scholarly journals QuantiFERON-TB Testing for Latent Tuberculosis Infection in Low-Prevalence Countries: Making the Most of an Imperfect Process

2011 ◽  
Vol 32 (10) ◽  
pp. 1055-1055 ◽  
Author(s):  
William J. Schneider ◽  
Arthur E. Brown ◽  
Cynthia Eisenstein
Keyword(s):  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Low Prevalence

scholarly journals Low Prevalence of Latent Tuberculosis Infection among Contacts of Smear-Positive Adults in Brazil

2019 ◽  
Vol 101 (5) ◽  
pp. 1077-1082
Author(s):  
Andreza Oliveira-Cortez ◽  
Emerson Lopes Froede ◽  
Angelita Cristine de Melo ◽  
Clemax Couto Sant’Anna ◽  
Leonardo Araújo Pinto ◽  
...  
Keyword(s):  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Low Prevalence

Latent Tuberculosis Infection Screening and 2-Year Outcome in Antiretroviral-Naive HIV-Infected Patients in a Low-Prevalence Country

2015 ◽  
pp. 150727131311009
Author(s):  
Anne Bourgarit ◽  
Gabriel Baron ◽  
Guillaume Breton ◽  
Pierre Tattevin ◽  
Christine Katlama ◽  
...  
Keyword(s):  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Low Prevalence

scholarly journals Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection

2011 ◽  
Vol 5 ◽  
pp. CMPed.S6406 ◽  
Author(s):  
Dan Desrochers ◽  
Regino P. González-Peralta ◽  
Daniel T. McClenathan ◽  
Michael J. Wilsey ◽  
Allah Haafiz
Keyword(s):  
Liver Failure ◽  
Hepatic Injury ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Transplant Center ◽  
Widespread Acceptance ◽  
Severe Liver Dysfunction ◽  
Low Prevalence ◽  
Inh Prophylaxis

Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center remains unpredictable. We report the management of a five year-old girl who developed progressive liver failure due to INH prophylaxis. This highlights the potential severity of INH related hepatic injury and underscores the significance of vigilant clinical monitoring throughout the duration of the therapy in children.

scholarly journals A Targeted Screening Program for Latent Tuberculosis Infection Among Hematopoietic Cell Transplant Recipients

2020 ◽  
Vol 7 (7) ◽  
Author(s):  
Andrea Sosa-Moreno ◽  
Masahiro Narita ◽  
Christopher Spitters ◽  
Michelle Swetky ◽  
Sara Podczervinski ◽  
...  
Keyword(s):  
Risk Factors ◽  
Latent Tuberculosis Infection ◽  
Screening Program ◽  
Latent Tuberculosis ◽  
Hematopoietic Cell ◽  
Tuberculosis Infection ◽  
Tuberculin Skin Testing ◽  
Targeted Screening ◽  
Low Prevalence ◽  
Ltbi Testing

Abstract Background US hematopoietic cell transplantation (HCT) recipients have a low prevalence of latent tuberculosis infection (LTBI), but if latently infected they are at risk for progression to active tuberculosis. At our center, all HCT recipients underwent LTBI testing pretransplant by tuberculin skin testing (TST) until 2013 when we implemented a targeted screening program. Our objective was to assess the utility of our screening program that incorporated a pretransplant LTBI questionnaire to target TST and QuantiFERON TB Gold (QFT) testing. Methods We performed a retrospective cohort study of HCT recipients undergoing first transplant from 2014 to 2016. Patients with positive, indeterminate, and a subset with negative QFT results underwent electronic medical record (EMR) review to assess TST results and risk factors for LTBI. Results Among 1290 eligible recipients, 457 (35%) had at least 1 risk factor for LTBI on the pretransplant questionnaire; nonwhites were more likely to undergo LTBI testing (P < .0001). Overall, 16 of 1290 (1.2%) had at least 1 positive LTBI test. Of those screened by QFT, 14 of 457 (3%) were positive and 52 (11%) were indeterminate. Among those undergoing EMR review, 123 of 267 (46%) had TST records; 4 of 123 (3%) positive by both TST and QFT, and 2 (2%) by TST alone. Two or more risk factors were reported among the majority of LTBI-positive patients (15 of 16 [94%]). All patients with at least 1 positive test for LTBI (n = 16) were evaluated, and 11 of 16 (69%) were recommended to receive treatment. Conclusions Incorporating a pretransplant LTBI questionnaire allowed for an approximate 65% reduction in LTBI testing when compared with universal testing among this low prevalence population.

LATENT TUBERCULOSIS INFECTION IN CHILDREN AS A PREREQUISITE FOR THE TUBERCULOSIS DEVELOPMENT IN ADULTS

2019 ◽  
Vol 98 (5) ◽  
pp. 179-181
Author(s):  
Yu.P. Chugaev ◽  
◽  
A.I. Tsvetkov ◽  
I.A. Chernyaev ◽  
N.G. Kamaeva ◽  
...  
Keyword(s):  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection
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