Application of Miniature Heart Rate Data Loggers for Use in Large Free-Moving Decapod Crustaceans: Method Development and Validation

2018 ◽  
Vol 91 (1) ◽  
pp. 731-739 ◽  
Author(s):  
Iain J. McGaw ◽  
S. Clay Steell ◽  
Travis E. Van Leeuwen ◽  
Erika J. Eliason ◽  
Steven J. Cooke
Keyword(s):  
Heart Rate ◽  
Method Development ◽  
Rate Data ◽  
Decapod Crustaceans ◽  
Heart Rate Data ◽  
Data Loggers ◽  
Method Development And Validation ◽  
Development And Validation

Trial Implantation of Heart Rate Data Loggers in Pinnipeds

2009 ◽  
Vol 73 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Jonathan A. Green ◽  
Martin Haulena ◽  
Ian L. Boyd ◽  
Don Calkins ◽  
Frances Gulland ◽  
...  
Keyword(s):  
Heart Rate ◽  
Rate Data ◽  
Heart Rate Data ◽  
Data Loggers

scholarly journals Implantation of subcutaneous heart rate data loggers in southern elephant seals (Mirounga leonina)

Polar Biology ◽  
2017 ◽  
Vol 40 (11) ◽  
pp. 2307-2312 ◽  
Author(s):  
Laureline L. Chaise ◽  
William Paterson ◽  
Timothy G. Laske ◽  
Susan L. Gallon ◽  
Dominic J. McCafferty ◽  
...  
Keyword(s):  
Heart Rate ◽  
Rate Data ◽  
Mirounga Leonina ◽  
Elephant Seals ◽  
Heart Rate Data ◽  
Data Loggers ◽  
Southern Elephant Seals

Correlation in the heart rate data

1998 ◽  
Vol 2 ◽  
pp. 141-148
Author(s):  
J. Ulbikas ◽  
A. Čenys ◽  
D. Žemaitytė ◽  
G. Varoneckas
Keyword(s):  
Nonlinear Dynamics ◽  
Experimental Data ◽  
Heart Rate ◽  
Time Series ◽  
Cardiovascular Function ◽  
Statistical Properties ◽  
Rate Data ◽  
Heart Rate Data ◽  
Dynamical Nature ◽  
Analysis Of Time Series

Variety of methods of nonlinear dynamics have been used for possibility of an analysis of time series in experimental physiology. Dynamical nature of experimental data was checked using specific methods. Statistical properties of the heart rate have been investigated. Correlation between of cardiovascular function and statistical properties of both, heart rate and stroke volume, have been analyzed. Possibility to use a data from correlations in heart rate for monitoring of cardiovascular function was discussed.

Bioanalytical Method Development and Validation for the Determination of Vasopressin Receptor Antagonist Conivaptan in Mouse Plasma at NanoLevel and its Pharmacokinetic Application

2019 ◽  
Vol 15 (5) ◽  
pp. 591-598 ◽  
Author(s):  
Haitham Alrabiah ◽  
Ahmed Bakheit ◽  
Sabray Attia ◽  
Gamal A.E. Mostafa
Keyword(s):  
Method Development ◽  
Internal Standard ◽  
Vasopressin Receptor ◽  
Mouse Plasma ◽  
Precipitation Procedure ◽  
Validation Parameters ◽  
The Us ◽  
Method Development And Validation ◽  
Development And Validation

Background: Conivaptan inhibits two of vasopressin receptor (vasopressin receptor V1a and V2). Conivaptan is used for the treatment of hyponatremia, and in some instances, for the treatment of the heart failure. Methods: The present study aimed to develop a simple, sensitive, and accurate HPLC with ultraviolet detection for the assay of conivaptan (CON) in mouse plasma using bisoprolol as internal standard (IS). A precipitation procedure was used to extract CON and the IS from the mouse plasma. CON was chromatographically separated using a C18 analytical column at 25°C. The separation was carried out using a mixture of phosphate buffer (50 mM): acetonitrile (60: 40, v/v, pH 4.5) with a flow rate of 1.0 mL/min and detection was performed at 240 nm. Results: The assay was validated according to the US Food and Drug (FDA) guidelines. The method demonstrated linearity over a concentration range of 150 - 2000 ng/mL (correlation coefficient: r 2 = 0.9985). The mean recovery of CON from the mouse plasma was 101.13%. All validation parameters for CON were within the acceptable range. Conclusion: The investigated method has been shown to be suitable for estimating the CON in plasma samples, and this method is sensitive and highly selective, allowing the estimation of its concentrations up to the nano-scale. The suggested method was successfully used in a pharmacokinetic study of CON in mouse plasma.

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