scholarly journals Impact of Single Nucleotide Polymorphisms and of Clinical Risk Factors on New‐Onset Diabetes Mellitus in HIV‐Infected Individuals

2010 ◽  
Vol 51 (9) ◽  
pp. 1090-1098 ◽  
Author(s):  
Margalida Rotger ◽  
Thomas Gsponer ◽  
Raquel Martinez ◽  
Patrick Taffé ◽  
Luigia Elzi ◽  
...  
2021 ◽  
Vol Volume 14 ◽  
pp. 4783-4792
Author(s):  
Jushan Sun ◽  
Yibiao He ◽  
Lei Bai ◽  
Zhipeng Wang ◽  
Zhu Cao ◽  
...  

2020 ◽  
Vol 8 (2) ◽  
pp. e001778
Author(s):  
Menghua Dai ◽  
Cheng Xing ◽  
Ning Shi ◽  
Shunda Wang ◽  
Guangdong Wu ◽  
...  

IntroductionSeveral previous studies have reported the incidence of new-onset diabetes mellitus (NODM) after pancreatectomy. Nevertheless, the results were inconsistent. The true rate of NODM after distal pancreatectomy (DP) is still unknown.Research design and methodsThe aim of this study was to investigate the incidence of and the risk factors for NODM after DP. This study enrolled patients who underwent DP between January 2004 and February 2016 at Peking Union Medical College Hospital. Patients with preoperative diabetes mellitus or diagnosed with pancreatic cancer were excluded. The primary outcome was NODM.ResultsA total of 485 patients were enrolled. The median (IQR) of follow-up duration was 30.95 (9.26–180.30) months. The accumulative incidence of NODM was 8.9% at postoperative 6 months, 14.0% at postoperative year one, 22.3% at year three, 27.1% at year five, and 35.5% at year ten. Multivariate analysis showed that the risk of postoperative NODM was positively correlated with age (HR 1.029 (1.013–1.045), p<0.001), preoperative body mass index (BMI) (HR 1.042 (1.003–1.083), p=0.001), operative blood loss (HR 1.0003 (1.0002–1.0010), p<0.001), and length of resected pancreas (HR 1.079 (1.013–1.148), p=0.017). Moreover, concomitant splenectomy (HR 2.001 (1.202–3.331), p=0.008) was associated with significantly higher risk of postoperative NODM.ConclusionNODM incidence increased with postoperative time progression. Age, BMI, surgical blood loss, length of resected pancreas and splenectomy were independent risk factors for NODM after DP.Trial registration numberNCT03030209.


2009 ◽  
Vol 169 (8) ◽  
pp. 798 ◽  
Author(s):  
Dariush Mozaffarian ◽  
Aruna Kamineni ◽  
Mercedes Carnethon ◽  
Luc Djoussé ◽  
Kenneth J. Mukamal ◽  
...  

2010 ◽  
Vol 90 ◽  
pp. 695
Author(s):  
S. GULERIA ◽  
G. Bora ◽  
N. Tandon ◽  
N. Gupta ◽  
S. Agarwal ◽  
...  

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