The Effects of Dextrose Prolotherapy in Symptomatic Knee Osteoarthritis: A Randomized Controlled Study

2020 ◽  
Vol 26 (5) ◽  
pp. 409-417 ◽  
Author(s):  
Alketa T. Sert ◽  
Ekin I. Sen ◽  
Sina Esmaeilzadeh ◽  
Emel Ozcan
Keyword(s):  
Knee Osteoarthritis ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

scholarly journals Intramuscular Clodronate in Long-Term Treatment of Symptomatic Knee Osteoarthritis: A Randomized Controlled Study

Drugs in R&D ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 39-45
Author(s):  
Bruno Frediani ◽  
Carmela Toscano ◽  
Paolo Falsetti ◽  
Antonella Nicosia ◽  
Serena Pierguidi ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Term Treatment ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee ◽  
Long Term Treatment

scholarly journals Effect of acupotomy in knee osteoarthritis patients: study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Danghan Xu ◽  
Minghui Lee ◽  
Cihui Huang ◽  
Jia Wei ◽  
Mengxue Zhou ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Controlled Trial ◽  
Pharmacological Therapy ◽  
Controlled Study ◽  
Clinical Trial Registry ◽  
Muscle Strengthening ◽  
Safety Issues ◽  
Randomized Controlled ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee

Abstract Background Symptomatic knee osteoarthritis (KOA) is common in China. Pharmacological therapy is not the first recommendation because of its safety issues. Nonpharmacological therapy, such as lifestyle adjustments, weight loss, muscle strengthening, and aerobic exercise programs, is strongly recommended for KOA. However, these approaches may fail due to poor patient compliance. There is a lack of high-quality randomized controlled trials of acupotomy, an effective treatment for KOA. This study was designed to investigate the efficacy of acupotomy in patients with KOA. Methods A total of 136 patients will be enrolled at the First Affiliated Hospital of Guangzhou University of Chinese Medicine and assigned to the acupotomy group or sham acupotomy group according to the block randomization scheme. Patients in the acupotomy group will receive 2 sessions of acupotomy for 2 weeks (once a week). Patients in the sham group will receive 2 sessions of sham stimulation for 2 weeks (once a week). All patients will use indomethacin cream externally. The primary outcome will be the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the secondary outcomes will be the visual analog scale (VAS) score, plantar pressure distribution test result, X-ray examination findings, musculoskeletal ultrasound findings, maximum knee circumference, joint mobility, and quality of life. Measurements will be taken at baseline, 1 week after the end of treatment, and at the 3- and 6-month follow-ups. Discussion To the best of our knowledge, this will be the first single-blind, sham-controlled study of acupotomy. The outcome assessors will also be blinded. The aim of this work is to demonstrate the efficacy of acupotomy in treating KOA. Trial registration Chinese Clinical Trial Registry ChiCTR2000033047. Registered on 18 May 2020.

scholarly journals Comment on: Intravenous neridronate in the treatment of acute painful knee osteoarthritis: a randomized controlled study: reply

Rheumatology ◽  
2015 ◽  
Vol 54 (11) ◽  
pp. 2117-2118
Author(s):  
Massimo Varenna ◽  
Francesca Zucchi ◽  
Simonetta Failoni ◽  
Andrea Becciolini ◽  
Massimo Berruto
Keyword(s):  
Knee Osteoarthritis ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Painful Knee

scholarly journals A randomized controlled study for Yuanhu Zhitong dropping pills in the treatment of knee osteoarthritis

Medicine ◽  
2020 ◽  
Vol 99 (24) ◽  
pp. e20666 ◽  
Author(s):  
Yubiao Gu ◽  
Jin Huang ◽  
Honggang Guo ◽  
Xuewen Song ◽  
Jianguo Li ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled
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