Dose–Response Effect of Tualang Honey on Postprandial Antioxidant Activity and Oxidative Stress in Female Athletes: A Pilot Study

2017 ◽  
Vol 23 (12) ◽  
pp. 989-995 ◽  
Author(s):  
Nur Syamsina Ahmad ◽  
Azlina Abdul Aziz ◽  
Kin Weng Kong ◽  
Mohamad Shariff A. Hamid ◽  
Jadeera Phaik Geok Cheong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Pilot Study ◽  
Dose Response ◽  
Female Athletes ◽  
Response Effect ◽  
Dose Response Effect ◽  
Tualang Honey ◽  
And Oxidative Stress

Is Speed of Onset of Anti-anxiety Efficacy with Pregabalin Influenced by Starting Dose?

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
B. Herman ◽  
F. Mandel
Keyword(s):  
Dose Response ◽  
Change Score ◽  
Early Improvement ◽  
Response Effect ◽  
Starting Dose ◽  
Dsm Iv ◽  
The Mean ◽  
Dose Response Effect ◽  
Titration Schedule ◽  
Speed Of Onset

Objective:There appears to be no dose-response effect for pregabalin at doses of 300-600 mg, and a modest dose-response effect in the range of 150-300 mg. The goal of the current investigation was to determine the effect of the starting dose on the speed of onset of anxiolytic efficacy.Methods:Data were analyzed from 7 trials of outpatients with DSM-IV GAD and a HAM-A total score ≥18. Starting doses of pregabalin ranged from 100 mg (N=301) or 150 mg (N=104), to 200 mg (N=167) and 300 mg (N=388). Assessment of early improvement included the HAM-A total score and CGI-Severity and Improvement scores.Results:The mean Week 1 HAM-A change score was similar for a starting dose of 200 mg/d with no titration (-8.24) when compared to patients who started on 200 mg/d and then titrated up to 400 mg/d on Day 4 (-8.64). The mean Week 1 HAM-A change score was somewhat higher for patients started on 300 mg/d, and then titrated to 450 mg/d on Day 4/5 (-8.84) when compared to patients started on a lower (100/150 mg/d) dose and titrated on Day 5 to 400/450 mg/d (-7.32). Starting on a dose of 300 mg/d with no titration resulted in an intermediate Week 1 change score (-7.87). The interaction of starting dose and titration schedule with baseline anxiety severity will be summarized in detail.Conclusion:The initial dose of pregabalin appears to have only a weak effect on the speed of onset of anxiolytic improvement.

A Polyphenol-Based Multicomponent Nutraceutical in Dysmetabolism and Oxidative Stress: Results from a Pilot Study

2017 ◽  
Vol 15 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Roberto Corsi ◽  
Giovanni Mosti ◽  
Attilio Cavezzi ◽  
Simone Ugo Urso ◽  
Gayla Dimitrova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pilot Study ◽  
And Oxidative Stress

A single dose-response effect of aflatoxin B1 on rapid liver cancer induction in two strains of rats

1990 ◽  
Vol 46 (4) ◽  
pp. 664-668 ◽  
Author(s):  
Subhkij Angsubhakorn ◽  
Panisa Get-Ngern ◽  
Makoto Miyamoto ◽  
Natth Bhamarapravati
Keyword(s):  
Single Dose ◽  
Liver Cancer ◽  
Dose Response ◽  
Aflatoxin B1 ◽  
Response Effect ◽  
Cancer Induction ◽  
Dose Response Effect
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