Parenteral to Oral Conversion of Fluoroquinolones: Low-Hanging Fruit for Antimicrobial Stewardship Programs?

2012 ◽  
Vol 33 (4) ◽  
pp. 362-367 ◽  
Author(s):  
Makoto Jones ◽  
Benedikt Huttner ◽  
Karl Madaras-Kelly ◽  
Kevin Nechodom ◽  
Christopher Nielson ◽  
...  
Keyword(s):  
Acute Care ◽  
Safety Issue ◽  
Antibiotic Use ◽  
The United States ◽  
Medication Administration ◽  
Veterans Affairs ◽  
Entire Study ◽  
Bar Code ◽  
Patient Safety Issue ◽  
Va Hospitals

Objective.To estimate avoidable intravenous (IV) fluoroquinolone use in Veterans Affairs (VA) hospitals.Design.A retrospective analysis of bar code medication administration (BCMA) data.Setting.Acute care wards of 128 VA hospitals throughout the United States.Methods.Data were analyzed for all medications administered on acute care wards between January 1, 2006, and December 31, 2010. Patient-days receiving therapy were expressed as fluoroquinolone-days (FD) and divided into intravenous (IV; all doses administered intravenously) and oral (PO; at least one dose administered per os) FD. We assumed IV fluoroquinolone use to be potentially avoidable on a given IV FD when there was at least 1 other medication administered via the enteral route.Results.Over the entire study period, 884,740 IV and 830,572 PO FD were administered. Overall, avoidable IV fluoroquinolone use accounted for 46.8% of all FD and 90.9% of IV FD. Excluding the first 2 days of all IV fluoroquinolone courses and limiting the analysis to the non-ICU setting yielded more conservative estimates of avoidable IV use: 20.9% of all FD and 45.9% of IV FD. Avoidable IV use was more common for levofloxacin and more frequent in the ICU setting. There was a moderate correlation between avoidable IV FD and total systemic antibiotic use (r = 0.32).Conclusions.Unnecessary IV fluoroquinolone use seems to be common in the VA system, but important variations exist between facilities. Antibiotic stewardship programs could focus on this patient safety issue as a “low-hanging fruit” to increase awareness of appropriate antibiotic use.

scholarly journals Association of Hospital-Onset Clostridium difficile Infection Rates and Antibiotic Use in US Acute Care Hospitals, 2006–2012: An Ecologic Analysis

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S1-S1 ◽  
Author(s):  
Sophia Kazakova ◽  
James Baggs ◽  
Lawrence McDonald ◽  
Sarah Yi ◽  
Kelly Hatfield ◽  
...  
Keyword(s):  
Acute Care ◽  
Inpatient Treatment ◽  
Acute Care Hospitals ◽  
Antibiotic Use ◽  
Estimating Equation ◽  
The United States ◽  
Fourth Generation ◽  
Days Of Therapy ◽  
Facility Level ◽  
Hospital Characteristics

Abstract Background This study investigated the association between facility-level rates of hospital-onset CDI (HO-CDI) and inpatient antibiotic use (AU) in a large group of U.S. acute care hospitals over a 7-year period. Methods We used adult discharge and antibiotic use data from 552 acute care hospitals participating in the Truven Health MarketScan Hospital Database from January 1, 2006 to December 31, 2012 to determine facility-level CDI rates and AU. HO-CDI was defined as a discharge with a secondary ICD-9-CM diagnosis code for CDI (008.45) and inpatient treatment with metronidazole or oral vancomycin. The relationship between facility-level HO-CDI (HO-CDI per 10,000 patient-days (PD)) and AU (days of therapy (DOT) per 1,000 PD) was examined through multivariate general estimating equation models that accounted for the correlation between annual HO-CDI rates within a hospital. The models controlled for hospital characteristics and a facility-level rate of community-onset CDI (CO-CDI), defined as a discharge with a primary ICD-9-CM code for CDI and inpatient treatment. Results During 2006 to 2012, the mean HO-CDI rate was 11 per 10,000 PD (interquartile range (IQR): 5.7–14.7) and mean AU was 811 DOT/1,000 PD (IQR: 710–932). After controlling for facility-level CO-CDI and other hospital characteristics, overall AU was significantly associated with facility-level HO-CDI rate; for every 50 DOT/1,000 PD increase in AU, there was a 4.4% increase in the HO-CDI rate. Similarly, the only antibiotic classes significantly associated with HO-CDI were third- and fourth-generation cephalosporins (P < 0.0001) and carbapenems (P = 0.0011) with respective increases of 2.1% and 2.4% of HO-CDI per 10 DOT/1,000 PD increase. Fluoroquinolones and β-lactam/β-lactamase inhibitor combinations were not significantly associated with HO-CDI. Conclusion In this ecologic analysis of over 500 hospitals, overall antibiotic use was associated with increased rates of HO-CDI. In contrast to recent patient-level analyses in the United States and national observations in England, only third- and fourth-generation cephalosporins and carbapenems were associated with HO-CDI. Disclosures All authors: No reported disclosures.

scholarly journals 1881. The Agency for Healthcare Research and Quality (AHRQ) Safety Program for Improving Antibiotic Use: Results From a National Antibiotic Stewardship Intervention of 402 United States (US) Hospitals

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S50-S50
Author(s):  
Pranita Tamma ◽  
Pranita Tamma ◽  
Melissa A Miller ◽  
Prashila Dullabh ◽  
Roy Ahn ◽  
...  
Keyword(s):  
Decision Making ◽  
Best Practices ◽  
Acute Care ◽  
Safety Issue ◽  
Antibiotic Use ◽  
Healthcare Research ◽  
Post Intervention ◽  
Frontline Staff ◽  
Safety Program ◽  
The Impact

Abstract Background The AHRQ Safety Program for Improving Antibiotic Use aims to improve antibiotic (abx) use in acute, long-term, and outpatient care settings by enhancing abx stewardship programs (ASP) and engaging frontline providers to incorporate stewardship into daily abx decision-making, with an emphasis on viewing appropriate prescribing as a patient safety issue. We report on the impact of implementation of the Acute Care Safety Program on abx use and Clostridioides difficile in a cohort of US hospitals. Methods The Acute Care Safety Program was implemented from December 2017 to November 2018. At least one unit from each hospital participated. The Safety Program trained local ASP leaders and assisted ASPs and frontline staff to: (a) address attitudes and culture that pose challenges to judicious abx use and (b) incorporate best practices for the management of common infections into daily practice using the Four Moments of Antibiotic Decision Making framework (Figure 1). Education occurred via 17 live Webinars and an online toolkit that included recorded Webinars, narrated presentations, and other tools to assist with the development and dissemination of syndrome-specific local guidelines (Table 1). Units submitted days of abx therapy (DOT) per 1,000 patient-days (PD), C. difficile LabID events per 10,000 PD, and 10 review forms per month documenting structured discussions between the ASP and frontline staff about patients on abx. Linear and generalized linear mixed-effects models were employed to calculate pre-post intervention changes in abx use and C. difficile LabID events, respectively. Results 402 hospitals completed the Safety Program, including 28 (7%) academic medical centers (AMC), 289 (72%) community hospitals, and 85 (21%) critical access hospitals. 476 participating units consisted of 165 (35%) ICUs, 300 (63%) medical-surgical floors, and 11 (2%) other units. Both abx use and C. difficile LabID events decreased when comparing pre-post data (−41 DOT per 1,000 PD, [from 886.56, Figure 2], P = 0.001 and −1.2 LabID events per 10,000 PD [from 6.3], P = 0.027), respectively. Conclusion By targeting both improving abx prescribing culture and knowledge of best practices, the AHRQ Safety Program led to reductions in abx use across a diverse cohort of hospitals. Disclosures Sara E. Cosgrove, MD, MS, Basilea: Consultant; Theravance: Consultant.

The Intersection of Patient Safety and Nursing Research

2006 ◽  
Vol 24 (1) ◽  
pp. 3-15
Author(s):  
Patricia H. Walker ◽  
Gaya Carlton ◽  
Lela Holden ◽  
Patricia W. Stone
Keyword(s):  
United States ◽  
Patient Safety ◽  
Human Error ◽  
Safety Issue ◽  
The United States ◽  
The Past ◽  
Safety Research ◽  
Federal Response ◽  
Patient Safety Issue ◽  
The Individual

The individual and collective discussions of the patient safety issue in the United States have mounted from a low roar to a deafening din in the past 10 years. In this chapter the authors (1) discuss the context of patient safety over the past decade and the federal response to the problem, (2) briefly present Reason’s theory of human error, which frames much of the safety research, and (3) provide a glossary of terms.

scholarly journals Policy Statement on Antimicrobial Stewardship by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), and the Pediatric Infectious Diseases Society (PIDS)

2012 ◽  
Vol 33 (4) ◽  
pp. 322-327 ◽  
Author(s):  
Neil Fishman ◽  
◽  
◽  
Keyword(s):  
United States ◽  
Infectious Diseases ◽  
Antimicrobial Stewardship ◽  
Safety Issue ◽  
The United States ◽  
Position Statement ◽  
Policy Statement ◽  
Antimicrobial Use ◽  
Patient Safety Issue ◽  
Healthcare Epidemiology

Antimicrobial resistance has emerged as a significant healthcare quality and patient safety issue in the twenty-first century that, combined with a rapidly dwindling antimicrobial armamentarium, has resulted in a critical threat to the public health of the United States. Antimicrobial stewardship programs optimize antimicrobial use to achieve the best clinical outcomes while minimizing adverse events and limiting selective pressures that drive the emergence of resistance and may also reduce excessive costs attributable to suboptimal antimicrobial use. Therefore, antimicrobial stewardship must be a fiduciary responsibility for all healthcare institutions across the continuum of care. This position statement of the Society for Healthcare Epidemiology of America, the Infectious Diseases Society of America, and the Pediatric Infectious Diseases Society of America outlines recommendations for the mandatory implementation of antimicrobial stewardship throughout health care, suggests process and outcome measures to monitor these interventions, and addresses deficiencies in education and research in this field as well as the lack of accurate data on antimicrobial use in the United States.

scholarly journals At a Rural Veterans Affairs Medical Center, Telehealth Decreased Antibiotic Use in Long-Term, but not Acute Care

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S275-S275
Author(s):  
Richard Banks ◽  
Roberto Viau ◽  
Brigid Wilson ◽  
Christopher Crnich ◽  
Emma Ide ◽  
...  
Keyword(s):  
Acute Care ◽  
Medical Center ◽  
Antibiotic Use ◽  
Veterans Affairs

scholarly journals Antibiotic use and presumptive pathogens in the Veterans Affairs Healthcare System

2021 ◽  
Author(s):  
Christine Tedijanto ◽  
McKenna Nevers ◽  
Matthew H Samore ◽  
Marc Lipsitch
Keyword(s):  
Healthcare System ◽  
Bacterial Pathogen ◽  
Antibiotic Use ◽  
The United States ◽  
Veterans Affairs ◽  
Bacterial Isolation ◽  
Specimen Collection ◽  
Days Of Therapy ◽  
Antibiotic Group ◽  
Bacterial Organism

Abstract Background Empirical antibiotic use is common in the hospital. Here, we characterize patterns of antibiotic use, infectious diagnoses, and microbiological lab results among hospitalized patients and aim to quantify the proportion of antibiotic use that is potentially attributable to specific bacterial pathogens. Methods We conducted an observational study using electronic health records from acute care facilities in the United States Veterans Affairs Healthcare System. From October 2017 to September 2018, 482,381 hospitalizations for 332,657 unique patients that met all criteria were included. At least one antibiotic was administered at 202,037 (41.9%) of included hospital stays. We measured frequency of antibiotic use, microbiological specimen collection, and bacterial isolation by diagnosis category and antibiotic group. A tiered system based on specimen collection sites and diagnoses was used to attribute antibiotic use to presumptive causative organisms. Results Specimens were collected at 130,012 (64.4%) hospitalizations with any antibiotic use, and at least one bacterial organism was isolated at 35.1% of these stays. Frequency of bacterial isolation varied widely by diagnosis category and antibiotic group. Under increasingly lenient criteria, 10.2% to 31.4% of 974,733 antibiotic days-of-therapy could be linked to a potential bacterial pathogen. Conclusions Overall, the vast majority of antibiotic use could be linked to either an infectious diagnosis or microbiological specimen. Nearly half of antibiotic use occurred when there was a specimen collected but no bacterial organism identified, underscoring the need for rapid and improved diagnostics to optimize antibiotic use.

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