Short Communication:N-Linked Glycosylation in the V3 Region of HIV Type 1 Surface Antigen Modulates Coreceptor Usage in Viral Infection

2001 ◽  
Vol 17 (16) ◽  
pp. 1473-1479 ◽  
Author(s):  
Yun Li ◽  
Marie-Anne Rey-Cuille ◽  
Shiu-Lok Hu
Keyword(s):  
Viral Infection ◽  
Surface Antigen ◽  
Coreceptor Usage ◽  
Hiv Type 1 ◽  
V3 Region

Isolates from Four Different HIV Type 1 Clades Circulating in Cuba Identified by DNA Sequence of the C2-V3 Region

2001 ◽  
Vol 17 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Carmen E. Gómez ◽  
Enrique Iglesias ◽  
Walmer Perdomo ◽  
Felipe Rolo ◽  
Madelín Blanco ◽  
...  
Keyword(s):  
Dna Sequence ◽  
Hiv Type 1 ◽  
V3 Region

Sequence Note: Characterization of HIV Type 1 gp120 V3 Region Sequences from Ugandan Infants

1998 ◽  
Vol 14 (15) ◽  
pp. 1391-1395 ◽  
Author(s):  
J.L. MELLQUIST ◽  
B. BOWMAN ◽  
L. KASTURI ◽  
L. GUAY ◽  
P. KATAAHA ◽  
...  
Keyword(s):  
Hiv Type 1 ◽  
V3 Region

HIV Type 1 V3 Region Primer-Induced Antibody Suppression Is Overcome by Administration of C4-V3 Peptides as a Polyvalent Immunogen

1995 ◽  
Vol 11 (2) ◽  
pp. 211-221 ◽  
Author(s):  
BARTON F. HAYNES ◽  
M. ANTHONY MOODY ◽  
CRAIG S. HEINLEY ◽  
BETTE KORBER ◽  
WILLIAM A. MILLARD ◽  
...  
Keyword(s):  
Hiv Type 1 ◽  
V3 Region

Sequence Note: Genetic Polymorphism of Envelope V3 Region of HIV Type 1 Subtypes A, C, and D from Nairobi, Kenya

1996 ◽  
Vol 12 (1) ◽  
pp. 75-78 ◽  
Author(s):  
V. ZACHAR ◽  
A.S. GOUSTIN ◽  
V. ZACHAROVA ◽  
H. HAGER ◽  
U. KOPPELHUS ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Hiv Type 1 ◽  
V3 Region

A Characteristic Change of Consensus Core Motif in the V3 Region of HIV Type 1 Clade B, but Not in Clade E, in Thailand

1997 ◽  
Vol 13 (3) ◽  
pp. 271-273 ◽  
Author(s):  
SATOSHI NAGANAWA ◽  
PANASDA ISARANGKURA NA AYUTTAYA ◽  
SUMLEE DUANGCHANDA ◽  
WATTANA AUWANIT ◽  
PAIJIT WARACHIT ◽  
...  
Keyword(s):  
Characteristic Change ◽  
Core Motif ◽  
Clade B ◽  
Hiv Type 1 ◽  
V3 Region

scholarly journals Characterization of V3 Sequence Heterogeneity in Subtype C Human Immunodeficiency Virus Type 1 Isolates from Malawi: Underrepresentation of X4 Variants

1999 ◽  
Vol 73 (8) ◽  
pp. 6271-6281 ◽  
Author(s):  
Li-Hua Ping ◽  
Julie A. E. Nelson ◽  
Irving F. Hoffman ◽  
Jody Schock ◽  
Suzanna L. Lamers ◽  
...  
Keyword(s):  
Basic Amino Acid ◽  
Coreceptor Usage ◽  
Sequence Variability ◽  
Subtype C ◽  
Subtype B ◽  
Immunodeficiency Virus ◽  
Pcr Products ◽  
V3 Region ◽  
Hiv 1

ABSTRACT We have examined the nature of V3 sequence variability among subtype C human immunodeficiency virus type 1 (HIV-1) sequences from plasma-derived viral RNA present in infected men from Malawi. Sequence variability was assessed by direct sequence analysis of the V3 reverse transcription-PCR products, examination of virus populations by a subtype C V3-specific heteroduplex tracking assay (V3-HTA), and selected sequence analysis of molecular clones derived from the PCR products. Sequence variability in V3 among the subtype C viruses was not associated with the presence of basic amino acid substitutions. This observation is in contrast to that for subtype B HIV-1, where sequence variability is associated with such substitutions, and these substitutions are determinants of altered coreceptor usage. Evolutionary variants in subtype C V3 sequences, as defined by the V3-HTA, were not correlated with the CD4 level in the infected person, while such a correlation was found with subtype B V3 sequences. Viruses were isolated from a subset of the subjects; all isolates used CCR5 and not CXCR4 as a coreceptor, and none was able to grow in MT-2 cells, a hallmark of the syncytium-inducing phenotype that is correlated with CXCR4 usage. The overall sequence variability of the subtype C V3 region was no greater than that of the conserved regions of gp120. This limited sequence variability was also a feature of subtype B V3 sequences that do not carry the basic amino acid substitutions associated with altered coreceptor usage. Our results indicate that altered coreceptor usage is rare in subtype C HIV-1 isolates in sub-Saharan Africa and that sequence variability is not a feature of the V3 region of env in the absence of altered coreceptor usage.

scholarly journals Distinct Sequence Patterns Characterize the V3 Region of HIV Type 1 gp120 from Subtypes A and C

2006 ◽  
Vol 22 (7) ◽  
pp. 703-708 ◽  
Author(s):  
Klára Felsövályi ◽  
Arthur Nádas ◽  
Susan Zolla-Pazner ◽  
Timothy Cardozo
Keyword(s):  
Sequence Patterns ◽  
Distinct Sequence ◽  
Hiv Type 1 ◽  
V3 Region
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