scholarly journals Between- and Within-Individual Variation of Maternal Thyroid Hormone Deposition in Wild Great Tits (Parus major)

2019 ◽  
Vol 194 (4) ◽  
pp. E96-E108 ◽  
Author(s):  
Bin-Yan Hsu ◽  
Irene Verhagen ◽  
Phillip Gienapp ◽  
Veerle M. Darras ◽  
Marcel E. Visser ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Individual Variation ◽  
Parus Major ◽  
Maternal Thyroid

scholarly journals Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women

2009 ◽  
Vol 161 (6) ◽  
pp. 903-910 ◽  
Author(s):  
Malene Boas ◽  
Julie Lyng Forman ◽  
Anders Juul ◽  
Ulla Feldt-Rasmussen ◽  
Niels Erik Skakkebæk ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Thyroid Function ◽  
Individual Variation ◽  
Reference Intervals ◽  
Specific Reference ◽  
Longitudinal Course ◽  
Individual Variations ◽  
Maternal Thyroid ◽  
In Pregnancy

BackgroundAdaptive alterations in maternal physiology cause changes in thyroid hormone levels throughout pregnancy, and precise biochemical evaluation is thus highly dependent on gestation-specific reference intervals and expected intra-individual variation.ObjectiveThe aim of the study was the assessment of the intra-individual variation as well as the longitudinal course of thyroid hormones during normal pregnancy and factors that influence the normal reference range for thyroid function. For this purpose, a longitudinal statistical model was applied.DesignIn a cohort of 132 pregnant women, serial blood samples were obtained and ultrasound scans were performed throughout pregnancy.MethodsSerum levels of TSH, free and total thyroxine (T4), free and total triiodothyronine (T3) as well as autoantibodies against thyroid peroxidase and thyroglobulin were measured in 979 serum samples.ResultsIntra-individual variations of thyroid hormone concentrations were smaller than inter-individual variations (individuality index range: 0.38–0.71). Maternal height was positively associated with free T4 (FT4) (b=0.003; P=0.031) and pre-pregnancy body mass index with T3 and free T3 (b=0.017; <0.001 and b=0.007; P<0.001). Smoking was positively associated with T4 and FT4, but it was modulated by gestational age. Gestation-specific reference intervals for thyroid function variables from autoantibody-negative participants are presented.ConclusionsIn accordance with the data from nonpregnant adults, intra-individual variations of thyroid hormones were smaller than inter-individual variations also during pregnancy. In the evaluation of thyroid function in pregnancy, the individual longitudinal course of thyroid hormones rather than absolute values should be considered. We present a longitudinal model for the prediction of maternal thyroid function tests in pregnant women.

Assesment of Maternal Thyroid Hormone Profile and it’s Association with Fetal Outcome

2011 ◽  
Vol 4 (3) ◽  
pp. 357-358
Author(s):  
Dr. Aditi Choubey ◽  
◽  
Dr. T.M. Panchanadikar Dr. T.M. Panchanadikar ◽  
Dr. Alpesh Patel ◽  
Dr. Deven Jogal
Keyword(s):  
Thyroid Hormone ◽  
Fetal Outcome ◽  
Hormone Profile ◽  
Maternal Thyroid

Newborn Screening for Congenital Hypothyroidism: Recommended Guidelines

PEDIATRICS ◽  
1993 ◽  
Vol 91 (6) ◽  
pp. 1203-1209
Author(s):  
Keyword(s):  
Thyroid Hormone ◽  
Newborn Screening ◽  
Congenital Hypothyroidism ◽  
Placental Transfer ◽  
Fetal Brain ◽  
Iodothyronine Deiodinase ◽  
Screening Programs ◽  
Organ Systems ◽  
Fetal Hypothyroidism ◽  
Maternal Thyroid

Congenital hypothyroidism (CH) represents one of the most common preventable causes of mental retardation. The fetal hypothalamic-pituitary-thyroid axis begins to function by midgestation and is mature in the term infant at delivery. If fetal hypothyroidism develops, untoward effects may be demonstrated in certain organ systems, including the central nervous system and skeleton. However, most infants with CH appear normal at birth. Recent data suggest that the hypothyroid fetus is protected to a certain extent by placental transfer of maternal thyroid hormone; serum thyroxine (T4) levels in the cord blood of athyroid fetuses approximate one third of maternal levels.1 In addition, studies in animal models of hypothyroidism demonstrate increased levels of brain iodothyronine deiodinase, the enzyme which converts T4 to triiodothyronine (T3). In the hypothyroid fetus, this increased enzyme acting on T4 of maternal origin is sufficient to produce near normal fetal brain T3 concentrations.2 Thus, it appears that early detection and treatment of congenital hypothyroidism should have the potential to completely reverse the effects of fetal hypothyroidism in all but the most severe cases, for example, athyreotic infants born to mothers with thyroid problems resulting in inadequate placental transfer of maternal thyroid hormone. Since the development of pilot screening programs for CH in Quebec and Pittsburgh in 1974,3 newborn screening for CH has become routine in essentially all developed countries of the world and is under development in Eastern Europe, South America, Asia, and Africa. In North America it is estimated that more than 5 million newborns are screened, with approximately 1400 infants with congenital hypothyroidism detected annually.

Feto-Maternal Thyroid Hormone Relationships in Iodine Deficiency: An Experimental Approach

1993 ◽  
pp. 171-180 ◽  
Author(s):  
Gabriella Morreale de Escobar ◽  
María Jesús Obregón ◽  
Rosa Calvo ◽  
Francisco Escobar del Rey
Keyword(s):  
Thyroid Hormone ◽  
Iodine Deficiency ◽  
Experimental Approach ◽  
Maternal Thyroid

Maternal thyroid hormone deficiency affects the fetal neocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis

2012 ◽  
Vol 237 (2) ◽  
pp. 477-488 ◽  
Author(s):  
Vishwa Mohan ◽  
Rohit A. Sinha ◽  
Amrita Pathak ◽  
Leena Rastogi ◽  
Praveen Kumar ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Deficiency ◽  
Pool Rate ◽  
Maternal Thyroid

scholarly journals Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester

2017 ◽  
Vol 21 (1) ◽  
pp. 17-21
Author(s):  
Nandita Hazra ◽  
Binay Mitra ◽  
Reetika Pal
Keyword(s):  
Thyroid Hormone ◽  
Pregnant Women ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Specific Reference ◽  
Indian Women ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Maternal Thyroid ◽  
Stimulating Hormone

ABSTRACT Aim Maternal thyroid hormone levels during pregnancy are vital for the health of the mother as well as the developing child. Fetal growth is affected by maternal thyroid levels. Various physiological changes like alterations of thyroxine-binding globulins, human chorionic gonadotropin level, and changes in iodide metabolism affect maternal thyroid hormone levels. Therefore, reference intervals (RIs) for thyroid hormones in pregnant population require to be established separately from the general population. Materials and methods The RIs of serum triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were determined in healthy pregnant women by enzyme-linked immunosorbent assay (ELISA) technique after segregating them into three trimesters. This study was conducted in a 492-bedded zonal-level hospital. The reference population was chosen from a study population of pregnant women by strict inclusion and exclusion criteria. The assays were done by the most-commonly used, economical ELISA method employing standard kits. Tests were done using accurate and precise methods with proper quality control measures. Results The RIs were calculated from the central 95% of distribution of total T3, total T4, and TSH values located between 2.5 and 97.5 percentile values. The 0.90 confidence intervals for the upper and lower reference limits were calculated. The values thus obtained were different from those provided by the manufacturer kit literature. Conclusion It is recommended to determine one's own laboratory-specific, method-specific, trimester-wise RIs for maternal thyroid hormone status and use them for screening of pregnant women. How to cite this article Chakrabarty BK, Mitra B, Pal R, Hazra N. Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester. Indian J Med Biochem 2017;21(1):17-21.

scholarly journals Maternal thyroid hormone insufficiency during pregnancy and risk of neurodevelopmental disorders in offspring: A systematic review and meta-analysis

2018 ◽  
Vol 88 (4) ◽  
pp. 575-584 ◽  
Author(s):  
William Thompson ◽  
Ginny Russell ◽  
Genevieve Baragwanath ◽  
Justin Matthews ◽  
Bijay Vaidya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Hormone ◽  
Neurodevelopmental Disorders ◽  
Meta Analysis ◽  
Maternal Thyroid

Maternal Thyroid Hormone Deficiency During Gestation and Lactation Alters Metabolic and Thyroid Programming of the Offspring in the Adult Stage

2019 ◽  
Vol 51 (06) ◽  
pp. 381-388 ◽  
Author(s):  
Jorge Tapia-Martínez ◽  
Alejandra Paola Torres-Manzo ◽  
Margarita Franco-Colín ◽  
Marisol Pineda-Reynoso ◽  
Edgar Cano-Europa
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Gland ◽  
Body Mass ◽  
Adult Life ◽  
Mass Gain ◽  
Hormone Deficiency ◽  
Body Mass Gain ◽  
Maternal Thyroid

AbstractEnvironmental stimuli during critical developmental stages establish long-term physiological and structural patterns that “program” health during adult life. Little is known about how alterations in hormonal supply might have consequences in metabolic and thyroid programming. This work aims to prove that alterations in the supply of thyroid hormones during gestation and lactation have long-term consequences in the metabolic and thyroid programming of the offspring. Female Wistar rats were divided into euthyroid, hypothyroid, and hypothyroid with 20 μg/day of s.c. thyroxine (T4), replacement wet nurses. Rats were mating, and after birth, pups were grouped according to their wet nurses group. Milk quality of wet nurses was assessed on days 7, 14, and 21. Body mass gain and energy intake of the offspring were monitored for 28 weeks after weaning. At sacrifice, we extracted and weighed their thyroid gland and adipose reserves, and collected blood to measure its metabolic and thyroid profiles. Hypothyroid wet nurses presented a persistent low quality of milk, while both male and female hypothyroid offspring presented lower body mass gain, higher blood glucose, dyslipidemia, hyperinsulinemia, and hyperleptinemia, as well as lower total adipose reserves, but higher visceral reserve, diminished T3 and T4 concentrations, and lower weight of thyroid gland. Thyroxine replacement prevented all changes in both wet nurses and pups. We conclude that maternal thyroid hormone deficiency during congenital and lactation stages alters the metabolic and thyroid programming of the offspring, while the reestablishment of maternal thyroid status during critical periods of development can prevent these alterations.

Sign in / Sign up

Export Citation Format

Share Document