scholarly journals Changes in Blood B Cell Phenotypes and Epstein‐Barr Virus Load in Chronically Human Immunodeficiency Virus–Infected Patients before and after Antiretroviral Therapy

2010 ◽  
Vol 202 (9) ◽  
pp. 1424-1434 ◽  
Author(s):  
Yolande Richard ◽  
Corinne Amiel ◽  
Vincent Jeantils ◽  
Denis Mestivier ◽  
Alain Portier ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
B Cell ◽  
Epstein Barr Virus ◽  
Virus Load ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Before And After ◽  
Epstein Barr ◽  
Cell Phenotypes

Low-Grade Monoclonal Epstein-Barr Virus–Associated Lymphoproliferative Disorder of the Brain Presenting as Human Immunodeficiency Virus–Associated Encephalopathy in a Child With Acquired Immunodeficiency Syndrome

1999 ◽  
Vol 123 (1) ◽  
pp. 83-87
Author(s):  
D. W. Kingma ◽  
B. U. Mueller ◽  
K. Frekko ◽  
L. R. Sorbara ◽  
L. V. Wood ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Human Immunodeficiency Virus ◽  
B Cell ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Epstein Barr ◽  
Immunodeficiency Syndrome

Abstract The association of the Epstein-Barr virus with human immunodeficiency virus–associated primary central nervous system lymphomas is well known. We describe a pediatric patient infected with human immunodeficiency virus who developed a lesion in the central nervous system that appeared to be histologically reactive and that proved to be an Epstein-Barr virus–associated monoclonal B-cell lymphoproliferative disorder by molecular analysis. An 8-year-old girl was diagnosed with vertically transmitted human immunodeficiency virus infection at age 5, for which she was treated empirically with a combination of zidovudine and didanosine. At the age of 7 years, during evaluation for entry into an antiretroviral protocol, a single hypodense frontal lobe lesion was identified by computed tomography. After unsuccessful treatment for presumed toxoplasmosis and progressive neurologic deterioration, a stereotactic brain biopsy was performed. Although the biopsy contained a polymorphic lymphoid infiltrate that appeared to be cytologically reactive, polymerase chain reaction and in situ hybridization studies revealed a monoclonal Epstein-Barr virus–associated B-cell lymphoproliferative disorder, which was reminiscent of polymorphic B-cell hyperplasia observed in the setting of immunosuppression following organ transplantation. Postoperative therapy included steroids and antiretroviral therapy. The lesion decreased slightly in size, and the child's neurologic status was relatively unremarkable for 5 months. Subsequently, she developed cytomegalovirus retinitis, progressive encephalopathy, and died with pancytopenia. This case represents a newly described manifestation of Epstein-Barr virus–associated lymphoproliferative disorder, a diagnosis that should be considered in patients with neurologic symptoms and immunodeficiency. In addition, this case exhibited histologic features reminiscent of posttransplant lymphoproliferative disease, a histologic pattern that to our knowledge has not previously been reported in the setting of acquired immunodeficiency syndrome.

Impact of Epstein-Barr virus load, virus genotype, and frequency of the 30 bp deletion in the viral BNLF-1 gene in patients harboring the human immunodeficiency virus

2013 ◽  
Vol 85 (12) ◽  
pp. 2110-2118 ◽  
Author(s):  
Leila Bertoni Giron ◽  
Suzane Ramos da Silva ◽  
Alexandre Naime Barbosa ◽  
Ricardo Augusto Monteiro de Barros Almeida ◽  
Lenice do Rosário de Souza ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Epstein Barr Virus ◽  
Virus Genotype ◽  
Virus Load ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr

scholarly journals Plasma Epstein-Barr Virus Load as an Early Biomarker and Prognostic Factor of Human Immunodeficiency Virus–related Lymphomas

2018 ◽  
Vol 68 (5) ◽  
pp. 834-843 ◽  
Author(s):  
Josep Muncunill ◽  
Maria-Joao Baptista ◽  
Águeda Hernandez-Rodríguez ◽  
Judith Dalmau ◽  
Olga Garcia ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Prognostic Factor ◽  
Epstein Barr Virus ◽  
Virus Load ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Early Biomarker ◽  
Epstein Barr

scholarly journals Epstein-Barr Virus Load in Children Infected With Human Immunodeficiency Virus Type 1 in Uganda

2014 ◽  
Vol 210 (3) ◽  
pp. 392-399 ◽  
Author(s):  
M. R. Petrara ◽  
M. Penazzato ◽  
W. Massavon ◽  
S. Nabachwa ◽  
M. Nannyonga ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Epstein Barr Virus ◽  
Virus Load ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr

Epstein-Barr Virus load and immune activation in Human Immunodeficiency Virus type 1-infected patients

2012 ◽  
Vol 53 (3) ◽  
pp. 195-200 ◽  
Author(s):  
Maria Raffaella Petrara ◽  
Anna Maria Cattelan ◽  
Marisa Zanchetta ◽  
Lolita Sasset ◽  
Riccardo Freguja ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immune Activation ◽  
Epstein Barr Virus ◽  
Virus Load ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr
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