Antiviral Treatment of Patients with Oseltamivir‐Resistant and Oseltamivir‐Susceptible Seasonal Influenza A (H1N1) Infection during the 2007–2008 Influenza Season in the United States

2010 ◽  
Vol 50 (4) ◽  
pp. 621-622 ◽  
Author(s):  
Nila J. Dharan ◽  
Larisa V. Gubareva ◽  
Alexander I. Klimov ◽  
Anthony E. Fiore ◽  
Joseph S. Bresee ◽  
...  
Keyword(s):  
United States ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Influenza Season ◽  
Antiviral Treatment ◽  
The United States ◽  
H1n1 Infection ◽  
Influenza A H1n1

scholarly journals Lessons from the Past: Comparison of the Disease Burden of the Influenza A (H1N1) Pandemic 2009-10 and Seasonal Influenza 2010-2019 in the United States

2021 ◽  
Author(s):  
James A Koziol
Keyword(s):  
United States ◽  
Influenza A ◽  
Disease Burden ◽  
Seasonal Influenza ◽  
The United States ◽  
H1n1 Pandemic ◽  
Elderly Adults ◽  
The Past ◽  
Medical Visits ◽  
Influenza A H1n1

Abstract Background Annual influenza outbreaks constitute a major public health concern, both in the United States and worldwide. Comparisons of the health burdens of outbreaks might lead to the identification of specific at-risk populations, for whom public health resources should be marshaled appropriately and equitably. Methods We examined the disease burden of the 2009-10 influenza A (H1N1) pandemic relating to illnesses, medical visits, hospitalizations, and mortality, compared to influenza seasons 2010 to 2019, in the United States, as compiled by the Centers for Disease Control. Results With regard to seasonal influenza, rates of illnesses and medical visits were highest in infants aged 0–4 years, followed by adults aged 50–64 years. Rates of hospitalizations and deaths evinced a starkly different pattern, both dominated by elderly adults aged 65 and over. Youths aged 0 to 17 years were especially adversely affected by the H1N1 pandemic relative to hospitalizations and mortality compared to seasonal influenza; but curiously the opposite pattern was observed in elderly adults (aged 65 and older). Conclusions The disease burden of the 2009-10 influenza A pandemic was strikingly unlike that observed in the subsequent influenza seasons 2010 to 2019, in the United States: the past did not predict the future.

scholarly journals Effects of Influenza Vaccination in the United States During the 2017–2018 Influenza Season

2019 ◽  
Vol 69 (11) ◽  
pp. 1845-1853 ◽  
Author(s):  
Melissa A Rolfes ◽  
Brendan Flannery ◽  
Jessie R Chung ◽  
Alissa O’Halloran ◽  
Shikha Garg ◽  
...  
Keyword(s):  
United States ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Influenza A ◽  
Influenza Season ◽  
Influenza Virus Infection ◽  
The United States ◽  
Influenza B ◽  
Medical Visits ◽  
Influenza A H1n1

Abstract Background The severity of the 2017–2018 influenza season in the United States was high, with influenza A(H3N2) viruses predominating. Here, we report influenza vaccine effectiveness (VE) and estimate the number of vaccine-prevented influenza-associated illnesses, medical visits, hospitalizations, and deaths for the 2017–2018 influenza season. Methods We used national age-specific estimates of 2017–2018 influenza vaccine coverage and disease burden. We estimated VE against medically attended reverse-transcription polymerase chain reaction–confirmed influenza virus infection in the ambulatory setting using a test-negative design. We used a compartmental model to estimate numbers of influenza-associated outcomes prevented by vaccination. Results The VE against outpatient, medically attended, laboratory-confirmed influenza was 38% (95% confidence interval [CI], 31%–43%), including 22% (95% CI, 12%–31%) against influenza A(H3N2), 62% (95% CI, 50%–71%) against influenza A(H1N1)pdm09, and 50% (95% CI, 41%–57%) against influenza B. We estimated that influenza vaccination prevented 7.1 million (95% CrI, 5.4 million–9.3 million) illnesses, 3.7 million (95% CrI, 2.8 million–4.9 million) medical visits, 109 000 (95% CrI, 39 000–231 000) hospitalizations, and 8000 (95% credible interval [CrI], 1100–21 000) deaths. Vaccination prevented 10% of expected hospitalizations overall and 41% among young children (6 months–4 years). Conclusions Despite 38% VE, influenza vaccination reduced a substantial burden of influenza-associated illness, medical visits, hospitalizations, and deaths in the United States during the 2017–2018 season. Our results demonstrate the benefit of current influenza vaccination and the need for improved vaccines.

scholarly journals Planning for the Control of Pandemic Influenza A (H1N1) in Los Angeles County and the United States

2011 ◽  
Vol 173 (10) ◽  
pp. 1121-1130 ◽  
Author(s):  
D. L. Chao ◽  
L. Matrajt ◽  
N. E. Basta ◽  
J. D. Sugimoto ◽  
B. Dean ◽  
...  
Keyword(s):  
United States ◽  
Los Angeles ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Los Angeles County ◽  
The United States ◽  
Influenza A H1n1

scholarly journals Household Transmission of 2009 Pandemic Influenza A (H1N1) Virus in the United States

2009 ◽  
Vol 361 (27) ◽  
pp. 2619-2627 ◽  
Author(s):  
Simon Cauchemez ◽  
Christl A. Donnelly ◽  
Carrie Reed ◽  
Azra C. Ghani ◽  
Christophe Fraser ◽  
...  
Keyword(s):  
United States ◽  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
The United States ◽  
Household Transmission ◽  
Influenza A H1n1

scholarly journals Epidemiology of 2009 Pandemic Influenza A (H1N1) Deaths in the United States, April-July 2009

2010 ◽  
Vol 52 (Supplement 1) ◽  
pp. S60-S68 ◽  
Author(s):  
A. L. Fowlkes ◽  
P. Arguin ◽  
M. S. Biggerstaff ◽  
J. Gindler ◽  
D. Blau ◽  
...  
Keyword(s):  
United States ◽  
Pandemic Influenza ◽  
Influenza A ◽  
The United States ◽  
Influenza A H1n1

scholarly journals Hospitalized Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection in the United States—September–October 2009

2011 ◽  
Vol 52 (suppl_1) ◽  
pp. S50-S59 ◽  
Author(s):  
Jacek Skarbinski ◽  
Seema Jain ◽  
Anna Bramley ◽  
Esther J. Lee ◽  
Jean Huang ◽  
...  
Keyword(s):  
United States ◽  
Virus Infection ◽  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
The United States ◽  
Hospitalized Patients ◽  
Influenza A H1n1 ◽  
H1n1 Virus Infection
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