Selecting an Accessory Device with a Metered-Dose Inhaler: Variable Influence of Accessory Devices on Fine Particle Dose, Throat Deposition, and Drug Delivery with Asynchronous Actuation from a Metered-Dose Inhaler

2001 ◽  
Vol 14 (3) ◽  
pp. 351-360 ◽  
Author(s):  
Warren Wilkes ◽  
James Fink ◽  
Rajiv Dhand
Keyword(s):  
Drug Delivery ◽  
Fine Particle ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Fine Particle Dose ◽  
Particle Dose ◽  
Metered Dose ◽  
Accessory Device ◽  
Variable Influence

scholarly journals Study of pressurised metered dose inhalers for the purpose of standardization of quality attributes characterizing uniformity of dosing

2021 ◽  
pp. 11-23
Author(s):  
Elena Bezuglaya ◽  
Nikolay Lyapunov ◽  
Vladimir Bovtenko ◽  
Igor Zinchenko ◽  
Yurij Stolper
Keyword(s):  
Particle Size ◽  
Fine Particle ◽  
Fine Particles ◽  
Average Dose ◽  
Metered Dose Inhalers ◽  
Fine Particle Dose ◽  
Particle Dose ◽  
Metered Dose ◽  
Delivered Dose

Aim. The purpose was to provide the rationale of test in regard to uniformity of fine particles dose for pressurised metered dose inhalers (pMDIs). Materials and methods. The pMDIs containing suspensions of salbutamol sulfate (SS) or solutions of beclometasone dipropionate (BD) were studied by laser diffraction and high performance liquid chromatography (HPLC). The particle size distribution of SS, the average dose mass and uniformity of dose mass, the average delivered dose and the uniformity of delivered dose, the average fine particles dose and uniformity of fine particles dose were determined. Apparatus A was used for assessment of fine particles dose. Results. The two analytical procedures for the quantitative determination of SS and BD by HPLC were validated in the ranges with low concentrations of these substances. The 5 medicinal products in pMDI dosage form were studied: 3 preparations were with SS and 2 ones contained BD. It was shown that three products with SS were very similar in regard to particle size distribution in containers and the average values of delivered dose were almost the same, but these products were different in the average dose mass and fine particle dose. According to the research results, the expediency of determining the average dose mass and the tests concerning uniformity of dosing of preparations by dose mass and by fine particle dose was substantiated. It was shown that in the case of pMDI the dosing of solutions of BD was more uniform compared to suspensions of SS. The approaches of leading and other pharmacopoeias concerning uniformity of dosing for pMDIs were critically discussed. The expediency of determination of uniformity of fine particle dose at the stage of pharmaceutical development was substantiated, as the therapeutic effect depends on fine particle dose. Issues concerning standardization pMDIs in regard to uniformity of fine particle dose were discussed. Conclusions. The expediency of standardization and quality control of pMDIs in regard to such attributes as the average dose mass, which characterizes the volume of the metering chamber of the valve as well as the uniformity of the dose mass and the uniformity of fine particle dose, which assure the therapeutic effect of each dose of the product was substantiated

Improvement in the drug delivery of salmeterol/fluticasone via a novel breath actuatedpressurized metered dose inhaler with a dose counter

2019 ◽  
Author(s):  
Jaideep Gogtay ◽  
Amol Tambe ◽  
Kiran Rote ◽  
Geena Malhotra ◽  
Braj Gaurav Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Metered Dose

PATIENT SATISFACTION IN USE OF SALBUTAMOL THROUGH METERED DOSE INHALER FOR TREATMENT OF WHEEZE IN ASTHMA

2021 ◽  
pp. 18-19
Author(s):  
Deena. E. ◽  
Ruma Nayak
Keyword(s):  
Drug Delivery ◽  
Patient Satisfaction ◽  
Treatment Outcome ◽  
Asthma Control ◽  
Dose Inhaler ◽  
Outcome Questionnaire ◽  
Metered Dose Inhaler ◽  
Assess Patient Satisfaction ◽  
High Satisfaction ◽  
Metered Dose

Objective: To investigate the patient satisfaction and the acceptability of salbutamol through Metered Dose Inhaler (MDI) in the treatment of wheeze in asthma. 34 participants between ages of 5 and 18 years were incl Methods: uded. Modied Pulmonary Index (MPI) score was used to assess the improvement after treatment with salbutamol delivered by inhaler.Pre and post treatment scores were used to assess treatment outcome. Questionnaire was used to assess patient satisfaction by interviewing parents of participants. After the use of inhaler, 12% participants had no change in symptoms Results: , while 6% showing worsening of symptoms. In the remaining 82%, the symptoms reduced. 2.9% were not at all satised with the treatment, while 20.6% were moderately satised with the treatment. 76.5% of the participants were highly satised with the treatment. The use of Metered dose inhaler with salbutamol is very Conclusion: effective in reducing wheeze and other symptoms in asthma. Even those with no improvement in symptoms had high satisfaction with the treatment using salbutamol through MDI. This mode of drug delivery can enhance adherence and asthma control.

Increasing the fine particle fraction of pressurised metered dose inhaler solutions with novel actuator shapes

2021 ◽  
Vol 597 ◽  
pp. 120341
Author(s):  
Daniel J. Duke ◽  
Dung T. Nguyen ◽  
Larissa Gomes dos Reis ◽  
Dina M. Silva ◽  
Adrian Neild ◽  
...  
Keyword(s):  
Fine Particle ◽  
Dose Inhaler ◽  
Fine Particle Fraction ◽  
Particle Fraction ◽  
Metered Dose Inhaler ◽  
Metered Dose ◽  
Pressurised Metered Dose Inhaler
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