scholarly journals Using Oral Vancomycin Prescriptions as a Proxy Measure forClostridium difficileInfections: A Spatial and Time Series Analysis

2011 ◽  
Vol 32 (7) ◽  
pp. 723-726 ◽  
Author(s):  
Philip M. Polgreen ◽  
Ming Yang ◽  
Jennifer L. Kuntz ◽  
Ramanan Laxminarayan ◽  
Joseph E. Cavanaugh

Sales for a drug may be correlated with the prevalence of a condition treated by the drug. We found that state data revealed a strong spatial association and national data a strong temporal association betweenClostridium difficileand oral vancomycin prescription sales, suggesting a new “signal” for detecting disease activity.

2018 ◽  
Vol 147 ◽  
Author(s):  
I. S. Rasmussen ◽  
L. H. Mortensen ◽  
T. G. Krause ◽  
A-M. Nybo Andersen

AbstractIt has been reported that foetal death follows a seasonal pattern. Influenza virus infection has been postulated as one possible contributor to this seasonal variation. This ecological study explored the temporal association between the influenza activity and the frequency of foetal death. Time series analysis was conducted using weekly influenza-like illness consultation proportions from the Danish sentinel surveillance system and weekly proportions of spontaneous abortions and stillbirths from hospital registers from 1994 to 2009. The association was examined in an autoregressive (AR) integrated (I) moving average (MA) model and subsequently analysed with cross-correlation functions. Our findings confirmed the well-known seasonality in influenza, but also seasonality in spontaneous abortion. No clear pattern of seasonality was found for stillbirths, although the analysis exposed dependency between observations. One final AR integrated MA model was identified for the influenza-like illness (ILI) series. We found no statistically significant relationship between weekly influenza-like illness consultation proportions and weekly spontaneous abortion proportions (five lags: P = 0.52; 11 lags: P = 0.91) or weekly stillbirths (five lags: P = 0.93; 11 lags: P = 0.40). Exposure to circulating influenza during pregnancy was not associated with rates of spontaneous abortions or stillbirths. Seasonal variations in spontaneous abortion were confirmed and this phenomenon needs further investigation.


Children ◽  
2017 ◽  
Vol 4 (8) ◽  
pp. 69 ◽  
Author(s):  
Daphne van der Bend ◽  
Tamara Bucher ◽  
Tracy Schumacher ◽  
Kate Collins ◽  
Nienke De Vlieger ◽  
...  

2017 ◽  
Vol 66 (9) ◽  
pp. 1377-1382 ◽  
Author(s):  
Yasi Xiao ◽  
Bianka Paquet-Bolduc ◽  
Christophe Garenc ◽  
Philippe Gervais ◽  
Sylvie Trottier ◽  
...  

2010 ◽  
Vol 139 (3) ◽  
pp. 482-485 ◽  
Author(s):  
K. KAIER ◽  
D. LUFT ◽  
M. DETTENKOFER ◽  
M. KIST ◽  
U. FRANK

SUMMARYA time-series analysis was performed to identify the impact of bed occupancy rates and length of hospital stay on the incidence of Clostridium difficile infections (CDI). Between January 2003 and July 2008, a mean incidence of 0·5 CDI cases/1000 patient days was recorded. Application of a multivariate model (R2=0·50) showed that bed occupancy rates on general wards (P<0·01) and length of stay in intensive care units (ICUs) (P<0·01) influenced the incidence of CDI. Overcrowding on general wards and long periods in ICUs were identified as being positively associated with the incidence of CDI.


Author(s):  
Ye Yao ◽  
Jinhua Pan ◽  
Zhixi Liu ◽  
Xia Meng ◽  
Weidong Wang ◽  
...  

AbstractThe Coronavirus (COVID-19) epidemic, which was first reported in December 2019 in Wuhan, China, has caused 3,314 death as of March 31, 2020 in China. This study aimed to investigate the temporal association between case fatality rate (CFR) of COVID-19 and particulate matter (PM) in Wuhan. We conducted a time series analysis to explore the temporal day-by-day associations. We found COVID-19 held higher case fatality rate with increasing concentrations of PM2.5 and PM10 in temporal scale, which may affect the process of patients developed from mild to severe and finally influence the prognosis of COVID-19 patients.


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