scholarly journals Use of Vaporized Hydrogen Peroxide Decontamination during an Outbreak of Multidrug-ResistantAcinetobacter baumanniiInfection at a Long-Term Acute Care Hospital

2010 ◽  
Vol 31 (12) ◽  
pp. 1236-1241 ◽  
Author(s):  
Amy Ray ◽  
Federico Perez ◽  
Amanda M. Beltramini ◽  
Marta Jakubowycz ◽  
Patricia Dimick ◽  
...  
Keyword(s):  
Susceptibility Testing ◽  
Case Control Study ◽  
Acute Care Hospital ◽  
Case Control ◽  
Control Measures ◽  
Care Hospital ◽  
Infection Control Measures ◽  
Environmental Decontamination ◽  
Control Study

Objectives.To describe vaporized hydrogen peroxide (VHP) as an adjuvant in the control of multidrug-resistant (MDR)Acinetobacter baumanniiinfection in a long-term acute care hospital (LTACH) and to describe the risk factors for acquisition of MDRA. baumanniiinfection in the LTACH population.Design.Outbreak investigation, case-control study, and before-after intervention trial.Setting.A 54-bed LTACH affiliated with a tertiary care center in northeastern Ohio.Methods.Investigation of outbreak with clinical and environmental cultures, antimicrobial susceptibility testing, polymerase chain reaction assay of repetitive chromosomal elements to type strains, and case-control study; and intervention consisting of comprehensive infection control measures and VHP environmental decontamination.Results.Thirteen patients infected or colonized with MDRA. baumanniiwere identified from January 2008 through June 2008. By susceptibility testing, 10 (77%) of the 13 isolates were carbapenem-resistant. MDRA. baumanniiwas found in wound samples, blood, sputum, and urine. Wounds were identified as a risk factor for MDRA. baumanniicolonization. Ventilator-associated pneumonia was the most common clinical syndrome caused by the pathogen, and the associated mortality was 14% (2 of the 13 case patients died). MDRA. baumanniiwas found in 8 of 93 environmental samples, including patient rooms and a wound care cart; environmental and clinical cultures were genetically related. Environmental cultures were negative immediately after VHP decontamination and both 24 hours and 1 week after VHP decontamination. Nosocomial acquisition of the pathogen in the LTACH ceased after VHP Intervention. When patients colonized with MDRA. baumanniireoccupied rooms, environmental contamination recurred.Conclusion.Environmental decontamination using VHP combined with comprehensive infection control measures interrupted nosocomial transmission of MDRA. baumanniiin an LTACH. The application of this novel approach to halt the transmission of MDRA. baumanniiwarrants further investigation.

Spinal Fusion Surgical Site Infections at an Acute Care Hospital: A Case Control Study

2018 ◽  
Vol 46 (6) ◽  
pp. S43
Author(s):  
Tasha M. Turner ◽  
Shannon Kavish ◽  
Jeanne Yegge ◽  
Katherine Yohnke ◽  
Ashleigh J. Goris ◽  
...  
Keyword(s):  
Spinal Fusion ◽  
Acute Care ◽  
Case Control Study ◽  
Acute Care Hospital ◽  
Surgical Site Infections ◽  
Case Control ◽  
Care Hospital ◽  
Control Study

scholarly journals The Emergence ofClostridium difficileInfection among Peripartum Women: A Case-Control Study of aC. difficileOutbreak on an Obstetrical Service

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Jennifer A. Unger ◽  
Estella Whimbey ◽  
Michael G. Gravett ◽  
David A. Eschenbach
Keyword(s):  
Infection Control ◽  
Case Control Study ◽  
Clinical Manifestations ◽  
Antibiotic Use ◽  
Case Control ◽  
Control Measures ◽  
Multiple Infection ◽  
Infection Control Measures ◽  
Significant Independent Risk Factor ◽  
Control Study

Objective. An outbreak of 20 peripartumClostridium difficileinfections (CDI) occurred on the obstetrical service at the University of Washington Medical Center (UWMC) between April 2006 and June 2007. In this report, we characterize the clinical manifestations, describe interventions that appeared to reduce CDI, and determine potential risk factors for peripartum CDI.Methods. An investigation was initiated after the first three peripartum CDI cases. Based on the findings, enhanced infection control measures and a modified antibiotic regimen were implemented. We conducted a case-control study of peripartum cases and unmatched controls.Results. During the outbreak, there was an overall incidence of 7.5 CDI cases per 1000 deliveries. Peripartum CDI infection compared to controls was significantly associated with cesarean delivery (70% versus 34%;P=0.03), antibiotic use (95% versus 56%;P=0.001), chorioamnionitis (35% versus 5%;P=0.001), and the use of the combination of ampicillin, gentamicin, and clindamycin (50% versus 3%;P<0.001). Use of combination antibiotics remained a significant independent risk factor for CDI in the multivariate analysis.Conclusions. The outbreak was reduced after the implementation of multiple infection control measures and modification of antibiotic use. However, sporadic CDI continued for 8 months after these measures slowed the outbreak. Peripartum women appear to be another population susceptible to CDI.

Risk Factors for Nosocomial Bacteremia in a Large Spanish Teaching Hospital: A Case-Control Study

1991 ◽  
Vol 12 (3) ◽  
pp. 150-156 ◽  
Author(s):  
Antoni Trilla ◽  
Josep M. Gatell ◽  
Josep Mensa ◽  
Xavier Latorre ◽  
Manuel Almela ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Strong Support ◽  
Case Control ◽  
Control Measures ◽  
University Hospital ◽  
Stepwise Logistic Regression ◽  
Infection Control Measures ◽  
Nosocomial Bacteremia ◽  
Control Study

AbstractObjective:Identify independent risk factors associated with the development of nosocomial bacteremia.Design:Exploratory, unmatched, case-control study.Setting:A 970-bed Spanish university hospital.Patients:All non-neutropenic adult patients with nosocomial bacteremia admitted during a 12-month period were eligible as cases. All adult non-neutropenic patients without nosocomial bacteremia were eligible as controls.Results:The incidence of bacteremia in the study population was 6.9/1000 admissions/ year. One hundred eighty cases and 180 controls were analyzed. Multivariate analysis (stepwise logistic regression techniques) identified seven risk factors independently associated with nosocomial bacteremia: age above 65 years; prior admission (within six months) to the hospital; underlying diseases that were ultimately or rapidly fatal; indwelling urethral catheter in place for more than three days; intravenous central lines or peripheral venous lines (if in place for more than four days); “high-risk surgery” (i.e., lower abdominal, cardiac or thoracic); and admission to an intensive care unit.Conclusions:Although five variables are not modifiable, the remaining two relate to the use and duration of devices. Our data give strong support for the value of testing strict guidelines for limiting vascular catheters and evaluating the need for prolonged urethral catheterization. If effective infection control measures are identified, we could target hospital-wide surveillance to patients whose risk factors are amenable to intervention.

scholarly journals Similar Prevalence of Long-Term Post-COVID Symptoms in Patients with Asthma: A Case-Control Study

2021 ◽  
Author(s):  
César Fernández-de-las-Peñas ◽  
Juan Torres-Macho ◽  
Maria Velasco-Arribas ◽  
Jose A. Arias-Navalón ◽  
Carlos Guijarro ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Control Study
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