scholarly journals Human Immunodeficiency Virus Treatment–Induced Adipose Tissue Pathology and Lipoatrophy: Prevalence and Metabolic Consequences

2010 ◽  
Vol 51 (5) ◽  
pp. 591-599 ◽  
Author(s):  
Emma Hammond ◽  
Elizabeth McKinnon ◽  
David Nolan
Keyword(s):  
Human Immunodeficiency Virus ◽  
Adipose Tissue ◽  
Human Immunodeficiency Virus Treatment ◽  
Immunodeficiency Virus

Relation of Subepicardial Adipose Tissue to Carotid Intima-Media Thickness in Patients With Human Immunodeficiency Virus

2007 ◽  
Vol 99 (10) ◽  
pp. 1470-1472 ◽  
Author(s):  
Gianluca Iacobellis ◽  
Adriano M. Pellicelli ◽  
Arya M. Sharma ◽  
Benvenuto Grisorio ◽  
Giorgio Barbarini ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Adipose Tissue ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Immunodeficiency Virus

scholarly journals Effects of a brief video intervention on treatment initiation and adherence among patients attending human immunodeficiency virus treatment clinics

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0204599 ◽  
Author(s):  
Mary Spink Neumann ◽  
Aaron Plant ◽  
Andrew D. Margolis ◽  
Craig B. Borkowf ◽  
C. Kevin Malotte ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Treatment Initiation ◽  
Human Immunodeficiency Virus Treatment ◽  
Video Intervention ◽  
Immunodeficiency Virus

DI-076 Clinical experience with darunavir plus cobicistat combination in human immunodeficiency virus treatment

2017 ◽  
Author(s):  
A Tomás Luiz ◽  
L Menéndez Naranjo ◽  
M Almanchel Rivadeneyra ◽  
A Mancebo González ◽  
JJ Fernández Ávila
Keyword(s):  
Human Immunodeficiency Virus ◽  
Clinical Experience ◽  
Human Immunodeficiency Virus Treatment ◽  
Immunodeficiency Virus

scholarly journals Optimization of Human Immunodeficiency Virus Treatment During Incarceration

2014 ◽  
Vol 174 (5) ◽  
pp. 721 ◽  
Author(s):  
Jaimie P. Meyer ◽  
Javier Cepeda ◽  
Johnny Wu ◽  
Robert L. Trestman ◽  
Frederick L. Altice ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Treatment ◽  
Immunodeficiency Virus

scholarly journals Focus on Increasing Treatment Self-Efficacy to Improve Human Immunodeficiency Virus Treatment Adherence

2012 ◽  
Vol 44 (4) ◽  
pp. 403-410 ◽  
Author(s):  
Kathleen Nokes ◽  
Mallory O. Johnson ◽  
Allison Webel ◽  
Carol Dawson Rose ◽  
J. Craig Phillips ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Treatment Adherence ◽  
Self Efficacy ◽  
Human Immunodeficiency Virus Treatment ◽  
Immunodeficiency Virus

scholarly journals Antiretroviral Therapy Initiation Is Associated With Decreased Visceral and Subcutaneous Adipose Tissue Density in People Living With Human Immunodeficiency Virus

2020 ◽  
Author(s):  
Paula Debroy ◽  
Jordan E Lake ◽  
Carlee Moser ◽  
Maxine Olefsky ◽  
Kristine M Erlandson ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Human Immunodeficiency Virus ◽  
Adipose Tissue ◽  
Antiretroviral Therapy ◽  
Hdl Cholesterol ◽  
Cd4 T Cell ◽  
Art Initiation ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Cd4 T Cell Count

Abstract Background Adipose tissue (AT) alterations are common in people living with human immunodeficiency virus (PLWH). Decreases in AT density suggest disrupted adipocyte function/hypertrophy. We assessed changes in AT density after antiretroviral therapy (ART) initiation and associations with immunometabolic parameters. Methods In a prospective randomized clinical trial of ART initiation, L4–L5 abdominal CT scans measured subcutaneous AT (SAT) and visceral AT (VAT) area and density in treatment-naive PLWH randomized to tenofovir-emtricitabine plus ritonavir-boosted atazanavir, ritonavir-boosted darunavir, or raltegravir. Linear regression models compared week 0 and week 96 levels, and 96-week changes, in SAT and VAT density (in Hounsfield units [HU]). Spearman correlations assessed relationships between AT density and immunometabolic parameters. Results Of the 228 participants, 89% were male and 44% were white non-Hispanic. Median age was 36 years, baseline HIV-1 RNA was 4.6 log10 copies/mL, and CD4+ T-cell count was 344 cells/μL. Over 96 weeks, SAT and VAT HU decreased significantly in all arms. Less dense week 96 SAT and VAT density correlated with higher high-density lipoprotein (HDL) cholesterol and adiponectin (r = 0.19–0.30) levels and lower interleukin 6, non-HDL cholesterol, triglyceride, leptin, and homeostatic model assessment of insulin resistance (r = −0.23 to −0.68) levels at week 96 after adjusting for baseline CD4+ T-cell count, HIV-1 RNA, and baseline AT area. Conclusions Following virologic suppression, lower SAT and VAT density was associated with greater plasma measures of systemic inflammation, lipid disturbances, and insulin resistance independent of AT area, suggesting that changes in AT density with ART may lead to adverse health outcomes independent of AT quantity. Clinical Trials Registration NCT00851799.

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