korber ◽  
Barbara M. Wilkes ◽  
Debbie J. Ruhl ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Sequence Variation ◽  
Amino Acid Sequence Variation ◽  
Immunodeficiency Virus ◽  
Immunologic Factors ◽  
Hiv Type 1 ◽  
Hiv 1

ABSTRACT Host immunologic factors, including human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL), are thought to contribute to the control of HIV type 1 (HIV-1) replication and thus delay disease progression in infected individuals. Host immunologic factors are also likely to influence perinatal transmission of HIV-1 from infected mother to infant. In this study, the potential role of CTL in modulating HIV-1 transmission from mother to infant was examined in 11 HIV-1-infected mothers, 3 of whom transmitted virus to their offspring. Frequencies of HIV-1-specific human leukocyte antigen class I-restricted CTL responses and viral epitope amino acid sequence variation were determined in the mothers and their infected infants. Maternal HIV-1-specific CTL clones were derived from each of the HIV-1-infected pregnant women. Amino acid substitutions within the targeted CTL epitopes were more frequently identified in transmitting mothers than in nontransmitting mothers, and immune escape from CTL recognition was detected in all three transmitting mothers but in only one of eight nontransmitting mothers. The majority of viral sequences obtained from the HIV-1-infected infant blood samples were susceptible to maternal CTL. These findings demonstrate that epitope amino acid sequence variation and escape from CTL recognition occur more frequently in mothers that transmit HIV-1 to their infants than in those who do not. However, the transmitted virus can be a CTL susceptible form, suggesting inadequate in vivo immune control.

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