The Corpus Luteum Hormone. I. Experimental Relaxation of the Pelvic Ligaments of the Guinea Pig

1929 ◽  
Vol 2 (1) ◽  
pp. 59-79 ◽  
Author(s):  
Frederick L. Hisaw
Keyword(s):  
Guinea Pig ◽  
Corpus Luteum

The ultrastructure of the corpus luteum of the guinea-pig

1971 ◽  
Vol 115 (4) ◽  
pp. 473-493 ◽  
Author(s):  
Paula R. Crombie ◽  
Robert D. Burton ◽  
Nicola Ackland
Keyword(s):  
Guinea Pig ◽  
Corpus Luteum

Effects of a synthetic prostaglandin analogue, cloprostenol, on the corpus luteum of the guinea pig

1982 ◽  
Vol 24 (4) ◽  
pp. 519-526 ◽  
Author(s):  
T.I. Azmi ◽  
J.D. O'Shea ◽  
C.S. Lee ◽  
r.J. Rodgers
Keyword(s):  
Guinea Pig ◽  
Corpus Luteum ◽  
Prostaglandin Analogue

GONADAL HORMONES AND THE CONTROL OF OVULATION IN THE GUINEA-PIG

1972 ◽  
Vol 55 (3) ◽  
pp. 599-607 ◽  
Author(s):  
B. T. DONOVAN ◽  
A. N. LOCKHART
Keyword(s):  
Guinea Pig ◽  
Corpus Luteum ◽  
Acute Treatment ◽  
Gonadal Hormones ◽  
Time Of Day ◽  
Gonadal Steroids ◽  
Corpora Lutea ◽  
Plasma Progesterone ◽  
Gonadotrophin Secretion ◽  
Oestradiol Benzoate

SUMMARY The release of ovulating hormone after acute treatment with gonadal steroids, or corpus luteum removal on different days of the oestrous cycle, was studied in the guinea-pig. Injection of 25, 50 or 100 μg oestradiol or 2·5 mg progesterone on day 13 of the cycle had no effect upon gonadotrophin secretion as judged by follicular histology, but markedly altered the sizes of the corpora lutea of the previous ovulation. Treatment with oestradiol on day 14 did not elicit gonadotrophin secretion. However, administration of the same hormones to animals given 10 μg oestradiol benzoate 24 h earlier caused ovulation or follicular luteinization. Progesterone (2·5 mg) appeared least effective in stimulating gonadotrophin release; 25 μg oestradiol were more effective when given at 12.00 h than at 24.00 h but treatment with both hormones caused ovulation when given at either time of day. Luteal volumes were not affected. Removal of corpora lutea during the second half of the cycle advanced the time of expected ovulation to day 15 or earlier when the procedure was carried out on days 8 or 9, but not on days 10–13. It is concluded that 4–5 days must elapse between the fall in plasma progesterone level associated with corpus luteum regression and the release of ovulating hormone.

scholarly journals The functions of the corpus luteum. II.—The experimental production of placentomata in the mouse

1929 ◽  
Vol 104 (729) ◽  
pp. 183-188 ◽  
Keyword(s):  
Guinea Pig ◽  
Corpus Luteum ◽  
Luteal Phase ◽  
Corpora Lutea ◽  
Experimental Production ◽  
Unmated Female ◽  
Decidual Tissue ◽  
Uterine Mucosa

During the luteal phase of the cycle in many mammals, notably in the rabbit, ferret, and dog, the uterus undergoes changes which are designed to facilitate the implantation of the fertilised ovum. In other animals, such as the guinea-pig(5), the uterine changes during the luteal phase are histologically less obvious, but physiologically the uterine mucosa is in a peculiar condition of irritability. Injury to the mucosa at this time results in the production of large blocks of decidua-like tissue, to which the terms placentomata or deciduomata have been given. It has been shown by Marshall, Hammond, Loeb and others that the presence of the corpus luteum is essential for these post-ovulative uterine changes, and therefore that the corpus luteum is directly or indirectly responsible for their production. In the rabbit decidual tissue can only be induced to develop when functional corpora lutea are present in the ovary. In the guniea-pig (Loeb, 5) placentomata can be produced during the post-ovulation phase of the cycle in the unmated female, but in the rat Long and Evans (6) were unable to obtain a similar result. This discrepancy is undoubtedly due to the fact that in the short diœstrous cycle of the rat the corpora lutea undergo comparatively little development, whereas in the guinea-pig the cycle is longer and the corpora luteá are known to become active. During the pseudo-pregnancy which follows sterile copulation in the rat (Long and Evans, 6) and also during lactation (Corner and Warren, 2) placentomata can be produced. During both of these times corpora lutea develop to a greater extent than during the diœstrous cycle and become functional.

The Hormonal Control of the Guinea Pig Corpus Luteum During Early Pregnancy

1976 ◽  
Vol 27 (11) ◽  
pp. 1322-1325 ◽  
Author(s):  
Renzo Antonini ◽  
Terry T. Turner ◽  
Carl J. Pauerstein
Keyword(s):  
Guinea Pig ◽  
Corpus Luteum ◽  
Early Pregnancy ◽  
Hormonal Control

IN-VITRO STEROIDOGENESIS OF NEWLY FORMED CORPORA LUTEA AND THE NON-LUTEAL OVARY IN THE RAT, RABBIT, HAMSTER AND GUINEA-PIG

1980 ◽  
Vol 84 (1) ◽  
pp. 101-108 ◽  
Author(s):  
P. F. TERRANOVA ◽  
S. K. SAIDAPUR ◽  
G. S. GREENWALD
Keyword(s):  
Guinea Pig ◽  
Corpus Luteum ◽  
Ovarian Function ◽  
Serum Testosterone ◽  
The Other ◽  
Corpora Lutea ◽  
Serum Progesterone ◽  
Antral Follicles ◽  
Baseline Levels

The steroidogenic abilities of the newly formed corpus luteum (8–10 h after ovulation) and the non-luteal ovary were compared in the guinea-pig, hamster, rabbit and rat using an invitro incubation technique. Histologically, newly formed rat corpora lutea (CL) were highly luteinized whereas the CL of the rabbit and guinea-pig were only partially luteinized. The CL of the hamster showed the least amount of luteinization. Serum progesterone was highest in the rat (18 ± 3 (s.e.m.) ng/ml). In the hamster, it was about 8 ng/ml, whereas in the rabbit and guinea-pig it was about 1 ng/ml. Serum androstenedione ranged between 0·5 and 1 ng/ml. Serum testosterone was lowest in the hamster (60 pg/ml) and highest in the rabbit (470 pg/ml), whereas in the rat and guinea-pig, testosterone levels were similar (about 240 pg/ml). Serum oestrogens were at baseline levels in all species. The CL of the rat exhibited considerably greater steroidogenic ability than the CL of the other species, producing 70 ± 6 ng progesterone/mg per h, 215 ± 14 pg androstenedione/mg per h, 49 ± 3 pg testosterone/mg per h, 3 pg oestrone/mg per h and 1 pg oestradiol/mg per h. Rabbit CL produced only progesterone (7 ± 2 ng/mg per h). Newly formed hamster CL produced none of the above steroids. In general, the ability of the CL to produce progesterone in vitro correlated with the degree of luteinization found by histological observation. Guinea-pig CL were embedded deeply in the ovary and could not be obtained without damage. Consequently, a portion of the ovary containing a corpus luteum was incubated. There was no difference in the steroid production by this portion of the ovary compared with the non-luteal ovary. The non-luteal ovary of the rat produced the highest amount of progesterone (10 ± 2 ng/mg per h). The guinea-pig non-luteal ovary produced about 5 ± 2 ng progesterone/mg per h, whereas the non-luteal ovary of the rabbit did not produce any. On the other hand, the hamster non-luteal ovary lost progesterone. Non-luteal ovaries from all species produced androgens. The non-luteal ovary of the guinea-pig contained especially large numbers of atretic antral follicles. The guinea-pig non-luteal ovary produced extremely large amounts of androstenedione (1110 ± 210 pg/mg per h) and testosterone (606 ± 154 pg/mg per h) compared with the amounts produced by the non-luteal ovary of the rat, hamster and rabbit. In the non-luteal ovary, interstitium and atretic antral follicles are the probable source of androgens. Oestrogen production by the non-luteal ovary was at baseline levels in the four species studied correlating with the absence of healthy antral follicles. The results indicate the extreme species differences that exist in ovarian function in the early postovulatory period.

scholarly journals THE FORMATION OF THE CORPUS LUTEUM IN THE GUINEA-PIG.

JAMA ◽  
1906 ◽  
Vol XLVI (6) ◽  
pp. 416 ◽  
Author(s):  
LEO LOEB
Keyword(s):  
Guinea Pig ◽  
Corpus Luteum

EFFECT OF INTRA-UTERINE FOREIGN BODIES AND OF PROSTAGLANDIN ADMINISTRATION ON PROGESTERONE SECRETION DURING THE OESTROUS CYCLE OF THE GUINEA-PIG

1976 ◽  
Vol 70 (1) ◽  
pp. 39-45 ◽  
Author(s):  
F. R. BLATCHLEY ◽  
B. T. DONOVAN
Keyword(s):  
Guinea Pig ◽  
Corpus Luteum ◽  
Foreign Bodies ◽  
Glass Beads ◽  
Oestrous Cycle ◽  
Corpora Lutea ◽  
Blood Samples ◽  
Progesterone Secretion ◽  
Prostaglandin F

SUMMARY The response of the guinea-pig corpus luteum to the luteolytic influence of glass beads placed in the uterus, or to prostaglandin administration, was followed by assay of the progesterone content of blood samples collected daily. Following the introduction of glass beads into the uterus early in the cycle, the secretion of progesterone was curtailed. Treatment with prostaglandin F2α over days 4–6 or 6–8 of the cycle temporarily depressed progesterone release without shortening the life of the corpora lutea. When the drug was administered over days 8–10, 10–12 or 12–14 the depression in progesterone was not followed by any recovery. These observations indicate that the response of the corpora lutea to a luteolytic influence changes during the oestrous cycle.

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