scholarly journals A Defense of Syntax-Based Gene Concepts in Postgenomics: Genes as Modular Subroutines in the Master Genomic Program

2011 ◽  
Vol 78 (5) ◽  
pp. 712-723 ◽  
Author(s):  
Tudor M. Baetu
Keyword(s):  
Gene Concepts

scholarly journals IMPLEMENTASI ALAT PERAGA EDUKASI PIPLAS (PIPET PLASTIK) UNTUK MENINGKATKAN PEMAHAMAN IPA PADA SISWA DI SMP NEGERI 1 GANGGA

2020 ◽  
Vol 7 (2) ◽  
Author(s):  
Siti Nurkhasanah
Keyword(s):  
Learning Outcomes ◽  
Quantitative Approach ◽  
Educational Tool ◽  
Average Value ◽  
Gene Concepts

The study aims to increase the understanding of gene concepts and inheritance by providing a more concrete representation of the genes. The design of this research uses the quantitative approach of experimentation. Subjects and objects of study are students of grade IX-5 SMP Negeri 1 Gangga, amounting to 29 not one person until a total of 28 people. This Piplas educational tool is very simple because it only makes use of plastic pipettes used by ice-drinking students. Usually plastic pipettes are used for crafting, but are used to provide a concrete representation of the genes. The results showed that most students are easier to understand the concept of genes, capable of making crosses easily so as to improve learning outcomes. Tests were given before learning obtained an average value of 30.79 and after learning obtained an average value of 69.4 an increase of 125.4%.

Gene concepts in motion: from Mendel to molecules

1997 ◽  
pp. 146-154
Author(s):  
Jacqueline Girard-Bascou ◽  
Craig Holdrege
Keyword(s):  
Gene Concepts

scholarly journals Targeting the Transcriptome Through Globally Acting Components

2021 ◽  
Vol 12 ◽  
Author(s):  
Damien Parrello ◽  
Maria Vlasenok ◽  
Lincoln Kranz ◽  
Sergei Nechaev
Keyword(s):  
Rna Polymerase Ii ◽  
Cell Type ◽  
Basic Principles ◽  
Pol Ii ◽  
Specific Effects ◽  
Genome Wide ◽  
Cellular Machinery ◽  
Cell Type Specific ◽  
Pol Ii Pausing ◽  
Gene Concepts

Transcription is a step in gene expression that defines the identity of cells and its dysregulation is associated with diseases. With advancing technologies revealing molecular underpinnings of the cell with ever-higher precision, our ability to view the transcriptomes may have surpassed our knowledge of the principles behind their organization. The human RNA polymerase II (Pol II) machinery comprises thousands of components that, in conjunction with epigenetic and other mechanisms, drive specialized programs of development, differentiation, and responses to the environment. Parts of these programs are repurposed in oncogenic transformation. Targeting of cancers is commonly done by inhibiting general or broadly acting components of the cellular machinery. The critical unanswered question is how globally acting or general factors exert cell type specific effects on transcription. One solution, which is discussed here, may be among the events that take place at genes during early Pol II transcription elongation. This essay turns the spotlight on the well-known phenomenon of promoter-proximal Pol II pausing as a step that separates signals that establish pausing genome-wide from those that release the paused Pol II into the gene. Concepts generated in this rapidly developing field will enhance our understanding of basic principles behind transcriptome organization and hopefully translate into better therapies at the bedside.

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