Effect of Reproduction on the Consistency of the Between–Line Type Divergence in Laboratory Mice Selected on Basal Metabolic Rate

2015 ◽  
Vol 88 (3) ◽  
pp. 328-335 ◽  
Author(s):  
Julita Sadowska ◽  
Andrzej K. Gębczyński ◽  
Marek Konarzewski
Keyword(s):  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Laboratory Mice ◽  
Line Type

Anatomic and Molecular Correlates of Divergent Selection for Basal Metabolic Rate in Laboratory Mice

2007 ◽  
Vol 80 (5) ◽  
pp. 491-499 ◽  
Author(s):  
Paweł Brzęk ◽  
Katarzyna Bielawska ◽  
Aneta Książek ◽  
Marek Konarzewski
Keyword(s):  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Divergent Selection ◽  
Laboratory Mice ◽  
Selection For

scholarly journals EVOLUTION OF BASAL METABOLIC RATE AND ORGAN MASSES IN LABORATORY MICE

Evolution ◽  
1995 ◽  
Vol 49 (6) ◽  
pp. 1239-1248 ◽  
Author(s):  
Marek Konarzewski ◽  
Jared Diamond
Keyword(s):  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Laboratory Mice

scholarly journals Significance of variation in basal metabolic rate in laboratory mice for translational experiments

2021 ◽  
Author(s):  
Paweł Brzęk ◽  
Andrzej Gębczyński ◽  
Piotr Selewestruk ◽  
Aneta Książek ◽  
Julita Sadowska ◽  
...  
Keyword(s):  
Physical Activity ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Activity Level ◽  
Laboratory Mice ◽  
Ambient Temperatures ◽  
Thermoneutral Zone ◽  
Significant Difference ◽  
The Mean ◽  
Spontaneous Physical Activity

AbstractThe basal metabolic rate (BMR) accounts for 60–70% of the daily energy expenditure (DEE) in sedentary humans and at least 50% of the DEE in laboratory mice in the thermoneutral zone. Surprisingly, however, the significance of the variation in the BMR is largely overlooked in translational research using such indices as physical activity level (PAL), i.e., the ratio of DEE/BMR. In particular, it is unclear whether emulation of human PAL in mouse models should be carried out within or below the thermoneutral zone. It is also unclear whether physical activity within the thermoneutral zone is limited by the capacity to dissipate heat generated by exercise and obligatory metabolic processes contributing to BMR. We measured PAL and spontaneous physical activity (SPA) in laboratory mice from two lines, divergently selected towards either high or low level of BMR, and acclimated to 30 °C (i.e., the thermoneutral zone), 23 or 4 °C. The mean PAL did not differ between both lines in the mice acclimated to 30 °C but became significantly higher in the low BMR mouse line at the lower ambient temperatures. Acclimation to 30 °C reduced the mean locomotor activity but did not affect the significant difference observed between the selected lines. We conclude that carrying out experiments within the thermoneutral zone can increase the consistency of translational studies aimed at the emulation of human energetics, without affecting the variation in physical activity correlated with BMR.

scholarly journals Basal metabolic rate is positively correlated with parental investment in laboratory mice

2013 ◽  
Vol 280 (1753) ◽  
pp. 20122576 ◽  
Author(s):  
Julita Sadowska ◽  
Andrzej K. Gębczyński ◽  
Marek Konarzewski
Keyword(s):  
Growth Rate ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Parental Investment ◽  
Foster Mother ◽  
Term Selection ◽  
Genetically Determined ◽  
Investment Capacity ◽  
Assimilation Capacity ◽  
Line Type

The assimilation capacity (AC) hypothesis for the evolution of endothermy predicts that the maternal basal metabolic rate (BMR) should be positively correlated with the capacity for parental investment. In this study, we provide a unique test of the AC model based on mice from a long-term selection experiment designed to produce divergent levels of BMR. By constructing experimental families with cross-fostered litters, we were able to control for the effect of the mother as well as the type of pup based on the selected lines. We found that mothers with genetically determined high levels of BMR were characterized by higher parental investment capacity, measured as the offspring growth rate. We also found higher food consumption and heavier visceral organs in the females with high BMR. These findings suggested that the high-BMR females have higher energy acquisition abilities. When the effect of the line type of a foster mother was controlled, the pup line type significantly affected the growth rate only in the first week of life, with young from the high-BMR line type growing more rapidly. Our results support the predictions of the AC model.

scholarly journals High basal metabolic rate does not elevate oxidative stress during reproduction in laboratory mice

2014 ◽  
Vol 217 (9) ◽  
pp. 1504-1509 ◽  
Author(s):  
P. Brz k ◽  
A. Ksi zek ◽  
 ukasz O dakowski ◽  
M. Konarzewski
Keyword(s):  
Oxidative Stress ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Laboratory Mice ◽  
High Basal Metabolic Rate
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