Prospective Evaluation of 2009 H1N1 Influenza A in Patients Admitted with Fever to an Oncology Unit

2011 ◽  
Vol 32 (8) ◽  
pp. 815-817 ◽  
Author(s):  
Karen Seiter ◽  
Dhaval Shah ◽  
Claudio Sandoval ◽  
Delong Liu ◽  
Robert B. Nadelman ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Infection Control ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Favorable Outcome ◽  
Prospective Evaluation ◽  
H1n1 Influenza Virus ◽  
Oncology Patients ◽  
2009 H1n1 ◽  
Oncology Unit

We prospectively evaluated all oncology inpatients for 2009 H1N1 influenza virus. All patients recovered completely. Evaluating all oncology patients with fever for influenza involved overtreatment of influenza-negative patients and involved a significant infection control burden. However, early antiviral intervention could have contributed to a favorable outcome.

Development of a multiplex real-time RT-PCR assay for detection of influenza A, influenza B, RSV and typing of the 2009-H1N1 influenza virus

2010 ◽  
Vol 167 (2) ◽  
pp. 113-118 ◽  
Author(s):  
Weston C. Hymas ◽  
Alan Mills ◽  
Sheri Ferguson ◽  
Janine Langer ◽  
Rosemary C. She ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Real Time ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Influenza B ◽  
Rt Pcr ◽  
H1n1 Influenza Virus ◽  
Pcr Assay ◽  
2009 H1n1

scholarly journals Sequential Seasonal H1N1 Influenza Virus Infections Protect Ferrets against Novel 2009 H1N1 Influenza Virus

2012 ◽  
Vol 87 (3) ◽  
pp. 1400-1410 ◽  
Author(s):  
Donald M. Carter ◽  
Chalise E. Bloom ◽  
Eduardo J. M. Nascimento ◽  
Ernesto T. A. Marques ◽  
Jodi K. Craigo ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
Cross Reactivity ◽  
Influenza Viruses ◽  
The Novel ◽  
Virus Infections ◽  
H1n1 Influenza Virus ◽  
Virus Shedding ◽  
2009 H1n1 ◽  
Novel H1n1 Influenza

ABSTRACTIndividuals <60 years of age had the lowest incidence of infection, with ∼25% of these people having preexisting, cross-reactive antibodies to novel 2009 H1N1 influenza. Many people >60 years old also had preexisting antibodies to novel H1N1. These observations are puzzling because the seasonal H1N1 viruses circulating during the last 60 years were not antigenically similar to novel H1N1. We therefore hypothesized that a sequence of exposures to antigenically different seasonal H1N1 viruses can elicit an antibody response that protects against novel 2009 H1N1. Ferrets were preinfected with seasonal H1N1 viruses and assessed for cross-reactive antibodies to novel H1N1. Serum from infected ferrets was assayed for cross-reactivity to both seasonal and novel 2009 H1N1 strains. These results were compared to those of ferrets that were sequentially infected with H1N1 viruses isolated prior to 1957 or more-recently isolated viruses. Following seroconversion, ferrets were challenged with novel H1N1 influenza virus and assessed for viral titers in the nasal wash, morbidity, and mortality. There was no hemagglutination inhibition (HAI) cross-reactivity in ferrets infected with any single seasonal H1N1 influenza viruses, with limited protection to challenge. However, sequential H1N1 influenza infections reduced the incidence of disease and elicited cross-reactive antibodies to novel H1N1 isolates. The amount and duration of virus shedding and the frequency of transmission following novel H1N1 challenge were reduced. Exposure to multiple seasonal H1N1 influenza viruses, and not to any single H1N1 influenza virus, elicits a breadth of antibodies that neutralize novel H1N1 even though the host was never exposed to the novel H1N1 influenza viruses.

scholarly journals Unique Finding of a 2009 H1N1 Influenza Virus-Positive Clinical Sample Suggests Matrix Gene Sequence Variation

2009 ◽  
Vol 48 (2) ◽  
pp. 665-666 ◽  
Author(s):  
X. Zheng ◽  
K. M. Todd ◽  
B. Yen-Lieberman ◽  
K. Kaul ◽  
K. Mangold ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Sequence Variation ◽  
Gene Sequence ◽  
Clinical Sample ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Matrix Gene ◽  
2009 H1n1

scholarly journals No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine

Gene ◽  
2012 ◽  
Vol 494 (2) ◽  
pp. 242-245 ◽  
Author(s):  
Maciej F. Boni ◽  
Gavin J.D. Smith ◽  
Edward C. Holmes ◽  
Dhanasekaran Vijaykrishna
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
2009 H1n1

Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (δ-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus

Vaccine ◽  
2011 ◽  
Vol 29 (15) ◽  
pp. 2712-2719 ◽  
Author(s):  
Phillip C. Gauger ◽  
Amy L. Vincent ◽  
Crystal L. Loving ◽  
Kelly M. Lager ◽  
Bruce H. Janke ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
2009 H1n1

scholarly journals Contemporary Seasonal Influenza A (H1N1) Virus Infection Primes for a More Robust Response To Split Inactivated Pandemic Influenza A (H1N1) Virus Vaccination in Ferrets

2010 ◽  
Vol 17 (12) ◽  
pp. 1998-2006 ◽  
Author(s):  
Ali H. Ellebedy ◽  
Thomas P. Fabrizio ◽  
Ghazi Kayali ◽  
Thomas H. Oguin ◽  
Scott A. Brown ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
H1n1 Virus ◽  
H1n1 Influenza ◽  
Influenza Viruses ◽  
Inactivated Vaccine ◽  
H1n1 Influenza Virus ◽  
Influenza A H1n1

ABSTRACT Human influenza pandemics occur when influenza viruses to which the population has little or no immunity emerge and acquire the ability to achieve human-to-human transmission. In April 2009, cases of a novel H1N1 influenza virus in children in the southwestern United States were reported. It was retrospectively shown that these cases represented the spread of this virus from an ongoing outbreak in Mexico. The emergence of the pandemic led to a number of national vaccination programs. Surprisingly, early human clinical trial data have shown that a single dose of nonadjuvanted pandemic influenza A (H1N1) 2009 monovalent inactivated vaccine (pMIV) has led to a seroprotective response in a majority of individuals, despite earlier studies showing a lack of cross-reactivity between seasonal and pandemic H1N1 viruses. Here we show that previous exposure to a contemporary seasonal H1N1 influenza virus and to a lesser degree a seasonal influenza virus trivalent inactivated vaccine is able to prime for a higher antibody response after a subsequent dose of pMIV in ferrets. The more protective response was partially dependent on the presence of CD8+ cells. Two doses of pMIV were also able to induce a detectable antibody response that provided protection from subsequent challenge. These data show that previous infection with seasonal H1N1 influenza viruses likely explains the requirement for only a single dose of pMIV in adults and that vaccination campaigns with the current pandemic influenza vaccines should reduce viral burden and disease severity in humans.

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