Isotopic Incorporation and the Effects of Fasting and Dietary Lipid Content on Isotopic Discrimination in Large Carnivorous Mammals

2016 ◽  
Vol 89 (3) ◽  
pp. 182-197 ◽  
Author(s):  
K. D. Rode ◽  
C. A. Stricker ◽  
J. Erlenbach ◽  
C. T. Robbins ◽  
S. G. Cherry ◽  
...  
2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Silvia Falcinelli ◽  
Ana Rodiles ◽  
Azadeh Hatef ◽  
Simona Picchietti ◽  
Lina Cossignani ◽  
...  

1998 ◽  
Vol 26 (2) ◽  
pp. S188-S188
Author(s):  
Janet Bennoson ◽  
Amanda Jones ◽  
Arshad Humayan ◽  
Steve Wootton

1988 ◽  
Vol 18 (2) ◽  
pp. 211-214 ◽  
Author(s):  
Germain J.P. Fernando-Warnakulasuriya ◽  
Kozo Tsuchida ◽  
Michael A. Wells

2009 ◽  
Vol 297 (2) ◽  
pp. G299-G305 ◽  
Author(s):  
Stephanie M. Yoder ◽  
Qing Yang ◽  
Tammy L. Kindel ◽  
Patrick Tso

After the ingestion of nutrients, secretion of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by the enteroendocrine cells increases rapidly. Previous studies have shown that oral ingestion of fat stimulates secretion of both incretins; however, it is unclear whether there is a dose-dependent relationship between the amount of lipid ingested and the secretion of the hormones in vivo. Recently, we found a higher concentration of the incretin hormones in intestinal lymph than in peripheral or portal plasma. We therefore used the lymph fistula rat model to test for a dose-dependent relationship between the secretion of GIP and GLP-1 and dietary lipid. Under isoflurane anesthesia, the major mesenteric lymphatic duct of male Sprague-Dawley rats was cannulated. Each animal received a single, intraduodenal bolus of saline or varying amounts of the fat emulsion Liposyn II (0.275, 0.55, 1.1, 2.2, and 4.4 kcal). Lymph was continuously collected for 3 h and analyzed for triglyceride, GIP, and GLP-1 content. In response to increasing lipid calories, secretion of triglyceride, GIP, and GLP-1 into lymph increased dose dependently. Interestingly, the response to changes in intraluminal lipid content was greater in GLP-1- than in GIP-secreting cells. The different sensitivities of the two cell types to changes in intestinal lipid support the concept that separate mechanisms may underlie lipid-induced GIP and GLP-1 secretion. Furthermore, we speculate that the increased sensitivity of GLP-1 to intestinal lipid content reflects the hormone's role in the ileal brake reflex. As lipid reaches the distal portion of the gut, GLP-1 is secreted in a dose-dependent manner to reduce intestinal motility and enhance proximal fat absorption.


Aquaculture ◽  
2014 ◽  
Vol 434 ◽  
pp. 355-361 ◽  
Author(s):  
Xinwen Yi ◽  
Fan Zhang ◽  
Wei Xu ◽  
Jun Li ◽  
Wenbing Zhang ◽  
...  

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